DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and CHD1L

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_004275.4	Gene:	CHD1L / 9557	HGNCID:	1916	Length:	897	Species:	Homo sapiens

Alignment Length:	853	Identity:	290/853 - (33%)
Similarity:	437/853 - (51%)	Gaps:	129/853 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 MRDYQIRGLNWMISLY--ENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQ 190
            :|.||:.|:||:...:  :||.  ||.||||||||.|||:|..||....|..||.:::.|.|.|.
Human    46 LRSYQLEGVNWLAQRFHCQNGC--ILGDEMGLGKTCQTIALFIYLAGRLNDEGPFLILCPLSVLS 108

  Fly   191 NWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRYLVI 255
            ||..|.:::.|.|..|...||::.|....:|:.....:.|.:|:||:|:::.|..|.|.|..||:
Human   109 NWKEEMQRFAPGLSCVTYAGDKEERACLQQDLKQESRFHVLLTTYEICLKDASFLKSFPWSVLVV 173

  Fly   256 DEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSE--DFDEWFN 318
            |||||:||:.|.|.:.|.||.....||:||||:||:|.||::||:|:.||:|:..|  ||.:.:.
Human   174 DEAHRLKNQSSLLHKTLSEFSVVFSLLLTGTPIQNSLQELYSLLSFVEPDLFSKEEVGDFIQRYQ 238

  Fly   319 TNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVV 383
            ......:.|  :.||.:|:||||||:||||...|..|.|:.|:.|:|.:|:.:|..:|:||:|..
Human   239 DIEKESESA--SELHKLLQPFLLRRVKAEVATELPKKTEVVIYHGMSALQKKYYKAILMKDLDAF 301

  Fly   384 NGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGS 448
            ... ..:|::|||||.|||||.:|||||||.|| .|:....||...|||:.:|||||..|...|.
Human   302 ENE-TAKKVKLQNILSQLRKCVDHPYLFDGVEP-EPFEVGDHLTEASGKLHLLDKLLAFLYSGGH 364

  Fly   449 RVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLG 513
            |||:|||||:|||||:||..:|.|:|.|:||....|:|:..|:.|.  ....|:|:|||||||:|
Human   365 RVLLFSQMTQMLDILQDYMDYRGYSYERVDGSVRGEERHLAIKNFG--QQPIFVFLLSTRAGGVG 427

  Fly   514 INLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKM 578
            :||..||.||..|||:|||.||||..|||||||.|.|:|.|||...||||.:..:|..||:|..|
Human   428 MNLTAADTVIFVDSDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNM 492

  Fly   579 VIQGGRL-VDNRSNQLNKD-EMLNIIRFGANQVFSSKETDITDEDIDVILERGEAKTAEQKAALD 641
            :|:||.. :..:....:.| ::..|::||.:::.:|:.:.:.:.|::.||  ||.|..:..:...
Human   493 IIEGGHFTLGAQKPAADADLQLSEILKFGLDKLLASEGSTMDEIDLESIL--GETKDGQWVSDAL 555

  Fly   642 SLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPKRERKANYAVDAYFREAL 706
            ...|...|      :.|.|.:.:|.|||:|:.:           ||.|.:||:       |.:.:
Human   556 PAAEGGSR------DQEEGKNHMYLFEGKDYSK-----------EPSKEDRKS-------FEQLV 596

  Fly   707 RVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKVPKNTELGSDATKVQR-- 769
            .:.:                       .|.|...||....|......:|...| ||  ||.:|
Human   597 NLQK-----------------------TLLEKASQEGRSLRNKGSVLIPGLVE-GS--TKRKRVL 635

  Fly   770 ------EEQRKIDEA----EPLTEEEIQEKENLLSQGFTA-WTKRDFNQFIKANEKYGRDDIDNI 823
                  :.|:|..||    ..|.||:.::||....:...| |...::..|...:|:...:|::|
Human   636 SPEELEDRQKKRQEAAAKRRRLIEEKKRQKEEAEHKKKMAWWESNNYQSFCLPSEESEPEDLEN- 699

  Fly   824 AKDVEGKTPEEVIEYNAVFWERCTELQDIERIMGQIER--------------------GEGKIQR 868
                 |:.....::|      :..:...::.:.|.:..                    |.|.:..
Human   700 -----GEESSAELDY------QDPDATSLKYVSGDVTHPQAGAEDALIVHCVDDSGHWGRGGLFT 753

  Fly   869 RLSIKKALDQKMSRYRAPFHQLRL----------QYGNNKGKNYTEIEDRFLVCMLHKLGFDKEN 923
            .|..:.|..:|:.........|.|          :...|||::...     |:...|:   |:.|
Human   754 ALEKRSAEPRKIYELAGKMKDLSLGGVLLFPVDDKESRNKGQDLLA-----LIVAQHR---DRSN 810

  Fly   924 VYEELRAA 931
            |...::.|
Human   811 VLSGIKMA 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603
		SNF2_N	131..411	CDD:278600	122/283 (43%)
		DEXDc	148..287	CDD:238005	59/138 (43%)
		HELICc	422..553	CDD:238034	72/130 (55%)
		HAND	697..796	CDD:286232	22/110 (20%)
		SANT	797..838	CDD:197842	7/41 (17%)
		SANT	799..838	CDD:238096	7/39 (18%)
		SLIDE	853..965	CDD:286233	17/109 (16%)
CHD1L	NP_004275.4	SNF2_N	46..699	CDD:331286	270/712 (38%)
		DEAH box	174..177		2/2 (100%)
		Required for helicase activity. /evidence=ECO:0000269\|PubMed:29220653	615..673		16/60 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	628..654		8/27 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..711		5/35 (14%)
		Macro_Poa1p_like_SNF2	716..866	CDD:239447	17/111 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0385
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820