Protein Alignment Iswi and Smarca1

DIOPT Version :10

• Sequence 1: NP_523719.1
• Gene: Iswi / 36390
• FlyBaseID: FBgn0011604
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_001277637.1
• Gene: Smarca1 / 93761
• MGIID: 1935127
• Length: 1062
• Species: Mus musculus
• Alignment Length: 1053
• Identity: 737/1053 - (69%)
• Similarity: 863/1053 - (81%)
• Gaps: 56/1053 - (5%)

  Fly     3 KTDTAAVEATE--------ENSNETTSD-----AATSSSGEKE--AEFDNK-----IEADRSRRF 47
            |.:.||..|||        |...:.||.     ||.:|..|||  .|::.|     ::|||::||
Mouse    35 KEEGAAAAATEGTTATEKGEKKEKITSPFQLKLAAKASKSEKEMDPEYEEKMVNMPLKADRAKRF 99

  Fly    48 DFLLKQTEIFTHFMTNSA-KSPTKP----KGRPKKIKDKDKEK--DVADHRHRKTEQEEDEELLA 105
            :|||||||:|.||:..|| ||||.|    ..|| ::|..||:.  .|.|:|||:||||||||||:
Mouse   100 EFLLKQTELFAHFIQPSAQKSPTSPLNMKLARP-RVKKDDKQSLISVGDYRHRRTEQEEDEELLS 163

  Fly   106 EDSATKEI-FRFDASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGY 169
            |...|..: .||:.||:|:|.|.:||||||||||:|||||||:|||||||||||||||||:||||
Mouse   164 ESRKTSNVCVRFEVSPSYVKGGPLRDYQIRGLNWLISLYENGVNGILADEMGLGKTLQTIALLGY 228

  Fly   170 LKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTS 234
            |||::|..|||:|:||||||.||:||||:|.||||.:|.:||:|.|..||||.:|||||||||||
Mouse   229 LKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGDKDVRAAFIRDEMMPGEWDVCVTS 293

  Fly   235 YEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALL 299
            |||.|:||||||||:||||||||||||||||||||||:||||:.||||:||||||||||||||||
Mouse   294 YEMVIKEKSVFKKFHWRYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALL 358

  Fly   300 NFLLPDVFNSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGL 364
            ||||||||||::|||.||:|..||||..|:.|||||||||||||:|.:|||.|.||||:||::||
Mouse   359 NFLLPDVFNSADDFDSWFDTKNCLGDQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGL 423

  Fly   365 SKMQRDWYTKVLLKDIDVVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYN 429
            |||||:||||:|:|||||:|.:||::||||.|||||||||.||||||||||||||||||.|:|.|
Mouse   424 SKMQREWYTKILMKDIDVLNSSGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVGN 488

  Fly   430 SGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFN 494
            ||||..|||||.:::||||||||||||||:||||||||.||.|.|.|||||||||:|...|..||
Mouse   489 SGKMVALDKLLARIKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYSRLDGQTPHEEREEAIDAFN 553

  Fly   495 MDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITES 559
            ..||:||:|||||||||||||||:|||||:||||||||:|||||||||||||||.||||||||::
Mouse   554 APNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDN 618

  Fly   560 TVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDV 624
            ||||:||||||:|||||.:|||.|||:|.:||:|.|:|||.:||.||..||:.||:::|||||..
Mouse   619 TVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFACKESELTDEDIVT 683

  Fly   625 ILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPK 689
            ||||||.||||....:..:||||||.|.||..     .|:|:|||||:||||||..: .||||||
Mouse   684 ILERGEKKTAEMNERMQKMGESSLRNFRMDLE-----QSLYKFEGEDYREKQKLGTV-EWIEPPK 742

  Fly   690 RERKANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKV 754
            |||||||||||||||||||||||.||||||||||.|||||||||||||||::||.|:|||:||||
Mouse   743 RERKANYAVDAYFREALRVSEPKIPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKV 807

  Fly   755 PKNTELGSDATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDD 819
            |:|.|:.:.|. .|||||:|||.|||||.:|.:||:.||:||||.||||||||||||||||||||
Mouse   808 PRNPEIPNPAI-AQREEQKKIDGAEPLTPQETEEKDKLLTQGFTNWTKRDFNQFIKANEKYGRDD 871

  Fly   820 IDNIAKDVEGKTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYR 884
            |||||::||||:||||:||:|||||||.||||||:||.||||||.:||||:|||||||.|::||:
Mouse   872 IDNIAREVEGKSPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDAKIARYK 936

  Fly   885 APFHQLRLQYGNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTA 949
            |||||||:|||.:|||||||.|||||:|||||:|||:||||||||..:|.:||||||||||||||
Mouse   937 APFHQLRIQYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEELRQCVRNAPQFRFDWFIKSRTA 1001

  Fly   950 LELQRRCNTLITLIERENIELEEKERAEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQKRKSE 1014
            :|.||||||||:|||:||:|:||:|||||||:|.|             ||       .|||||:|
Mouse  1002 MEFQRRCNTLISLIEKENMEIEERERAEKKKRATK-------------TP-------MSQKRKAE 1046

  Fly  1015 VVATSSNSKKKKK 1027
            ....||..|..||
Mouse  1047 SATESSGRKDVKK 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	PLN03142	46..967	CDD:215601	690/928 (74%)
Smarca1	NP_001277637.1	PLN03142	2..1061	CDD:215601	737/1053 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..61		7/25 (28%)
		DEAH box	315..318		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	819..840		14/20 (70%)