DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and BTAF1

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_003963.1	Gene:	BTAF1 / 9044	HGNCID:	17307	Length:	1849	Species:	Homo sapiens

Alignment Length:	701	Identity:	211/701 - (30%)
Similarity:	315/701 - (44%)	Gaps:	151/701 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 TEIFT---HFMTNSAKSPTKPKGRPKKIKDKDKEKDVADHRHRKTEQEEDEELLAEDSATKEIFR 115
            |:.|.   ..|...|..|..|....:.|:.|.||:...            |:||  |....|.::
Human  1207 TQCFATLIRLMPLEAGIPDPPNMSAELIQLKAKERHFL------------EQLL--DGKKLENYK 1257

  Fly   116 FDASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPH 180
            .   |..| :.|:|.||..|:||:..|.:..::|||.|:||||||||:|.:|         ||.|
Human  1258 I---PVPI-NAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICIL---------AGDH 1309

  Fly   181 --------------------IVIVPKSTLQNWVNEFKKWCPS--LRAVCLIGDQDTRNTFIRDVL 223
                                :|:.|.:...:||:|..|:|..  |..:...|....|   ||...
Human  1310 CHRAQEYARSKLAECMPLPSLVVCPPTLTGHWVDEVGKFCSREYLNPLHYTGPPTER---IRLQH 1371

  Fly   224 MPGEWDVCVTSYEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPL 288
            .....::.|.||::...:...|:...:.|.::||.|.|||.|:|||:.:::.....|::::|||:
Human  1372 QVKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPI 1436

  Fly   289 QNNLHELWALLNFLLPDVFNSSEDFDEWFNTNTCLGDDA------------LITRLHAVLKPFLL 341
            |||:.|||:|.:||:|....:...|...:........||            .:..||..:.||||
Human  1437 QNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQVLPFLL 1501

  Fly   342 RRLKAEVEKRLKPKKEMKIFVGLSKMQRDWY---TKVLLK-DID-VVNGA---GKVEKMRLQ--- 395
            ||:|.:|.:.|.||.....:..||.:|...|   .|...| |:| .|:.|   .:.||.:|:
Human  1502 RRMKEDVLQDLPPKIIQDYYCTLSPLQVQLYEDFAKSRAKCDVDETVSSATLSEETEKPKLKATG 1566

  Fly   396 ---NILMQLRKCTNHPYLF---------DGAEPGPPYTTDTHLVYNSGKMAILDKLL-------P 441
               ..|..|||..|||.|.         ..||......:..|.:.::.|::.|.:||       .
Human  1567 HVFQALQYLRKLCNHPALVLTPQHPEFKTTAEKLAVQNSSLHDIQHAPKLSALKQLLLDCGLGNG 1631

  Fly   442 KLQEQGS-------RVLIFSQMTRMLDILEDYC---HWRNYNYCRLDGQTPHEDRNRQIQEFNMD 496
            ...|.|:       |:|||.|:..||||:|...   |..:..|.||||..|...|:..:..||.|
Human  1632 STSESGTESVVAQHRILIFCQLKSMLDIVEHDLLKPHLPSVTYLRLDGSIPPGQRHSIVSRFNND 1696

  Fly   497 NSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTV 561
            .|...| :|:|..||||:||..||.|:..:.||||..||||||||||||||:.|.|:||||..|:
Human  1697 PSIDVL-LLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTL 1760

  Fly   562 EEKIVERAEVKLRLDKMVIQGGRLVDNRSNQ-LNKDEMLNIIRFGANQVFSSKETDITDEDIDVI 625
            ||||:...:.|:.:...||.    .:|.|.| :..|::|::...              |:|
Human  1761 EEKIMGLQKFKMNIANTVIS----QENSSLQSMGTDQLLDLFTL--------------DKD---- 1803

  Fly   626 LERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQ 676
               |:|:.|:                 ..|:|:|...|:.:...:.|.::|
Human  1804 ---GKAEKAD-----------------TSTSGKASMKSILENLSDLWDQEQ 1834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	4/15 (27%)
		SNF2_N	131..411	CDD:278600	100/327 (31%)
		DEXDc	148..287	CDD:238005	46/160 (29%)
		HELICc	422..553	CDD:238034	60/147 (41%)
		HAND	697..796	CDD:286232
		SANT	797..838	CDD:197842
		SANT	799..838	CDD:238096
		SLIDE	853..965	CDD:286233
BTAF1	NP_003963.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..97
		Nuclear localization signal. /evidence=ECO:0000255	191..207
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..247
		HEAT repeat	286..314	CDD:293787
		HEAT repeat	352..377	CDD:293787
		HEAT 1	385..422
		HEAT repeat	390..419	CDD:293787
		HEAT 2	426..463
		HEAT repeat	430..460	CDD:293787
		HEAT repeat	475..495	CDD:293787
		HEAT repeat	506..541	CDD:293787
		HEAT 3	513..550
		HEAT 4	554..596
		DUF3535	594..1051	CDD:314863
		HEAT 5	818..855
		HEAT 6	872..910
		HEAT repeat	1008..1033	CDD:293787
		HEAT repeat	1053..1091	CDD:293787
		HEAT 7	1102..1139
		HEAT repeat	1106..1136	CDD:293787
		HEAT repeat	1144..1171	CDD:293787
		HEAT 8	1182..1219		3/11 (27%)
		HEAT repeat	1184..1213	CDD:293787	2/5 (40%)
		HepA	<1236..1801	CDD:223627	193/613 (31%)
		DEGH box	1404..1407		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920