DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and STH1

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_012140.1	Gene:	STH1 / 854680	SGDID:	S000001388	Length:	1359	Species:	Saccharomyces cerevisiae

Alignment Length:	1058	Identity:	345/1058 - (32%)
Similarity:	514/1058 - (48%)	Gaps:	204/1058 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKTDTAAVEATEENSNETTSDAATSSSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHFMTNSA 65
            |.|.:...:|.|.:..      .|...|.::|| :...::..:..|...||:||..|    .:|.
Yeast   362 MEKDEQKRIERTAKQR------LAALKSNDEEA-YLKLLDQTKDTRITQLLRQTNSF----LDSL 415

  Fly    66 KSPTKPKGRPKKIKDKDKEKDVADHRHRKTEQEEDEELLAEDSATKEIFRFDASPAYIKSGEMRD 130
            ....:.:....||...::.:.:.|....||:..|....:.|        :.|..|:.:..|.:::
Yeast   416 SEAVRAQQNEAKILHGEEVQPITDEEREKTDYYEVAHRIKE--------KIDKQPSILVGGTLKE 472

  Fly   131 YQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNE 195
            ||:|||.||:|||.|.:|||||||||||||:|:|||:.||...|...||.:||||.||:.||..|
Yeast   473 YQLRGLEWMVSLYNNHLNGILADEMGLGKTIQSISLITYLYEVKKDIGPFLVIVPLSTITNWTLE 537

  Fly   196 FKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRYLVIDEAHR 260
            |:||.|||..:...|..:.|:: ::..:..|.:||.:|:||..|::||:..|.:|.:::|||.||
Yeast   538 FEKWAPSLNTIIYKGTPNQRHS-LQHQIRVGNFDVLLTTYEYIIKDKSLLSKHDWAHMIIDEGHR 601

  Fly   261 IKNEKSKLS-EILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFNT---NT 321
            :||.:|||| .|...::|.|||::|||||||||.||||||||:||.:|||::.|::||||   ||
Yeast   602 MKNAQSKLSFTISHYYRTRNRLILTGTPLQNNLPELWALLNFVLPKIFNSAKTFEDWFNTPFANT 666

  Fly   322 CLGDD---------ALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLL 377
            ...:.         .:|.|||.||:||||||||.||||.|..|.|..|...||.:|:..|.::|.
Yeast   667 GTQEKLELTEEETLLIIRRLHKVLRPFLLRRLKKEVEKDLPDKVEKVIKCKLSGLQQQLYQQMLK 731

  Fly   378 KDIDVV----NGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPG--PPYTTDTHLVYN-SGKMAI 435
            .:...|    .||.|.....|.|.:|||||..|||::||..| |  .|...::.|::. :||..:
Yeast   732 HNALFVGAGTEGATKGGIKGLNNKIMQLRKICNHPFVFDEVE-GVVNPSRGNSDLLFRVAGKFEL 795

  Fly   436 LDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAK 500
            ||::|||.:..|.|||:|.|||:::||:||:...::..|.||||.|..|:|...:..||..:|..
Yeast   796 LDRVLPKFKASGHRVLMFFQMTQVMDIMEDFLRMKDLKYMRLDGSTKTEERTEMLNAFNAPDSDY 860

  Fly   501 FLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKI 565
            |.|:|||||||||:||.|||.|||:|:||||..||||.|||||||||.:||:.||||..:|||.|
Yeast   861 FCFLLSTRAGGLGLNLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQKNEVRILRLITTDSVEEVI 925

  Fly   566 VERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEML-NIIRFGANQVFSSKETDITDEDIDVILERG 629
            :|||..||.:|..|||.|:. ||:|....::..| .:|....|:....| .::.|::::..|
Yeast   926 LERAMQKLDIDGKVIQAGKF-DNKSTAEEQEAFLRRLIESETNRDDDDK-AELDDDELNDTL--- 985

  Fly   630 EAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPKRERKA 694
             |::|::|...|.:                              :|:::|       ..:.:.||
Yeast   986 -ARSADEKILFDKI------------------------------DKERMN-------QERADAKA 1012

  Fly   695 NYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKVPKNTE 759
                     :.|||.                      ||||.: ||:....||:.:
Yeast  1013 ---------QGLRVP----------------------PPRLIQ-LDELPKVFREDI--------- 1036

  Fly   760 LGSDATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNIA 824
                      ||..|.:::|||.... |:|......|.|.      .||::|.|.      ||::
Yeast  1037 ----------EEHFKKEDSEPLGRIR-QKKRVYYDDGLTE------EQFLEAVED------DNMS 1078

  Fly   825 KDVEGKTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFHQ 889
            .:...|...|..|...: .:..|:..:||.:....|..|..:....|...|:|::.:..:
Yeast  1079 LEDAIKKRREARERRRL-RQNGTKENEIETLENTPEASETSLIENNSFTAAVDEETNADK----- 1137

  Fly   890 LRLQYGNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQR 954
               :...::.|..:..:.|.:..:..:   ||||..||
Yeast  1138 ---ETTASRSKRRSSRKKRTISIVTAE---DKENTQEE--------------------------- 1169

  Fly   955 RCNTLITLIERENIELEEKER---------AEKKKKAPKGSV--SAGSGSASSNTPAPAPQPKAS 1008
                 .|..|....::||:.:         :|.|||.||.:|  .....:...|......:.|..
Yeast  1170 -----STSQENGGAKVEEEVKSSSVEIINGSESKKKKPKLTVKIKLNKTTVLENNDGKRAEEKPE 1229

  Fly  1009 QKRKSEVVATSSNSKKKK 1026
            .|..::..|......|.|
Yeast  1230 SKSPAKKTAAKKTKTKSK 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	9/36 (25%)
		SNF2_N	131..411	CDD:278600	147/296 (50%)
		DEXDc	148..287	CDD:238005	68/139 (49%)
		HELICc	422..553	CDD:238034	70/131 (53%)
		HAND	697..796	CDD:286232	19/98 (19%)
		SANT	797..838	CDD:197842	9/40 (23%)
		SANT	799..838	CDD:238096	8/38 (21%)
		SLIDE	853..965	CDD:286233	15/111 (14%)
STH1	NP_012140.1	HSA	314..382	CDD:400077	5/25 (20%)
		PLN03142	370..>955	CDD:215601	266/606 (44%)
		SnAC	1006..1069	CDD:405324	24/120 (20%)
		COG5076	<1211..>1359	CDD:227408	6/37 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910