DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and ISW2

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_014948.1	Gene:	ISW2 / 854480	SGDID:	S000005831	Length:	1120	Species:	Saccharomyces cerevisiae

Alignment Length:	1084	Identity:	523/1084 - (48%)
Similarity:	694/1084 - (64%)	Gaps:	99/1084 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TDTAAVEATEENSNE---TTSDAATSSSGEKEAEF---------DNKIEADRSRRFDFLLKQTEI 56
            :|...:..:||.|::   |..|.......:::.:|         ..|.::|..:||.:||..|::
Yeast    36 SDDDNIGQSEELSDKEIYTVEDRPPEYWAQRKKKFVLDVDPKYAKQKDKSDTYKRFKYLLGVTDL 100

  Fly    57 FTHFMTNSAKSPTKPKGRPKKIK--DKDKEKDVADH--------RHRKTEQEEDEELLAE----- 106
            |.||:...||   ..|...|.:|  |.|..|....|        .|||||:|||.||:|:
Yeast   101 FRHFIGIKAK---HDKNIQKLLKQLDSDANKLSKSHSTVSSSSRHHRKTEKEEDAELMADEEEEI 162

  Fly   107 -DSATKEIFRFDASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYL 170
             |:..::|| ...||:::|||::||||::||||:|||:||.::|||||||||||||||||.||||
Yeast   163 VDTYQEDIF-VSESPSFVKSGKLRDYQVQGLNWLISLHENKLSGILADEMGLGKTLQTISFLGYL 226

  Fly   171 KHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSY 235
            ::.|...||.::|||||||.||..||.||.|::..:.|.||:|||...:|::::...:||.:|||
Yeast   227 RYVKQIEGPFLIIVPKSTLDNWRREFLKWTPNVNVLVLHGDKDTRADIVRNIILEARFDVLITSY 291

  Fly   236 EMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLN 300
            ||.||||:..|:..|:|:|||||||||||:|.||:|:|.|.:.||||||||||||||||||||||
Yeast   292 EMVIREKNALKRLAWQYIVIDEAHRIKNEQSALSQIIRLFYSKNRLLITGTPLQNNLHELWALLN 356

  Fly   301 FLLPDVFNSSEDFDEWFNTNTCLGD-DALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGL 364
            |||||:|..||.|||||..|....| :.:|.:||:||.||||||:||:|||.|.||.|..::||:
Yeast   357 FLLPDIFGDSELFDEWFEQNNSEQDQEIVIQQLHSVLNPFLLRRVKADVEKSLLPKIETNVYVGM 421

  Fly   365 SKMQRDWYTKVLLKDIDVVNGA-GKVE-KMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLV 427
            :.||..||..:|.||||.|||| ||.| |.||.||:||||||.||||||:|||||||||||.||:
Yeast   422 TDMQIQWYKSLLEKDIDAVNGAVGKREGKTRLLNIVMQLRKCCNHPYLFEGAEPGPPYTTDEHLI 486

  Fly   428 YNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQE 492
            :|||||.||||||.:|:|:||||||||||:|:||||||||::|::.|||:||.|.||:|...|.|
Yeast   487 FNSGKMIILDKLLKRLKEKGSRVLIFSQMSRLLDILEDYCYFRDFEYCRIDGSTSHEERIEAIDE 551

  Fly   493 FNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLIT 557
            :|..||.||:|:|:||||||||||.|||.||::|||||||.|||||||||||||||||.|:|.:|
Yeast   552 YNKPNSEKFVFLLTTRAGGLGINLVTADTVILFDSDWNPQADLQAMDRAHRIGQKKQVHVYRFVT 616

  Fly   558 ESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDIT-DED 621
            |:.:|||::|||..|||||::|||.|......|...:||::|::|:|||..:|..|.:.:| |.|
Yeast   617 ENAIEEKVIERAAQKLRLDQLVIQQGTGKKTASLGNSKDDLLDMIQFGAKNMFEKKASKVTVDAD 681

  Fly   622 IDVILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIE 686
            ||.||::||.||.|..|...|||...|:.|    || ....|.|::.|:.:::|.. :.:..||.
Yeast   682 IDDILKKGEQKTQELNAKYQSLGLDDLQKF----NG-IENQSAYEWNGKSFQKKSN-DKVVEWIN 740

  Fly   687 PPKRERK---ANYAVDAYFREALRVSEPKA------PKAPRPPKQPIVQDFQFFPPRLFELLDQE 742
            |.:|||:   ..|:||.|::|.:......|      |||||.||....|||||||..|..|.::|
Yeast   741 PSRRERRREQTTYSVDDYYKEIIGGGSKSASKQTPQPKAPRAPKVIHGQDFQFFPKELDALQEKE 805

  Fly   743 IYYFRKTVGYKVP--------KNTELGSDATKVQ----------------------REEQRKIDE 777
            ..||:|.|.|||.        :|.  ||||.:.:                      .|||.||:.
Yeast   806 QLYFKKKVNYKVTSYDITGDIRNE--GSDAEEEEGEYKNAANTEGHKGHEELKRRIEEEQEKINS 868

  Fly   778 AEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNIAKDVEGKTPEEVIEYNAVF 842
            |...|:|:...|:.|:|:.||.|.||||..||.|..||||||::||.|.::.||||||..|..:|
Yeast   869 APDFTQEDELRKQELISKAFTNWNKRDFMAFINACAKYGRDDMENIKKSIDSKTPEEVEVYAKIF 933

  Fly   843 WERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFHQLRLQY-GNNKGKNYTEIE 906
            |||..|:...|:.:..:|.||.|.::....:..|.||:.:.:.|.|:|.:|| .||..:.|..:|
Yeast   934 WERLKEINGWEKYLHNVELGEKKNEKLKFQETLLRQKIEQCKHPLHELIIQYPPNNARRTYNTLE 998

  Fly   907 DRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQRRCNTLITLIERENIELE 971
            |:||:..::|.|...:.:||:|:..|..|..|.||||||:||..||.:|.:||:|||.||    .
Yeast   999 DKFLLLAVNKYGLRADKLYEKLKQEIMMSDLFTFDWFIKTRTVHELSKRVHTLLTLIVRE----Y 1059

  Fly   972 EKERAEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQKRKSEV 1015
            |:..|.|||:           |.:|.|....|..:....|.|.|
Yeast  1060 EQPDANKKKR-----------SRTSATREDTPLSQNESTRASTV 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	12/45 (27%)
		SNF2_N	131..411	CDD:278600	177/282 (63%)
		DEXDc	148..287	CDD:238005	83/138 (60%)
		HELICc	422..553	CDD:238034	94/130 (72%)
		HAND	697..796	CDD:286232	45/134 (34%)
		SANT	797..838	CDD:197842	25/40 (63%)
		SANT	799..838	CDD:238096	23/38 (61%)
		SLIDE	853..965	CDD:286233	44/112 (39%)
ISW2	NP_014948.1	PLN03142	1..1093	CDD:215601	523/1084 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	344	1.000	Domainoid score	I150
eggNOG	1	0.900	-	-		E2759_KOG0385
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55711
Inparanoid	1	1.050	930	1.000	Inparanoid score	I38
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54891
OrthoFinder	1	1.000	-	-		FOG0001113
OrthoInspector	1	1.000	-	-		otm46752
orthoMCL	1	0.900	-	-		OOG6_100877
Panther	1	1.100	-	-	LDO	PTHR10799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2588
SonicParanoid	1	1.000	-	-		X1240
TreeFam	1	0.960	-	-
	13	12.860