DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and ISW1

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_009804.1	Gene:	ISW1 / 852547	SGDID:	S000000449	Length:	1129	Species:	Saccharomyces cerevisiae

Alignment Length:	1012	Identity:	487/1012 - (48%)
Similarity:	673/1012 - (66%)	Gaps:	81/1012 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHFM-TNSAKSP-----------TKPKGRPKKIK 79
            ::|:|   ||  :|. .::||:.||..:.:|.||: :.:||.|           .|..|     |
Yeast    95 ANGKK---FD--LEG-TTKRFEHLLSLSGLFKHFIESKAAKDPKFRQVLDVLEENKANG-----K 148

  Fly    80 DKDKEKDVADHRHRKTEQEEDEELLAEDSATKE---IFRFDASPAYIKSGEMRDYQIRGLNWMIS 141
            .|.|.:||   |.||||.|||.|||.|:.:..:   .|:|..||||: :|::|.|||:|:||::|
Yeast   149 GKGKHQDV---RRRKTEHEEDAELLKEEDSDDDESIEFQFRESPAYV-NGQLRPYQIQGVNWLVS 209

  Fly   142 LYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAV 206
            |::|.|.|||||||||||||||||.||||::.:...||.:||.|||||.||:.|..:|.|.:.|.
Yeast   210 LHKNKIAGILADEMGLGKTLQTISFLGYLRYIEKIPGPFLVIAPKSTLNNWLREINRWTPDVNAF 274

  Fly   207 CLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEI 271
            .|.||::.|...|:..|:..::||.:.|||:.|||||..||.||.|::||||||||||:|.||::
Yeast   275 ILQGDKEERAELIQKKLLGCDFDVVIASYEIIIREKSPLKKINWEYIIIDEAHRIKNEESMLSQV 339

  Fly   272 LREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFNTNTCLGD-DALITRLHAV 335
            ||||.:.|||||||||||||||||||||||||||:|:.::|||:||::.:...| |.::.:||.|
Yeast   340 LREFTSRNRLLITGTPLQNNLHELWALLNFLLPDIFSDAQDFDDWFSSESTEEDQDKIVKQLHTV 404

  Fly   336 LKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVVNGA--GKVEKMRLQNIL 398
            |:||||||:|::||..|.||||:.::||:|.||:.||.|:|.||:|.|||:  .|..|.||.||:
Yeast   405 LQPFLLRRIKSDVETSLLPKKELNLYVGMSSMQKKWYKKILEKDLDAVNGSNGSKESKTRLLNIM 469

  Fly   399 MQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDIL 463
            ||||||.||||||||||||||||||.|||||:.|:.:|||||.||:|:||||||||||:|:||||
Yeast   470 MQLRKCCNHPYLFDGAEPGPPYTTDEHLVYNAAKLQVLDKLLKKLKEEGSRVLIFSQMSRLLDIL 534

  Fly   464 EDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSD 528
            ||||::|||.|||:||.|.||||.:.|.::|..:|.||:|:|:||||||||||.:||||::||||
Yeast   535 EDYCYFRNYEYCRIDGSTAHEDRIQAIDDYNAPDSKKFVFLLTTRAGGLGINLTSADVVVLYDSD 599

  Fly   529 WNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVIQGGRL-VDNRSNQ 592
            ||||.|||||||||||||||||:||||:|:::|||||:|||..|||||::|||..|. :..:.|:
Yeast   600 WNPQADLQAMDRAHRIGQKKQVKVFRLVTDNSVEEKILERATQKLRLDQLVIQQNRTSLKKKENK 664

  Fly   593 L-NKDEMLNIIRFGANQVFSS----------------KETDITDEDIDVILERGEAKTAEQKAAL 640
            . :||.:|::|:.||..||.|                |..||   |:|.:|.:.|.||....|..
Yeast   665 ADSKDALLSMIQHGAADVFKSGTSTGSAGTPEPGSGEKGDDI---DLDELLLKSENKTKSLNAKY 726

  Fly   641 DSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGN-WIEPPKRERKANYAVDAYFRE 704
            ::||...|:.|..|        |.|::.|:|:::|.:.:.:.. .:.|.|||||.||::|.|:::
Yeast   727 ETLGLDDLQKFNQD--------SAYEWNGQDFKKKIQRDIISPLLLNPTKRERKENYSIDNYYKD 783

  Fly   705 ALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKVPKNTELGSDATKVQR 769
            .|.......|..||.||..:....|..||:|..|.::|..:..|..|| ||...::.:....:..
Yeast   784 VLNTGRSSTPSHPRMPKPHVFHSHQLQPPQLKVLYEKERMWTAKKTGY-VPTMDDVKAAYGDISD 847

  Fly   770 EEQRK---------IDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNIAK 825
            ||::|         ::.::||||||.:.|.:..|:|||.|.|.:|.:||..:.||||:.|..||:
Yeast   848 EEEKKQKLELLKLSVNNSQPLTEEEEKMKADWESEGFTNWNKLEFRKFITVSGKYGRNSIQAIAR 912

  Fly   826 DV-EGKTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFHQ 889
            :: .|||.|||..|...||.....::|.|:.:..||..|.||:|....::||.:|:|.|:.||..
Yeast   913 ELAPGKTLEEVRAYAKAFWSNIERIEDYEKYLKIIENEEEKIKRVKMQQEALRRKLSEYKNPFFD 977

  Fly   890 LRLQY---GNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALE 951
            |:|::   .||| :.|:|.||||::.||.|.|.|:::|||.:|..||..|.|..|::.:|||.:|
Yeast   978 LKLKHPPSSNNK-RTYSEEEDRFILLMLFKYGLDRDDVYELVRDEIRDCPLFELDFYFRSRTPVE 1041

  Fly   952 LQRRCNTLITLIERE---NIELEEKERAEKKKKAPKG 985
            |.||.|||:..:|:|   .|.|::..:...||:...|
Yeast  1042 LARRGNTLLQCLEKEFNAGIVLDDATKDRMKKEDENG 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	12/37 (32%)
		SNF2_N	131..411	CDD:278600	168/282 (60%)
		DEXDc	148..287	CDD:238005	81/138 (59%)
		HELICc	422..553	CDD:238034	94/130 (72%)
		HAND	697..796	CDD:286232	30/107 (28%)
		SANT	797..838	CDD:197842	20/41 (49%)
		SANT	799..838	CDD:238096	18/39 (46%)
		SLIDE	853..965	CDD:286233	49/114 (43%)
ISW1	NP_009804.1	PLN03142	108..1057	CDD:215601	476/970 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	344	1.000	Domainoid score	I150
eggNOG	1	0.900	-	-		E2759_KOG0385
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	930	1.000	Inparanoid score	I38
Isobase	1	0.950	-	0	Normalized mean entropy	S3
OMA	1	1.010	-	-		QHG54891
OrthoFinder	1	1.000	-	-		FOG0001113
OrthoInspector	1	1.000	-	-		otm46752
orthoMCL	1	0.900	-	-		OOG6_100877
Panther	1	1.100	-	-	O	PTHR10799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2588
SonicParanoid	1	1.000	-	-		X1240
TreeFam	1	0.960	-	-
	14	13.810