DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and IRC5

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_116696.2	Gene:	IRC5 / 850599	SGDID:	S000001934	Length:	853	Species:	Saccharomyces cerevisiae

Alignment Length:	758	Identity:	255/758 - (33%)
Similarity:	394/758 - (51%)	Gaps:	130/758 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TDTAAVEA--TEENSNETTSDAATSSSGEKEAEFDNKIEADRSRRFDFLLKQTEIFT-------- 58
            :||.||:|  .::.:.:|.|:  ..|..::.:|.|.|..:.:.::.:..::|:::::
Yeast    90 SDTEAVQAQVVDKLAKDTKSE--QKSLDDELSEMDTKTVSLKLKKLNEFVRQSQVYSSIIADTLL 152

  Fly    59 HFMTNSAKSPTKPKGRP-----KKIKDKDKEKDVAD--HRHRKTEQEEDEELLAEDSATKEIFRF 116
            |.....|.:.||.....     ...|.|.|:|.:.|  .:.:|.|....:....:|:|.|:
Yeast   153 HRSNEVANANTKDNSNSDDEEHSSKKRKTKKKSITDFFKKQKKNEDTTTQNGAPDDAAIKQ---- 213

  Fly   117 DASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHI 181
               |..:|:..::.||:.||||:|:|||||:|||||||||||||:|:|:||.::.....: ||.:
Yeast   214 ---PRLLKNCILKPYQLEGLNWLITLYENGLNGILADEMGLGKTVQSIALLAFIYEMDTK-GPFL 274

  Fly   182 VIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQ--DTRNTFIRDVL-MPGEWDVCVTSYEMCIREKS 243
            |..|.|||.||:|||.|:.|.|..:...|..  ..|:..:::.. ..|...:.:||||:.:|:..
Yeast   275 VTAPLSTLDNWMNEFAKFAPDLPVLKYYGTNGYKERSAKLKNFFKQHGGTGIVITSYEIILRDTD 339

  Fly   244 VFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFN 308
            :....||::|::||.||:||...:|.:.|::..|:||||:|||||||||.|||:||||::||:|.
Yeast   340 LIMSQNWKFLIVDEGHRLKNINCRLIKELKKINTSNRLLLTGTPLQNNLAELWSLLNFIMPDIFA 404

  Fly   309 SSEDFDEWFN--------------TNTCLGDDA---LITRLHAVLKPFLLRRLKAEV-EKRLKPK 355
            ..|.|::||:              .|..:.|:.   ||:.||.:||||||||||..| ...|.||
Yeast   405 DFEIFNKWFDFDSLNLGSGSNSEALNKLINDELQKNLISNLHTILKPFLLRRLKKVVLANILPPK 469

  Fly   356 KEMKIFVGLSKMQRDWYT------------KVLLKDIDVVNG-------------------AG-- 387
            :|..|...::..|..:|.            |.|:||...:|.                   :|
Yeast   470 REYIINCPMTSAQEKFYKAGLNGKLKKTMFKELIKDFFTLNDEYIGHVSNRSIRDFINYKLSGNE 534

  Fly   388 -------------------------KVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLV 427
                                     ::...:|||::||||:..:..:||......|...|...|:
Yeast   535 TSNTDNKINPTLLQMDKLYKKNLQMEISNKKLQNMMMQLRQIIDSTFLFYFPYLHPEDLTLETLL 599

  Fly   428 YNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQE 492
            ..|||:.||.||:|.|..:|.:|||:||...|||::||:|...::...|:||...:|.|..|:::
Yeast   600 KTSGKLQILQKLIPPLISEGHKVLIYSQFVNMLDLIEDWCDLNSFATFRIDGSVNNETRKDQLEK 664

  Fly   493 FNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLIT 557
            ||.......:|:|||||.||||||..||.|:::|||||||:|||||||.|||||:..|.|:||..
Yeast   665 FNSSKDKHNIFLLSTRAAGLGINLVGADTVVLFDSDWNPQVDLQAMDRCHRIGQESPVIVYRLCC 729

  Fly   558 ESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDI 622
            ::|:|..|:.||..|..|::||||.|:..:.:...||:...|...:.|.|         :|::|:
Yeast   730 DNTIEHVILTRAANKRNLERMVIQMGKFNNLKKLALNEGSFLKANKAGVN---------VTNKDL 785

  Fly   623 -------------DVILERGEAKTAEQKAALDSLGESSLRTFT 652
                         ::..|.|..|  |.||....|.:..:...|
Yeast   786 VQELSMLLMSDESNIGFENGGQK--ENKATEGQLTDKEVEELT 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	6/44 (14%)
		SNF2_N	131..411	CDD:278600	128/358 (36%)
		DEXDc	148..287	CDD:238005	58/141 (41%)
		HELICc	422..553	CDD:238034	66/130 (51%)
		HAND	697..796	CDD:286232
		SANT	797..838	CDD:197842
		SANT	799..838	CDD:238096
		SLIDE	853..965	CDD:286233
IRC5	NP_116696.2	SNF2_N	225..542	CDD:278600	121/317 (38%)
		DEXDc	242..383	CDD:238005	58/141 (41%)
		Helicase_C	602..717	CDD:278689	60/114 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0385
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810