DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and SMARCA5

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_003592.3	Gene:	SMARCA5 / 8467	HGNCID:	11101	Length:	1052	Species:	Homo sapiens

Alignment Length:	1034	Identity:	738/1034 - (71%)
Similarity:	855/1034 - (82%)	Gaps:	37/1034 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKTDTAAVEATEENSNETTSDAATSSSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHFMTNSA- 65
            |.......:|..|...:..|........|.:..::.|::.||:.||::||||||:|.||:..:|
Human    47 SAASAGPADAEMEEIFDDASPGKQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELFAHFIQPAAQ 111

  Fly    66 KSPTKP----KGRPKKIKDKDKEK--DVADHRHRKTEQEEDEELLAEDS-ATKEIFRFDASPAYI 123
            |:||.|    .||| :||..:|:.  .|.|:|||:||||||||||.|.| ||....||:.||:|:
Human   112 KTPTSPLKMKPGRP-RIKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKATNVCTRFEDSPSYV 175

  Fly   124 KSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKST 188
            |.|::||||:|||||:||||||||||||||||||||||||||||||:||::|..|||:|:|||||
Human   176 KWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKST 240

  Fly   189 LQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRYL 253
            |.||::|||:|.|:||:||||||::.|..|:||||:|||||||||||||.|:|||||||||||||
Human   241 LHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYL 305

  Fly   254 VIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFN 318
            ||||||||||||||||||:|||||.||||:|||||||||||||:||||||||||||::|||.||:
Human   306 VIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWFD 370

  Fly   319 TNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVV 383
            ||.||||..|:.|||.||:||||||:||:|||.|.||||:||:||||||||:|||::|:||||::
Human   371 TNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDIL 435

  Fly   384 NGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGS 448
            |.|||::||||.|||||||||.||||||||||||||||||.|||.|||||.:||||||||:||||
Human   436 NSAGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGS 500

  Fly   449 RVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLG 513
            ||||||||||:||||||||.||||.||||||||||::|...|..:|..||.||:|||||||||||
Human   501 RVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLG 565

  Fly   514 INLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKM 578
            ||||||||||:||||||||:|||||||||||||.|.|||||.||::||||:||||||:|||||.:
Human   566 INLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSI 630

  Fly   579 VIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDVILERGEAKTAEQKAALDSL 643
            |||.|||||...|::.|||||.:||.||..||:|||::|||||||.|||||..||||....|..:
Human   631 VIQQGRLVDQNLNKIGKDEMLQMIRHGATHVFASKESEITDEDIDGILERGAKKTAEMNEKLSKM 695

  Fly   644 GESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPKRERKANYAVDAYFREALRV 708
            ||||||.|||||.     ||||.|||||:|||||: |...|||||||||||||||||||||||||
Human   696 GESSLRNFTMDTE-----SSVYNFEGEDYREKQKI-AFTEWIEPPKRERKANYAVDAYFREALRV 754

  Fly   709 SEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKVPKNTELGSDATKVQREEQR 773
            |||||||||||||||.|||||||||||||||::||.::|||:|||||:|.|| .:|.:.|:|||.
Human   755 SEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILFYRKTIGYKVPRNPEL-PNAAQAQKEEQL 818

  Fly   774 KIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNIAKDVEGKTPEEVIEY 838
            ||||||.|.:||::|||.||:||||.|.|||||||||||||:|||||:|||::||||||||||||
Human   819 KIDEAESLNDEELEEKEKLLTQGFTNWNKRDFNQFIKANEKWGRDDIENIAREVEGKTPEEVIEY 883

  Fly   839 NAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFHQLRLQYGNNKGKNYT 903
            :|||||||.||||||:||.||||||.:||||:|||||||.|:.||:|||||||:.||.|||||||
Human   884 SAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDTKIGRYKAPFHQLRISYGTNKGKNYT 948

  Fly   904 EIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQRRCNTLITLIERENI 968
            |.|||||:||||||||||||||:|||..||.|||||||||:|||||:|||||||||||||||||:
Human   949 EEEDRFLICMLHKLGFDKENVYDELRQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENM 1013

  Fly   969 ELEEKERAEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQKRKSEVVATSSNSKKKKK 1027
            ||||||:|||||:.||.|                     :||||.:........|||.|
Human  1014 ELEEKEKAEKKKRGPKPS---------------------TQKRKMDGAPDGRGRKKKLK 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	16/37 (43%)
		SNF2_N	131..411	CDD:278600	222/279 (80%)
		DEXDc	148..287	CDD:238005	112/138 (81%)
		HELICc	422..553	CDD:238034	106/130 (82%)
		HAND	697..796	CDD:286232	74/98 (76%)
		SANT	797..838	CDD:197842	34/40 (85%)
		SANT	799..838	CDD:238096	32/38 (84%)
		SLIDE	853..965	CDD:286233	91/111 (82%)
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..83		5/35 (14%)
		PLN03142	69..1012	CDD:215601	710/950 (75%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1052		21/58 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	469	1.000	Domainoid score	I458
eggNOG	1	0.900	-	-		E2759_KOG0385
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1488	1.000	Inparanoid score	I103
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54891
OrthoDB	1	1.010	-	-		D144251at33208
OrthoFinder	1	1.000	-	-		FOG0001113
OrthoInspector	1	1.000	-	-		otm41112
orthoMCL	1	0.900	-	-		OOG6_100877
Panther	1	1.100	-	-	O	PTHR10799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2588
SonicParanoid	1	1.000	-	-		X1240
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870