DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and CHR17

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_850847.1	Gene:	CHR17 / 831980	AraportID:	AT5G18620	Length:	1072	Species:	Arabidopsis thaliana

Alignment Length:	1044	Identity:	532/1044 - (50%)
Similarity:	709/1044 - (67%)	Gaps:	83/1044 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKTDTAAVEATEENSNETTSDAATSSSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHFMTNSA 65
            :||.:.|.::..::...:.......|.:...:|:.:||.:.    |..:||:|||:|.|| ..|.
plant    81 ISKREKARLKEMQKMKKQKIQQILDSQNASIDADMNNKGKG----RIKYLLQQTELFAHF-AKSD 140

  Fly    66 KSPTKPKGRPKKIKDKDKEKDVADHRHRKTEQEEDEELLAED-------SATKEIFRFDASPAYI 123
            .||::.||:.:           ..|..:.||:|||||.|.|:       ..|    |....||.|
plant   141 PSPSQKKGKGR-----------GRHSSKLTEEEEDEECLKEEEGGIVGSGGT----RLLTQPACI 190

  Fly   124 KSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKST 188
            : |::||||:.||||:|.||||||||||||||||||||||||||.||..::...|||:|:.||||
plant   191 Q-GKLRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLAYLHEYRGINGPHMVVAPKST 254

  Fly   189 LQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRYL 253
            |.||:||.:::||.||||..:|:.:.|.....::|:.|::|:||||:||.|:||:..::|:|||:
plant   255 LGNWMNEIRRFCPVLRAVKFLGNPEERRHIREELLVAGKFDICVTSFEMAIKEKTTLRRFSWRYI 319

  Fly   254 VIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFN 318
            :||||||||||.|.||:.:|.|.|..|||||||||||||||||||||||||:||:|:|.|||||.
plant   320 IIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEVFSSAETFDEWFQ 384

  Fly   319 TNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVV 383
            .:.......::.:||.||:||||||||::|||.|.||||..:.||:|:||:.:|..:|.||::||
plant   385 ISGENDQQEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLEVV 449

  Fly   384 NGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGS 448
            ||.|  |:.||.||.||||||.||||||.||||||||||..|||.|:|||.:||||||||:::.|
plant   450 NGGG--ERKRLLNIAMQLRKCCNHPYLFQGAEPGPPYTTGDHLVTNAGKMVLLDKLLPKLKDRDS 512

  Fly   449 RVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLG 513
            ||||||||||:|||||||..:|.|.|||:||.|..::|:..|:.:|...|.||:|:|||||||||
plant   513 RVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGDERDASIEAYNKPGSEKFVFLLSTRAGGLG 577

  Fly   514 INLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKM 578
            ||||||||||:||||||||:||||.||||||||||:|:|||..||:.:|.|::|||..||.||.:
plant   578 INLATADVVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTENAIEAKVIERAYKKLALDAL 642

  Fly   579 VIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDVILERGEAKTAEQKAALDSL 643
            |||.|||.:.::  :||||:|.::|:||..|||||::.|||||||.|:.:||..|||..|.:...
plant   643 VIQQGRLAEQKT--VNKDELLQMVRYGAEMVFSSKDSTITDEDIDRIIAKGEEATAELDAKMKKF 705

  Fly   644 GESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLN----ALGNWIEPPKRERKANYAVDAYFRE 704
            .|.::: |.||.:.:     .|.|: :|.:::.|::    ...||.:|||||||.||:...||::
plant   706 TEDAIQ-FKMDDSAD-----FYDFD-DDNKDESKVDFKKIVSENWNDPPKRERKRNYSEVEYFKQ 763

  Fly   705 ALRVSEPKAPKAPRPPKQPIVQDFQFFP-PRLFELLDQEIYYFRKTVGYKVPKNTELGSDATKVQ 768
            .||...|..||.||.|:.|.:.|||||. .||.||.::|:.|..:.              ..|.|
plant   764 TLRQGAPAKPKEPRIPRMPQLHDFQFFNIQRLTELYEKEVRYLMQA--------------HQKTQ 814

  Fly   769 REEQRKIDEAE----PLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNIAKDVEG 829
            .::..::||.|    |||.||::|||.||.:||:.|::||||.||:|.|||||:||.:||.::||
plant   815 MKDTIEVDEPEEVGDPLTAEEVEEKELLLEEGFSTWSRRDFNAFIRACEKYGRNDIKSIASEMEG 879

  Fly   830 KTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFHQLRLQY 894
            ||.|||..|..||..|..||.|.:||:..|||||.:|.|:..|.||:.:|:.|||.|:.:|::||
plant   880 KTEEEVERYAQVFQVRYKELNDYDRIIKNIERGEARISRKDEIMKAIGKKLDRYRNPWLELKIQY 944

  Fly   895 GNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQRRCNTL 959
            |.||||.|.|..|||::||:||||:..   ::||:||.|.||.||||||:||||..||.|||:||
plant   945 GQNKGKLYNEECDRFMICMVHKLGYGN---WDELKAAFRTSPLFRFDWFVKSRTTQELARRCDTL 1006

  Fly   960 ITLIERENIELEEKER-AEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQKRKSEVVATSSNSK 1023
            |.|||:||.|.:|:|| |.|:||..|.:             .|:.:|...|..:|    .||..|
plant  1007 IRLIEKENQEFDERERQARKEKKLSKSA-------------TPSKRPSGRQANES----PSSLLK 1054

  Fly  1024 KKKK 1027
            |:|:
plant  1055 KRKQ 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	13/36 (36%)
		SNF2_N	131..411	CDD:278600	171/279 (61%)
		DEXDc	148..287	CDD:238005	81/138 (59%)
		HELICc	422..553	CDD:238034	91/130 (70%)
		HAND	697..796	CDD:286232	37/103 (36%)
		SANT	797..838	CDD:197842	25/40 (63%)
		SANT	799..838	CDD:238096	24/38 (63%)
		SLIDE	853..965	CDD:286233	63/111 (57%)
CHR17	NP_850847.1	PLN03142	19..1056	CDD:215601	530/1040 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	343	1.000	Domainoid score	I238
eggNOG	1	0.900	-	-		E2759_KOG0385
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	984	1.000	Inparanoid score	I45
OMA	1	1.010	-	-		QHG54891
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	1	1.000	-	-		FOG0001113
OrthoInspector	1	1.000	-	-		otm2627
orthoMCL	1	0.900	-	-		OOG6_100877
Panther	1	1.100	-	-	O	PTHR10799
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1240
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840