DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and CHR11

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001189826.1	Gene:	CHR11 / 819814	AraportID:	AT3G06400	Length:	1057	Species:	Arabidopsis thaliana

Alignment Length:	1032	Identity:	532/1032 - (51%)
Similarity:	708/1032 - (68%)	Gaps:	75/1032 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKTDTAAVEATEENSNETTSDAATSSSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHF-MTNS 64
            :||.:.|.::..::...:...:...|.:...:|:.:||.:.    |..:||:|||:|.|| .::.
plant    76 ISKREKARLKEMQKLKKQKIQEMLESQNASIDADMNNKGKG----RLKYLLQQTELFAHFAKSDG 136

  Fly    65 AKSPTKPKGRPKKIKDKDKEKDVADHRHRKTEQEEDEELL--AEDSAT-KEIFRFDASPAYIKSG 126
            :.|..|.|||.:             |..:.||:|||||.|  .||..| ....|....|:.|: |
plant   137 SSSQKKAKGRGR-------------HASKITEEEEDEEYLKEEEDGLTGSGNTRLLTQPSCIQ-G 187

  Fly   127 EMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQN 191
            :|||||:.||||:|.||||||||||||||||||||||||||.||..::...|||:|:.|||||.|
plant   188 KMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLAYLHEYRGINGPHMVVAPKSTLGN 252

  Fly   192 WVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRYLVID 256
            |:||.:::||.||||..:|:.:.|.....|:|:.|::|:||||:||.|:||:..::|:|||::||
plant   253 WMNEIRRFCPVLRAVKFLGNPEERRHIREDLLVAGKFDICVTSFEMAIKEKTALRRFSWRYIIID 317

  Fly   257 EAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFNTNT 321
            ||||||||.|.||:.:|.|.|..|||||||||||||||||||||||||::|:|:|.|||||..:.
plant   318 EAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISG 382

  Fly   322 CLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVVNGA 386
            ......::.:||.||:||||||||::|||.|.||||..:.||:|:||:.:|..:|.||::.||..
plant   383 ENDQQEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLEAVNAG 447

  Fly   387 GKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGSRVL 451
            |  |:.||.||.||||||.||||||.||||||||||..||:.|:|||.:||||||||:|:.||||
plant   448 G--ERKRLLNIAMQLRKCCNHPYLFQGAEPGPPYTTGDHLITNAGKMVLLDKLLPKLKERDSRVL 510

  Fly   452 IFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINL 516
            |||||||:|||||||..:|.|.|||:||.|..::|:..|:.:|...|.||:|:||||||||||||
plant   511 IFSQMTRLLDILEDYLMYRGYLYCRIDGNTGGDERDASIEAYNKPGSEKFVFLLSTRAGGLGINL 575

  Fly   517 ATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVIQ 581
            |||||||:||||||||:||||.||||||||||:|:|||..|||.:|||::|||..||.||.:|||
plant   576 ATADVVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTESAIEEKVIERAYKKLALDALVIQ 640

  Fly   582 GGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDVILERGEAKTAEQKAALDSLGES 646
            .|||.:.::  :||||:|.::|:||..|||||::.|||||||.|:.:||..|||..|.:....|.
plant   641 QGRLAEQKT--VNKDELLQMVRYGAEMVFSSKDSTITDEDIDRIIAKGEEATAELDAKMKKFTED 703

  Fly   647 SLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLN----ALGNWIEPPKRERKANYAVDAYFREALR 707
            ::: |.||   ::..:..|.|: :|.:::.||:    ...||.:|||||||.||:...||::.||
plant   704 AIQ-FKMD---DSKGADFYDFD-DDNKDENKLDFKKIVSDNWNDPPKRERKRNYSESEYFKQTLR 763

  Fly   708 VSEPKAPKAPRPPKQPIVQDFQFFP-PRLFELLDQEIYYFRKTVGYKVPKNTELGSDATKVQREE 771
            ...|..||.||.|:.|.:.|||||. .||.||.::|:.|..:|              ..|.|.::
plant   764 QGAPAKPKEPRIPRMPQLHDFQFFNIQRLTELYEKEVRYLMQT--------------HQKNQLKD 814

  Fly   772 QRKIDEAE---PLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNIAKDVEGKTPE 833
            ...::|.|   |||.||::|||.||.:||:.|::||||.|::|.|||||:||.:||.::||||.|
plant   815 TIDVEEPEGGDPLTTEEVEEKEGLLEEGFSTWSRRDFNTFLRACEKYGRNDIKSIASEMEGKTEE 879

  Fly   834 EVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFHQLRLQYGNNK 898
            ||..|..||.||..||.|.:||:..|||||.:|.|:..|.||:.:|:.|||.|:.:|::|||.||
plant   880 EVERYAKVFKERYKELNDYDRIIKNIERGEARISRKDEIMKAIGKKLDRYRNPWLELKIQYGQNK 944

  Fly   899 GKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQRRCNTLITLI 963
            ||.|.|..|||::||:||||:..   ::||:||.|.|..||||||:||||:.||.|||:|||.||
plant   945 GKLYNEECDRFMICMIHKLGYGN---WDELKAAFRTSSVFRFDWFVKSRTSQELARRCDTLIRLI 1006

  Fly   964 ERENIELEEKER-AEKKKKAPKGSVSAGSGSASSNTPAPAP-------QPKASQKRK 1012
            |:||.|.:|:|| |.|:||.           |.|.||:..|       .|.:::|||
plant  1007 EKENQEFDERERQARKEKKL-----------AKSATPSKRPLGRQASESPSSTKKRK 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	12/37 (32%)
		SNF2_N	131..411	CDD:278600	169/279 (61%)
		DEXDc	148..287	CDD:238005	82/138 (59%)
		HELICc	422..553	CDD:238034	91/130 (70%)
		HAND	697..796	CDD:286232	37/102 (36%)
		SANT	797..838	CDD:197842	24/40 (60%)
		SANT	799..838	CDD:238096	23/38 (61%)
		SLIDE	853..965	CDD:286233	62/111 (56%)
CHR11	NP_001189826.1	PLN03142	33..1052	CDD:215601	530/1030 (51%)
		DEXDc	209..348	CDD:238005	82/138 (59%)
		Helicase_C	505..604	CDD:278689	69/98 (70%)
		HAND	756..>827	CDD:286232	27/84 (32%)
		SANT	845..889	CDD:238096	25/43 (58%)
		SLIDE	899..1008	CDD:286233	62/111 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	343	1.000	Domainoid score	I238
eggNOG	1	0.900	-	-		E2759_KOG0385
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	984	1.000	Inparanoid score	I45
OMA	1	1.010	-	-		QHG54891
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	1	1.000	-	-		FOG0001113
OrthoInspector	1	1.000	-	-		otm2627
orthoMCL	1	0.900	-	-		OOG6_100877
Panther	1	1.100	-	-	LDO	PTHR10799
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1240
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840