DRSC/TRiP Functional Genomics Resources

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Protein Alignment Iswi and Chd6

DIOPT Version :10

Sequence 1:NP_523719.1 Gene:Iswi / 36390 FlyBaseID:FBgn0011604 Length:1027 Species:Drosophila melanogaster
Sequence 2:NP_775544.2 Gene:Chd6 / 71389 MGIID:1918639 Length:2711 Species:Mus musculus


Alignment Length:1173 Identity:331/1173 - (28%)
Similarity:518/1173 - (44%) Gaps:265/1173 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 ATSSSGEKEAEFDNKIEADRSRR---------------------FDFLLKQT--------EIFTH 59
            ||....||:.....||:..|:::                     .|.:|:..        |..||
Mouse   332 ATMEELEKDPRIAQKIKRFRNKQAQMKHIFTEPDEDLFNPDYIEIDRILEVAHTKDAETGEEVTH 396

  Fly    60 FMTNSAKSPTKPKG-------RPKKIKDKDKEKDVADHRHRKTEQEEDEELLAEDSATKEIFRFD 117
            ::......|.:...       .|.|:|:.:..:.:.:.:|            .|..|:....:.:
Mouse   397 YLVKWCSLPYEESTWELEEDVDPAKVKEFESLQILPEVKH------------VERPASDAWQKLE 449

  Fly   118 ASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIV 182
            .|..|..|..:|:||:.|:||::..:.|..|.|||||||||||:|:|:.|..: ..:...||.::
Mouse   450 TSREYRNSNRLREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSIAFLSEI-FVRGIHGPFLI 513

  Fly   183 IVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTF------IRDVL---MPG--EWDVCVTSYE 236
            |.|.||:.||..||:.| ..:.|:...|.|.:|...      .||..   :.|  ::.|.:|::|
Mouse   514 IAPLSTITNWEREFRTW-TEMNAIVYHGSQISRQMIQQYEMVYRDAQGNPLSGVFKFHVVITTFE 577

  Fly   237 MCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNF 301
            |.:.:....||.:|..::||||||:||...||.|.|:.....:::|:|||||||::.||::||||
Mouse   578 MILADCPELKKIHWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNF 642

  Fly   302 LLPDVFNSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSK 366
            |.|..|.|...|.|.|..   |..:..:.:|.::|||.:|||||.:|||.|.||:|..|.|.|:.
Mouse   643 LEPSQFPSETAFLEEFGD---LKTEEQVKKLQSILKPMMLRRLKDDVEKNLAPKQETIIEVELTN 704

  Fly   367 MQRDWYTKVLLKDID-VVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEP------GPPYTTDT 424
            :|:.:|..:|.|:.. :..||.:.....|.|.:|:||||.|||||.:|||.      ...::::.
Mouse   705 IQKKYYRAILEKNFSFLTKGANQHNMPNLINTMMELRKCCNHPYLINGAEEKILEDFRKAHSSEA 769

  Fly   425 H------LVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPH 483
            .      ::..:||:.::|||||||...|.:|||||||.|.|||||||...|.|.|.|:||:...
Mouse   770 SDFQLQAMIQAAGKLVLIDKLLPKLIAGGHKVLIFSQMVRCLDILEDYLIQRRYTYERIDGRVRG 834

  Fly   484 EDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKK 548
            ..|...|..|...:|.:|:|:|.||||||||||..||..||:|||||||.||||..|.|||||.|
Mouse   835 NLRQAAIDRFCKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSK 899

  Fly   549 QVRVFRLITESTVEEKIVERAEVKLRLDKMVIQ--GGRLVDNRSNQLNKDEMLNIIRFGANQVFS 611
            .|:|:||||.::.|.::.::|.:||.|||.::|  ..:...|...||:|.|:.:::|.||.....
Mouse   900 AVKVYRLITRNSYEREMFDKASLKLGLDKAILQDINRKGSTNGVQQLSKMEVEDLLRKGAYGALM 964

  Fly   612 SKETD---ITDEDIDVILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWR 673
            .:|.:   ..:||||.||:|                  ...|.|:.:.|:..|.:...|.....|
Mouse   965 DEEDEGSKFCEEDIDQILQR------------------RTHTITIQSEGKGSTFAKASFVASGNR 1011

  Fly   674 EKQKL---NALGNWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRL 735
            ....|   |....|.:..:.:.:||..     :|:|.:..|:..|..:....             
Mouse  1012 TDISLDDPNFWQKWAKIAELDTEANNE-----KESLVIDRPRVRKQTKHYNS------------- 1058

  Fly   736 FELLDQEIYYFRKTVGYKVPKNTELGSDATKVQREEQRKIDEAEP-LTEEEIQEKENLLSQGFTA 799
            ||  :.|:..|           :||.||:.:.....:|..|.|.. |..|..:.::|||..|:..
Mouse  1059 FE--EDELMEF-----------SELDSDSDERPTRSRRLSDRARRYLRAECFRVEKNLLIFGWGR 1110

  Fly   800 W-------------TKRDFNQFIKANEKYGRDDIDNIAKDVEGKTPEEVIEYNAVFWERCT---- 847
            |             .::|.....:|...|       ..|..:|   :|.|:  :..||..|    
Mouse  1111 WKDILTHGRFKWPLNEKDMEMICRALLVY-------CVKHYKG---DEKIK--SFIWELITPSKD 1163

  Fly   848 ----ELQDIERIMGQIERGE--GKIQRRLSI-----------------------KKALDQKMSRY 883
                .||:...:...:.||.  .|.:.:|.:                       ||.|.|..::.
Mouse  1164 GQVQTLQNHSGLSAPVPRGRKGKKTKNQLLLPELKNADWLATCNPEVVLHDDGYKKHLKQHCNKV 1228

  Fly   884 RAPFHQLRLQY-------GNNKGK-----------------NYTEI--------EDRFLVCMLHK 916
               ..::|:.|       |....|                 :|.||        .|:.|:..:.|
Mouse  1229 ---LLRVRMLYYLKAEILGEAADKAFEGTPARELDVLLPDIDYVEIPVDWWDAEADKSLLIGVFK 1290

  Fly   917 LGFDKENVYEELRAAIRASPQFRFDWFI-----KSRTA--------LELQRRCNTLITLIERENI 968
            .|:::.|       |:||.|...|...:     ||.:|        .::..|.|     |::|:.
Mouse  1291 HGYERYN-------AMRADPALCFLEKVGMPDEKSLSAEQGVTDGTSDIPERGN-----IDKEDS 1343

  Fly   969 ELEEKERAEKKKKAPK------------GSVSAGSGSASSNTPAPAPQPKASQKRKSEVVATSSN 1021
            ..::.:..:|:..:|.            .|.:|..||....:|.|......::.|:...:....|
Mouse  1344 AEDKLDGLQKQTASPSDGSDGIFGEKKDDSQAAQDGSDPDKSPWPVSSALTARLRRLVTIYQRCN 1408

  Fly  1022 SKK 1024
            .|:
Mouse  1409 RKE 1411

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IswiNP_523719.1 PLN03142 46..967 CDD:215601 312/1080 (29%)
Chd6NP_775544.2 Required for DNA-dependent ATPase activity. /evidence=ECO:0000250 1..746 135/430 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 66..243
PTZ00449 <101..372 CDD:185628 7/39 (18%)
CD1_tandem_CHD5-9_like 287..352 CDD:349315 6/19 (32%)
CD2_tandem_CHD5-9_like 371..429 CDD:349310 9/57 (16%)
PLN03142 459..>984 CDD:215601 220/529 (42%)
DEAD-like_helicase_N 460..681 CDD:475120 86/225 (38%)
DEAH box 597..600 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1318..1389 13/75 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1951..1978
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1997..2059
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2124..2147
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2321..2350
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2373..2419
BRK 2402..2435 CDD:470653
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2550..2602
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2641..2711
Blue background indicates that the domain is not in the aligned region.

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