DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Iswi and SMARCA1

DIOPT Version :9

Sequence 1:NP_523719.1 Gene:Iswi / 36390 FlyBaseID:FBgn0011604 Length:1027 Species:Drosophila melanogaster
Sequence 2:NP_001269803.1 Gene:SMARCA1 / 6594 HGNCID:11097 Length:1070 Species:Homo sapiens


Alignment Length:1049 Identity:739/1049 - (70%)
Similarity:863/1049 - (82%) Gaps:55/1049 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 TAAVEATEENSNETTSD-----AATSSSGEKE--AEFDNKIEADRSRRFDFLLKQTEIFTHFMTN 63
            |||.|..|:...:..|.     ||.:...|||  .|::.|::|||::||:|||||||:|.||:..
Human    47 TAATEKGEKKKEKNVSSFQLKLAAKAPKSEKEMDPEYEEKMKADRAKRFEFLLKQTELFAHFIQP 111

  Fly    64 SA-KSPTKP----KGRPKKIKDKDKEK--DVADHRHRKTEQEEDEELLAEDSATKEI-FRFDASP 120
            || ||||.|    .||| :||..:|:.  ...|:|||:||||||||||:|...|..: .||:.||
Human   112 SAQKSPTSPLNMKLGRP-RIKKDEKQSLISAGDYRHRRTEQEEDEELLSESRKTSNVCIRFEVSP 175

  Fly   121 AYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVP 185
            :|:|.|.:||||||||||:|||||||:|||||||||||||||||:|||||||::|..|||:|:||
Human   176 SYVKGGPLRDYQIRGLNWLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVP 240

  Fly   186 KSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNW 250
            ||||.||:||||:|.||||.:|.:||:|.|..||||.:||||||||||||||.|:||||||||:|
Human   241 KSTLHNWMNEFKRWVPSLRVICFVGDKDARAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFKKFHW 305

  Fly   251 RYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDE 315
            |||||||||||||||||||||:||||:.||||:||||||||||||||||||||||||||::|||.
Human   306 RYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDS 370

  Fly   316 WFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDI 380
            ||:|..||||..|:.|||||||||||||:|.:|||.|.||||:||::|||||||:||||:|:|||
Human   371 WFDTKNCLGDQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDI 435

  Fly   381 DVVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQE 445
            ||:|.:||::||||.|||||||||.||||||||||||||||||.|:|.|||||.:|||||.||:|
Human   436 DVLNSSGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSNSGKMVVLDKLLAKLKE 500

  Fly   446 QGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDR------------NRQIQEFNMDNS 498
            |||||||||||||:||||||||.||.|.|||||||||||:|            ...|:.||..||
Human   501 QGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEAFNAPNS 565

  Fly   499 AKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEE 563
            :||:|||||||||||||||:|||||:||||||||:|||||||||||||||.||||||||::||||
Human   566 SKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEE 630

  Fly   564 KIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDVILER 628
            :||||||:|||||.:|||.|||:|.:||:|.|:|||.:||.||..||:|||:::|||||..||||
Human   631 RIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFASKESELTDEDITTILER 695

  Fly   629 GEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPKRERK 693
            ||.||||....|..:||||||.|.||..     .|:|:|||||:||||||..: .||||||||||
Human   696 GEKKTAEMNERLQKMGESSLRNFRMDIE-----QSLYKFEGEDYREKQKLGMV-EWIEPPKRERK 754

  Fly   694 ANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKVPKNT 758
            |||||||||||||||||||.||||||||||.|||||||||||||||::||.|:|||:|||||:|.
Human   755 ANYAVDAYFREALRVSEPKIPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRNP 819

  Fly   759 ELGSDATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNI 823
            ::.:.|. .|||||:|||.|||||.||.:|||.||:||||.||||||||||||||||||||||||
Human   820 DIPNPAL-AQREEQKKIDGAEPLTPEETEEKEKLLTQGFTNWTKRDFNQFIKANEKYGRDDIDNI 883

  Fly   824 AKDVEGKTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFH 888
            |::||||:||||:||:|||||||.||||||:||.||||||.:||||:|||||||.|::||:||||
Human   884 AREVEGKSPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAPFH 948

  Fly   889 QLRLQYGNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQ 953
            |||:|||.:|||||||.|||||:|||||:|||:||||||||..:|.:||||||||||||||:|.|
Human   949 QLRIQYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEELRQCVRNAPQFRFDWFIKSRTAMEFQ 1013

  Fly   954 RRCNTLITLIERENIELEEKERAEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQKRKSEVVAT 1018
            |||||||:|||:||:|:||:|||||||:|.|             ||       .|||||:|....
Human  1014 RRCNTLISLIEKENMEIEERERAEKKKRATK-------------TP-------MSQKRKAESATE 1058

  Fly  1019 SSNSKKKKK 1027
            ||..|..||
Human  1059 SSGKKDVKK 1067

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IswiNP_523719.1 DBINO <30..67 CDD:290603 22/39 (56%)
SNF2_N 131..411 CDD:278600 221/279 (79%)
DEXDc 148..287 CDD:238005 110/138 (80%)
HELICc 422..553 CDD:238034 105/142 (74%)
HAND 697..796 CDD:286232 74/98 (76%)
SANT 797..838 CDD:197842 35/40 (88%)
SANT 799..838 CDD:238096 33/38 (87%)
SLIDE 853..965 CDD:286233 87/111 (78%)
SMARCA1NP_001269803.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 25..82 11/34 (32%)
PLN03142 87..1069 CDD:215601 726/1009 (72%)
DEAH box 311..314 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..849 16/30 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157854
Domainoid 1 1.000 469 1.000 Domainoid score I458
eggNOG 1 0.900 - - E2759_KOG0385
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55711
Inparanoid 1 1.050 1488 1.000 Inparanoid score I103
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54891
OrthoDB 1 1.010 - - D144251at33208
OrthoFinder 1 1.000 - - FOG0001113
OrthoInspector 1 1.000 - - otm41112
orthoMCL 1 0.900 - - OOG6_100877
Panther 1 1.100 - - LDO PTHR10799
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2588
SonicParanoid 1 1.000 - - X1240
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

Return to query results.
Submit another query.