DRSC/TRiP Functional Genomics Resources

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Protein Alignment Iswi and CHD8

DIOPT Version :10

Sequence 1:NP_523719.1 Gene:Iswi / 36390 FlyBaseID:FBgn0011604 Length:1027 Species:Drosophila melanogaster
Sequence 2:NP_001164100.1 Gene:CHD8 / 57680 HGNCID:20153 Length:2581 Species:Homo sapiens


Alignment Length:1064 Identity:321/1064 - (30%)
Similarity:486/1064 - (45%) Gaps:237/1064 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 ATSSSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTH--------------FMTNSAKSPTKPKGR 74
            ||.|..||:.....|:     :||...:.|...|.|              .:.:.:.|..|..|.
Human   683 ATISQLEKDKRIHQKL-----KRFKTKMAQMRHFFHEDEEPFNPDYVEVDRILDESHSIDKDNGE 742

  Fly    75 PK-----------------KIKDKDKEKDVADHRHRKTEQEEDEEL-LAEDSATKEIFRFDASPA 121
            |.                 ::|:...|..:.:.:..::...|.:.: ..:.||.|::   :.|..
Human   743 PVIYYLVKWCSLPYEDSTWELKEDVDEGKIREFKRIQSRHPELKRVNRPQASAWKKL---ELSHE 804

  Fly   122 YIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQA--GPHIVIV 184
            |....::|:||:.|:||::..:.|..|.|||||||||||:|:|:   :|:...|..  ||.:||.
Human   805 YKNRNQLREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIA---FLQEVYNVGIHGPFLVIA 866

  Fly   185 PKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTF---------IRDVLMPG--EWDVCVTSYEMC 238
            |.||:.||..||..| ..:..:...|...:|...         .|..|:||  ::|..:|::||.
Human   867 PLSTITNWEREFNTW-TEMNTIVYHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMI 930

  Fly   239 IREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLL 303
            :.:....::..||.::||||||:||...||.:.|:.....:::|:|||||||.:.||::||:||.
Human   931 LSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLE 995

  Fly   304 PDVFNSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQ 368
            |..|.|..:|.:.|..   |..:..:.:|.|:|||.:|||||.:|||.|.||:|..|.|.|:.:|
Human   996 PSQFPSESEFLKDFGD---LKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQ 1057

  Fly   369 RDWYTKVLLKDIDVVN-GAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPG-----------PPYT 421
            :.:|..:|.|:...:: |||......|.|.:|:||||.|||||.:|||..           .|: 
Human  1058 KKYYRAILEKNFSFLSKGAGHTNMPNLLNTMMELRKCCNHPYLINGAEEKILTEFREACHIIPH- 1121

  Fly   422 TDTHL---VYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPH 483
             |.||   |.::||:.::|||||||:..|.:|||||||.|.|||||||...|.|.|.|:||:...
Human  1122 -DFHLQAMVRSAGKLVLIDKLLPKLKAGGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRVRG 1185

  Fly   484 EDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKK 548
            ..|...|..|:..:|.:|:|:|.||||||||||..||..||:|||||||.||||..|.|||||.|
Human  1186 NLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSK 1250

  Fly   549 QVRVFRLITESTVEEKIVERAEVKLRLDKMVIQ--GGRLVDNR---SNQLNKDEMLNIIRFGANQ 608
            .|:|:||||.::.|.::.::|.:||.|||.|:|  .||  |..   ..|.:|.|:.:::|.||..
Human  1251 AVKVYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGR--DGNITGIQQFSKKEIEDLLRKGAYA 1313

  Fly   609 VFSSKETD---ITDEDIDVILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGE 670
            ....::.:   ..:||||.||.|   :|.               |.|:::.|:..|.:...|...
Human  1314 AIMEEDDEGSKFCEEDIDQILLR---RTT---------------TITIESEGKGSTFAKASFVAS 1360

  Fly   671 DWREKQKLNALGNWIEPPKRERKANYAVDAY-FREALRVSEPKAPKAPRPPKQPIVQDFQFFPPR 734
            :.|....|:....|   .|..:||:..:|.. .:..|.:..|:..|..|               .
Human  1361 ENRTDISLDDPNFW---QKWAKKADLDMDLLNSKNNLVIDTPRVRKQTR---------------H 1407

  Fly   735 LFELLDQEIYYFRKTVGYKVPKNTELGSDATKVQREEQRKIDEAEPLTEEE-IQEKENLLSQGFT 798
            ...|.|.::..|           ::|.|:..  :|...|:.|........: .:.:::||..|:.
Human  1408 FSTLKDDDLVEF-----------SDLESEDD--ERPRSRRHDRHHAYGRTDCFRVEKHLLVYGWG 1459

  Fly   799 AW-------------TKRDFNQFIKANEKY------GRDDI-----DNIAKDVEGKTPEEVIEYN 839
            .|             |:||.....:|...|      |.::|     |.|:....|||        
Human  1460 RWRDILSHGRFKRRMTERDVETICRAILVYCLLHYRGDENIKGFIWDLISPAENGKT-------- 1516

  Fly   840 AVFWERCTELQDIERIMGQIERG----EGKIQRRLSIKKA----------LDQKMSRYRAPFHQ- 889
                   .|||:...:...:.||    :.|.|....|.||          |.|..|..:...|| 
Human  1517 -------KELQNHSGLSIPVPRGRKGKKVKSQSTFDIHKADWIRKYNPDTLFQDESYKKHLKHQC 1574

  Fly   890 ------LRLQY-------GNNK-----GKNYTEIE--------------------DRFLVCMLHK 916
                  :|:.|       |:..     |...:||:                    |:.|:..:.|
Human  1575 NKVLLRVRMLYYLRQEVIGDQAEKVLGGAIASEIDIWFPVVDQLEVPTTWWDSEADKSLLIGVFK 1639

  Fly   917 LGFDKENVYEELRAAIRASPQFRF 940
            .|::|.|       .:||.|...|
Human  1640 HGYEKYN-------TMRADPALCF 1656

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IswiNP_523719.1 PLN03142 46..967 CDD:215601 315/1042 (30%)
CHD8NP_001164100.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..114
PHA03247 <68..280 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..283
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..392
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..582
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..615
CD1_tandem_CHD5-9_like 638..703 CDD:349315 8/24 (33%)
CD2_tandem_CHD5-9_like 721..779 CDD:349310 6/57 (11%)
PLN03142 810..>1409 CDD:215601 243/645 (38%)
DEXHc_CHD8 811..1032 CDD:350818 84/227 (37%)
DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03071 948..951 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1692..1712
Interaction with FAM124B. /evidence=ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:23285124 1789..2302
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1991..2116
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2189..2229
BRK 2310..2354 CDD:197800
BRK 2379..2419 CDD:197800
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2481..2581
Blue background indicates that the domain is not in the aligned region.

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