DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and smarcad1b

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	XP_005155692.3	Gene:	smarcad1b / 563175	ZFINID:	ZDB-GENE-091113-61	Length:	955	Species:	Danio rerio

Alignment Length:	657	Identity:	229/657 - (34%)
Similarity:	334/657 - (50%)	Gaps:	104/657 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TEENSNETTSDAATSSSGEKEAEFDNKIEADRSRRFDFLLK-QTEIFTHFMTNSAKSPTKPKGRP 75
            |..:|.|..||:..|       ..:..:::|..:..:.|.| :|||...|.:.|....|...|..
Zfish   285 TYVSSEEECSDSEAS-------VVNGLLDSDSDQSEETLSKLKTEILCFFQSASVDELTLIAGCS 342

  Fly    76 KKIKDKDKE-------KDVADHRHRKTEQEED-----EELLAEDSATKEIFR------------- 115
            .|...|..|       ||:.|...|:.....:     .|:|.|....|.:..
Zfish   343 LKKAQKITELRPFKTWKDLDDAMRRRNGLSAELLAGCREVLKEREVVKGLMSKCEEISVKLIQDV 407

  Fly   116 ---FDASPAYIKSGE-------MRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYL 170
               .|..|..:...|       ::.||:.||||::.|::|.::||||||||||||:|.||.|.:|
Zfish   408 TQVMDKGPGSMTQPEILSSTFQLKPYQLIGLNWLVLLHQNKLSGILADEMGLGKTIQAISFLAHL 472

  Fly   171 KHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVL-MPGEWDVCVTS 234
            ....|. |||::.||.|||.|||.|...||||.:.:...|..|.|.....::| ...|:::.|::
Zfish   473 YQEGNH-GPHLITVPASTLDNWVRELNLWCPSFKVLVYYGSADDRKYMRYEILNQIVEYNIIVST 536

  Fly   235 YEMCI---REKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELW 296
            |.:.|   .::|:|.|....|.|.||.|.:||..|.....|.......|||:|||||||||.||.
Zfish   537 YNLAIGNSSDRSLFCKLKLEYAVFDEGHLLKNMNSLRYRHLMAINAKYRLLLTGTPLQNNLLELM 601

  Fly   297 ALLNFLLPDVFNSS-EDFDEWFNTNTCLGDDAL----ITRLHAVLKPFLLRRLKAEVEKRLKPKK 356
            :||||::|::|:|| ....:.|:..:.....:.    ||....::|||:|||:|:||.|:|..|:
Zfish   602 SLLNFIMPNMFSSSTSQIAKMFSMKSSEEQSSFERDRITHAKLIMKPFILRRVKSEVLKQLPAKE 666

  Fly   357 EMKIFVGLSKMQRDWYTKVLLKDIDVVNGAGKVEKMRLQNILMQLRKCTNHPYL----------- 410
            |...|..:|:.|::.|:.:|.|.....||    ||..|.|::|||||.:|||.|
Zfish   667 EQVEFCAMSERQQELYSALLHKLKHSSNG----EKRELTNVMMQLRKMSNHPLLHRQFYTTEKLK 727

  Fly   411 -----------FDGAEPG------------------------PPYTTDTHLVYNSGKMAILDKLL 440
                       ...|:|.                        ..|..:|.::.:|||:::|.:||
Zfish   728 AMSKLMLKEPSHRDADPALIKEDMEVLSDFELHRLCQQYSALHEYQLNTDVLLDSGKLSLLTQLL 792

  Fly   441 PKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFML 505
            ..|:|:|.||::|||.|.||||||.:.....:.|.||||.||..||...|.:||.|... |:|:|
Zfish   793 NSLKEKGDRVVLFSQFTMMLDILEVFLRHHKHRYNRLDGSTPMSDRIGLIDQFNTDQDI-FVFLL 856

  Fly   506 STRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAE 570
            |||||||||||.:|:|||::|.|.||..|.||..|.||:||.|.|:|.:||::.::|:.::...|
Zfish   857 STRAGGLGINLTSANVVILHDIDCNPYNDKQAEGRCHRVGQTKTVKVIKLISKDSIEDTMLRIGE 921

  Fly   571 VKLRLDK 577
            .||:|::
Zfish   922 RKLKLEQ 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	8/37 (22%)
		SNF2_N	131..411	CDD:278600	121/310 (39%)
		DEXDc	148..287	CDD:238005	59/142 (42%)
		HELICc	422..553	CDD:238034	67/130 (52%)
		HAND	697..796	CDD:286232
		SANT	797..838	CDD:197842
		SANT	799..838	CDD:238096
		SLIDE	853..965	CDD:286233
smarcad1b	XP_005155692.3	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920