DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and smarcad1

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001015697.1	Gene:	smarcad1 / 548414	XenbaseID:	XB-GENE-492700	Length:	1003	Species:	Xenopus tropicalis

Alignment Length:	676	Identity:	230/676 - (34%)
Similarity:	348/676 - (51%)	Gaps:	125/676 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKTDTAAVEATEENSNETTSDAAT------SSSGEK-EAEFDNKIEA---DRSRRFDFLL----- 51
            :|.||..:|     |.|:.|||.:      ||..|| |.|:..||.:   |.|....:|:
Frog   326 AKRDTRDLE-----SEESASDAGSCLDEDYSSGDEKLEEEYKTKILSFLQDASLDELYLIPHCSH 385

  Fly    52 KQTEIFTHFMTNSA-----KSPTKPKGRPKKI----KDKDKEKDVADHRHRKTEQEEDEELLAED 107
            |:.:..|.....|:     :..||..|..:.:    :...||::|......|.|:       ...
Frog   386 KKAQKITELRPFSSWESLFEKMTKSNGLSEDLIWDCQTLIKEREVVMKLMNKCEE-------ISR 443

  Fly   108 SATKEIFRFDASPAYIKSGE----------------MRDYQIRGLNWMISLYENGINGILADEMG 156
            :.||::.:.      .:.||                ::.||..||||:..|:::.:|.|||||||
Frog   444 TLTKQVTQL------TEDGECGWNIEQPSIMSENLVLKPYQKIGLNWLALLHKHKVNMILADEMG 502

  Fly   157 LGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRD 221
            ||||:|.|:.|.:| :....:|||:|:||.||:.||:.||.:||||:..:...|.|:.|.....|
Frog   503 LGKTVQAIAFLAHL-YVTGDSGPHLVVVPASTMDNWIREFNQWCPSMNILLYYGSQEERKHLRYD 566

  Fly   222 VL-MPGEWDVCVTSYEMCI---REKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLL 282
            :| ...|::|.||:|...|   .::|:|::....:.|.||.|.:||..:...:.|......:|||
Frog   567 ILNKVVEFNVIVTTYNCAISSAEDRSLFRRLKLNFAVFDEGHMLKNMSAIRYQHLMTLNARSRLL 631

  Fly   283 ITGTPLQNNLHELWALLNFLLPDVFNSS-EDFDEWFNTNTCLGDDALITR----LHA--VLKPFL 340
            :||||:||||.||.:||||::|.:|:|| .:....|::.....|:..|..    .||  ::|||:
Frog   632 LTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIKRLFSSKAKSTDEQTIFEKERIAHAKQIMKPFI 696

  Fly   341 LRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKV---LLKDIDVVNGAGKVEKMRLQNILMQLR 402
            |||:|:||.|:|.||::...|..:||.|...|:.:   |.|.||...     :...|.|::|.||
Frog   697 LRRVKSEVLKQLPPKQDKIKFCQMSKKQEQLYSDLLNKLKKSIDATE-----KNSELCNVMMHLR 756

  Fly   403 KCTNHP------YLFD----------------GAEPG------------------------PPYT 421
            |..|||      |..|                .|.|.                        ..|.
Frog   757 KMANHPLLHRQYYTADRLRTMSKLMLKEPTHCDANPDLIFEDMEVMTDFELHRLCNEFTTLSQYK 821

  Fly   422 TDTHLVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDR 486
            .:..|:.:|||..||:|||..::::|.||::|||.|.||||:|.:.....:.|.||||:|...:|
Frog   822 LEKELILDSGKFNILEKLLSDIKKKGDRVVLFSQFTMMLDIIEVFLRHHQHRYVRLDGKTQISER 886

  Fly   487 NRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVR 551
            ...|.|||.|... |:|:|||:||||||||.:|::||::|.|.||..|.||.||.||:||.|:|:
Frog   887 IHLIDEFNTDMDI-FIFLLSTKAGGLGINLTSANIVILHDIDCNPYNDKQAEDRCHRVGQTKEVK 950

  Fly   552 VFRLITESTVEEKIVERAEVKLRLDK 577
            |.:||.:.|:||.:::.::.||||::
Frog   951 VIKLIGKGTIEESMLKISQQKLRLEQ 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	12/50 (24%)
		SNF2_N	131..411	CDD:278600	117/299 (39%)
		DEXDc	148..287	CDD:238005	57/142 (40%)
		HELICc	422..553	CDD:238034	64/130 (49%)
		HAND	697..796	CDD:286232
		SANT	797..838	CDD:197842
		SANT	799..838	CDD:238096
		SLIDE	853..965	CDD:286233
smarcad1	NP_001015697.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..130
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..235
		CUE	223..259	CDD:270465
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..351		9/29 (31%)
		PLN03142	464..>975	CDD:215601	194/517 (38%)
		DEXHc_SMARCAD1	474..656	CDD:350756	77/182 (42%)
		DEGH box	605..608		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920