DRSC/TRiP Functional Genomics Resources

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Protein Alignment Iswi and Smarcal1

DIOPT Version :10

Sequence 1:NP_523719.1 Gene:Iswi / 36390 FlyBaseID:FBgn0011604 Length:1027 Species:Drosophila melanogaster
Sequence 2:NP_061287.2 Gene:Smarcal1 / 54380 MGIID:1859183 Length:910 Species:Mus musculus


Alignment Length:678 Identity:159/678 - (23%)
Similarity:274/678 - (40%) Gaps:164/678 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 KDKEKDVADHRHRKTE--QEEDEELLAEDSATKEIFRFDASPAYIK------------------- 124
            |..|....|.:.||..  .||..:|:|.....|:: :.|..|..:.                   
Mouse   317 KQMESRSYDIKTRKWSFLLEEHNKLIARSRELKQV-QLDPLPKTVTLAFASQLEKTSPKLKADVP 380

  Fly   125 ----SG-------EMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAG 178
                ||       .:..:|..|:::.||  :.| ..:|||:||||||:|.|.:..    |..:..
Mouse   381 EADLSGVDAKLVSSLMPFQREGVSFAIS--KRG-RLLLADDMGLGKTVQAICIAA----FYRKEW 438

  Fly   179 PHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWD-----VCVTSYE-M 237
            |.:|:||.|....|...|.:|.|||....:            :|::.|:..     |.:.|:: :
Mouse   439 PLLVVVPSSVRFTWEQAFLRWLPSLSPENI------------NVVVTGKGRLTAGLVNIVSFDLL 491

  Fly   238 CIREKSVFKKFNWRYLVIDEAHRIKNEK-SKLSEILREFKTANR-LLITGTPLQNNLHELWALLN 300
            |..|:.:  |..::.::|||:|.:||.| ::....:...|.|.| :|::|||..:...||:..:.
Mouse   492 CKLERQL--KTPFKVVIIDESHFLKNIKTARCRAAVPILKVAKRVILLSGTPAMSRPAELYTQII 554

  Fly   301 FLLPDVFNSSEDFD---------EW---FNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLK 353
            .:.|..|.....|.         .|   ::.::.||:..|:..     :..:|||||::|..:| 
Mouse   555 AVKPTFFPQFHAFGLRYCDAKRLPWGWDYSGSSNLGELKLLLE-----EAIMLRRLKSDVLSQL- 613

  Fly   354 PKKEMKIFV-------GLSKMQRDWYTKVLLKDIDVVNGAGKVEKMRLQNILMQLRKCTNHPYLF 411
            |.|:.|:.|       ..:|...|...|.:.||        |.::.:.:.:|:...:.       
Mouse   614 PAKQRKMVVVNPGRISSRAKAALDAAAKEMTKD--------KTKQQQKEALLVFFNRT------- 663

  Fly   412 DGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCR 476
              ||...|              .:::.:|..|.....:.|:|:....:||.:......:|..:.|
Mouse   664 --AEAKIP--------------CVVEYILDLLDSGREKFLVFAHHKVILDAVAKELERKNVQHIR 712

  Fly   477 LDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRA 541
            :||.||..||..|.|.|.: :....:.:||..|..:|:..:|||:|:..:..|||.:.:||.||.
Mouse   713 IDGSTPSADREAQCQRFQL-SKGHTVALLSITAANMGLTFSTADLVVFAELFWNPGVLIQAEDRV 776

  Fly   542 HRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGA 606
            |||||...|.:..|:.:.|.::.:....:.|:::         |.:...::.|..||        
Mouse   777 HRIGQTNSVSIHYLVAKGTADDYLWPLIQEKIKV---------LGEAGLSETNFSEM-------- 824

  Fly   607 NQVFSSKETDITDEDIDVILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFE--- 668
                 ::.||...:|            .:||...|...:|    |..|.|......:...||   
Mouse   825 -----TEATDYVHKD------------PKQKTIYDLFQQS----FEDDGNDMEFLEAAESFELGS 868

  Fly   669 --GEDWREKQKLNALGNWIE--PPKRER 692
              |......|.|..|.:..|  |||:.|
Mouse   869 TSGTSGNISQDLGDLLDEDEGSPPKKSR 896

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IswiNP_523719.1 PLN03142 46..967 CDD:215601 159/678 (23%)
Smarcal1NP_061287.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..198
Mediates interaction with RPA2. /evidence=ECO:0000250 2..29
Mediates interaction with RPA2. /evidence=ECO:0000250|UniProtKB:Q9NZC9 5..29
HARP 214..268 CDD:462166
HepA <329..809 CDD:440319 131/539 (24%)
DEXHc_HARP_SMARCAL1 395..604 CDD:350768 59/234 (25%)
DESH box 508..511 2/2 (100%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9NZC9 603..620 8/17 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 868..896 8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

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