DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and smarca5

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001007993.1	Gene:	smarca5 / 493355	XenbaseID:	XB-GENE-494817	Length:	1049	Species:	Xenopus tropicalis

Alignment Length:	1034	Identity:	740/1034 - (71%)
Similarity:	856/1034 - (82%)	Gaps:	38/1034 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DTAAVEATE--ENSNETTSDAATSS--SGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHFMTNSA 65
            |....||.|  |..||...|:...|  ..|.:..::.|.:.|||.||::||||||:|.||:..:|
Frog    42 DAVKEEAMEDYELDNEDDDDSLNKSKEGNEMDPAYEEKRKTDRSNRFEYLLKQTEVFAHFIQPAA 106

  Fly    66 -KSPTKP----KGRPKKIKDKDKE-KDVADHRHRKTEQEEDEELLAEDSATKEI-FRFDASPAYI 123
             |:||.|    .|||:..||:.:: ..:.|:|||:||||||||||.|.|.|..: .||:.||:|:
Frog   107 QKTPTSPLKMKPGRPRLKKDEKQDLLSMGDYRHRRTEQEEDEELLTESSKTTNVCTRFEDSPSYV 171

  Fly   124 KSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKST 188
            |.|.:||||:|||||:||||||||||||||||||||||||||||||:||:::..|||:|:|||||
Frog   172 KGGTLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRSIPGPHMVLVPKST 236

  Fly   189 LQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRYL 253
            |.||:.|||:|.|||.|:|||||:|.|..|:||||:|||||||||||||.|:|||||||||||||
Frog   237 LHNWMAEFKRWVPSLCAICLIGDKDHRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYL 301

  Fly   254 VIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFN 318
            ||||||||||||||||||:|||||.||||:||||||||||||||||||||||||||:||||.||:
Frog   302 VIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFD 366

  Fly   319 TNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVV 383
            ||.||||..|:.|||.|||||||||:||:|||.|.||||:||:||||||||:||||:|:||||::
Frog   367 TNNCLGDQKLVERLHMVLKPFLLRRIKADVEKSLPPKKEIKIYVGLSKMQREWYTKILMKDIDIL 431

  Fly   384 NGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGS 448
            |.:||.:||||.|||||||||.||||||||||||||||||.|||.|||||.:||||||:|:||||
Frog   432 NSSGKTDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDMHLVTNSGKMVVLDKLLPRLKEQGS 496

  Fly   449 RVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLG 513
            ||||||||||:||||||||.||||.|||||||||||:|...|..:|...|:||:|||||||||||
Frog   497 RVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHEERQDSIIAYNAPGSSKFIFMLSTRAGGLG 561

  Fly   514 INLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKM 578
            |||||||||||||||||||:|||||||||||||.|.|||||.||::||||:||||||:|||||.:
Frog   562 INLATADVVIIYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRYITDNTVEERIVERAEMKLRLDSI 626

  Fly   579 VIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDVILERGEAKTAEQKAALDSL 643
            |||.|||||...|:|.|||||.:||.||..||:||:::||:|||:.||||||.||||....|.::
Frog   627 VIQQGRLVDQNLNKLGKDEMLQMIRHGATHVFASKDSEITEEDINAILERGEKKTAEMNEKLSNM 691

  Fly   644 GESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPKRERKANYAVDAYFREALRV 708
            ||||||.||:|..     ||||.|||||:|||||: |...|||||||||||||||||||||||||
Frog   692 GESSLRNFTVDNE-----SSVYNFEGEDYREKQKM-AFTEWIEPPKRERKANYAVDAYFREALRV 750

  Fly   709 SEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKVPKNTELGSDATKVQREEQR 773
            ||||.||||||||||.|||||||||||||||::||.|:|||:|||||:|.:| .:|.:.|:|||.
Frog   751 SEPKVPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRNPDL-PNAAQAQKEEQL 814

  Fly   774 KIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNIAKDVEGKTPEEVIEY 838
            ||||||||.:||::|||.||:||||.|.|||||||||||||:|||||:|||::||||||||||||
Frog   815 KIDEAEPLNDEELEEKEKLLTQGFTNWNKRDFNQFIKANEKWGRDDIENIAREVEGKTPEEVIEY 879

  Fly   839 NAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFHQLRLQYGNNKGKNYT 903
            :|||||||.||||||:||.||||||.:||||:|||||||.|:.||:|||||||:.||.|||||||
Frog   880 SAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDTKIGRYKAPFHQLRISYGTNKGKNYT 944

  Fly   904 EIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQRRCNTLITLIERENI 968
            |.|||||:||||||||||||||:|||..||.|||||||||:|||||:|||||||||||||||||:
Frog   945 EEEDRFLICMLHKLGFDKENVYDELRQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENL 1009

  Fly   969 ELEEKERAEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQKRKSEVVATSSNSKKKKK 1027
            ||||||:|||||:.|:                    |.::||||.:........|||.|
Frog  1010 ELEEKEKAEKKKRGPR--------------------PSSAQKRKVDGTPDGRGRKKKLK 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	17/37 (46%)
		SNF2_N	131..411	CDD:278600	225/279 (81%)
		DEXDc	148..287	CDD:238005	112/138 (81%)
		HELICc	422..553	CDD:238034	106/130 (82%)
		HAND	697..796	CDD:286232	74/98 (76%)
		SANT	797..838	CDD:197842	34/40 (85%)
		SANT	799..838	CDD:238096	32/38 (84%)
		SLIDE	853..965	CDD:286233	91/111 (82%)
smarca5	NP_001007993.1	PLN03142	7..1004	CDD:215601	713/968 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	477	1.000	Domainoid score	I429
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1517	1.000	Inparanoid score	I99
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144251at33208
OrthoFinder	1	1.000	-	-		FOG0001113
OrthoInspector	1	1.000	-	-		otm48320
Panther	1	1.100	-	-	O	PTHR10799
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1240
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160