DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and dom

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001286676.1	Gene:	dom / 45655	FlyBaseID:	FBgn0020306	Length:	3233	Species:	Drosophila melanogaster

Alignment Length:	1724	Identity:	372/1724 - (21%)
Similarity:	560/1724 - (32%)	Gaps:	772/1724 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KTDT---------AAVEATEENSNETTSDAATSSSGEKEAEFDNK-----IEADRSRRFDFLLKQ 53
            ||:|         .|.||::::.|      ..|...|.|.|.|:|     :|||.....:.||.:
  Fly   761 KTETPDDSDDSEFEAKEASDDDEN------TISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAK 819

  Fly    54 TEIFTHFMTNSAKSPTKPKGRPKKIKDKDKEKDVAD----------HRHRKTEQEED-------- 100
            .:         ::.|..||.|  |:..:|.|.|..|          .....||.|||
  Fly   820 YK---------SEQPPSPKRR--KLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDT 873

  Fly   101 ------------EELLAEDSAT---------------KEIFRFDAS------------------- 119
                        :.|:|:..||               |:....||:
  Fly   874 DMEEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVV 938

  Fly   120 ---PAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHI 181
               |..:|. .:|:||..||:|::::.|..:|||||||||||||:|||:||.:|...|...|||:
  Fly   939 TPVPFLLKH-SLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHL 1002

  Fly   182 VIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFK 246
            ::||.|.:.||..|||||||..:.:...|.|..|.........|..:.||:|||::.::::..|:
  Fly  1003 IVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNAFHVCITSYKLVVQDQQSFR 1067

  Fly   247 KFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSE 311
            :..|:||::|||..|||.||:..::|..|.|..|||:|||||||:|.|||:|::||:|.||:|..
  Fly  1068 RKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHR 1132

  Fly   312 DFDEWFNTNTCLG--------DDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQ 368
            :|.||| :|...|        ::.||||||.|::||||||||.||||::..|.|..|...||..|
  Fly  1133 EFKEWF-SNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQ 1196

  Fly   369 RDWYTKVLLKDIDVVNGAGKVEKMR------LQNILMQLRKCTNHPYLFD--------------- 412
            |..|.       |.::.|...|.::      :.|:||||||..|||.:|:
  Fly  1197 RYLYE-------DFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITF 1254

  Fly   413 ----------------------------------------------------------------- 412

  Fly  1255 HTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRC 1319

  Fly   413 ---------------------------GAEP---------------------------------- 416
                                       ||.|
  Fly  1320 PNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNM 1384

  Fly   417 --------------------------------------------------------GPPY----- 420
                                                                    |.|:
  Fly  1385 ALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTP 1449

  Fly   421 ---------------------------TTDT---------------------------------- 424
                                       ||.|
  Fly  1450 ATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANG 1514

  Fly   425 ----------------------------------------------------------------- 424

  Fly  1515 KTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRS 1579

  Fly   425 ---------------------------HLV----------------------------------- 427
                                       ||:
  Fly  1580 LKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQN 1644

  Fly   428 ---------------------------------------------YNSGKMAILDKLLPKLQEQG 447
                                                         |:.||:..:|:||.:|:..|
  Fly  1645 LSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNG 1709

  Fly   448 SRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGL 512
            .|||||:|||:|||:||.:.::..:.|.||||.|..|.|...::.||.|... |.|:||||:||:
  Fly  1710 HRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFNGDKRI-FCFILSTRSGGV 1773

  Fly   513 GINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDK 577
            ||||..||.||.|||||||.||.||.||.|||||.:.|.::||::|.|:|..|:::|..|..|..
  Fly  1774 GINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSD 1838

  Fly   578 MVIQGGR----------------LVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDED----- 621
            |.|:||.                :..:..::.::::..|..|..|....|...:.:.:.:
  Fly  1839 MAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQEKSENKDRIVATTTLSDTPSTVVETEKQSLR 1903

  Fly   622 -IDVILERGE-------AKTAEQKAALDSLGE--SSLRTFTMDTNGEAG---------------- 660
             .:..|...|       .|||:.:.|.| |.|  .::...|.|.|.|.|
  Fly  1904 AFEHALAAAEDEQDVQATKTAKAEVAAD-LAEFDENIPIATEDPNAEGGPQVELSKADLEMQNLV 1967

  Fly   661 --TSSVYQF-------EGEDWREKQKLNALGNWIEPPKRERKANYAVDAYFREALRVSEPKAPK- 715
              .|.:.::       .|..|..:| |.|....:|..|||.:||.....:..|.|...|.:|.:
  Fly  1968 KQLSPIERYAMRFVEETGAAWTAEQ-LRAAEAELEAQKREWEANRLAAMHKEEELLKQETEAEEM 2031

  Fly   716 --------------------------APRPPK---QPIVQDFQFFPPRLFEL-----LDQEIYYF 746
                                      .|.||:   ..|..|:..  ..::||     .|....|.
  Fly  2032 LTYSRKDSSNQVWISRNTMEQMPMWCPPTPPQDNDNDIYIDYSL--SFMYELEPIAETDLPPVYV 2094

  Fly   747 RKTVGYKVPKNTELGSDATKVQREEQRKIDEAEPL------TEEEIQEKENLLSQGFTAWTKRDF 805
            ||.  :| ...|:.|.|.::...:.:|:.:...|.      |.:..:.:..|.||.|....|.:.
  Fly  2095 RKE--HK-RSRTDAGYDGSRRPNKMRREDNYVPPRSLFDRPTPQLARLRRELKSQRFRGSFKPNM 2156

  Fly   806 NQFIKANEKYGRDDIDNIAKDVEGK---TPEEVIEYNAVF------------------------- 842
                         .|..:...:..|   .||.:.|: .||
  Fly  2157 -------------PIPGLKPQLPTKPLTEPEAMAEW-CVFEDMAILHVLVNLQGLPCSLMLLSPG 2207

  Fly   843 ----WERCTEL------------QDIERIMGQIE-RGEGKI----QRRLSIKKALDQKMSRYRAP 886
                |:..:|:            |...|....|: |.|||:    :::..:|..|  :....::|
  Fly  2208 QTPNWDLVSEMVNFCSKTYRSARQCRWRYETHIQPREEGKVVESPKKQKKLKPTL--RTEYLKSP 2270

  Fly   887 FHQLR---LQYGNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAI--RASP---QFRFDWF 943
            ...||   |...:|....|..:..||                :.::.|.  :|.|   ||
  Fly  2271 LRYLRTTQLYVSDNNASFYKTMRSRF----------------DSIKTAYLKKAPPPKRQF----- 2314

  Fly   944 IKSRTALELQRRCNTLITL--------IERENI------ELEEKERAEKKKKAPKG-SVSAGSGS 993
              |..:|...:....|...        :..:||      ::.||:|.::..:.|.| .|......
  Fly  2315 --SAPSLMNPKHMEVLQEFGILNYDQPVSPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQMQQ 2377

  Fly   994 ASSNTPAPAPQPKASQKRKSEVVATSSNSKKKKK 1027
            .|.....|||.|...|::..:||......:::::
  Fly  2378 QSQQQQQPAPPPLPQQQQPQQVVQQVQQQQQQQQ 2411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	10/41 (24%)
		SNF2_N	131..411	CDD:278600	132/293 (45%)
		DEXDc	148..287	CDD:238005	64/138 (46%)
		HELICc	422..553	CDD:238034	71/336 (21%)
		HAND	697..796	CDD:286232	24/139 (17%)
		SANT	797..838	CDD:197842	6/43 (14%)
		SANT	799..838	CDD:238096	5/41 (12%)
		SLIDE	853..965	CDD:286233	24/132 (18%)
dom	NP_001286676.1	HSA	543..614	CDD:214727
		ASF1_hist_chap	<674..831	CDD:304562	21/84 (25%)
		FAM176	<824..>868	CDD:291517	14/45 (31%)
		SNF2_N	952..1238	CDD:278600	132/293 (45%)
		DEXDc	969..1108	CDD:238005	64/138 (46%)
		Helicase_C	1692..1806	CDD:278689	62/114 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467155
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930