DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and CG10445

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001246974.1	Gene:	CG10445 / 40938	FlyBaseID:	FBgn0037531	Length:	945	Species:	Drosophila melanogaster

Alignment Length:	900	Identity:	183/900 - (20%)
Similarity:	308/900 - (34%)	Gaps:	365/900 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EENSNETTS-----------DAATSSSGE-------KEAEFDNKIEADRSRRFDFLLKQTEIFTH 59
            |||::||..           :|...:.||       :|.:.:.||| |.|.    |:..||
  Fly    91 EENASETKELCDLKLHLEKLNARLEALGEFLDTLRLREDQQEIKIE-DNSE----LVDHTE---- 146

  Fly    60 FMTNSAKSPTKPKGRPK---------KIKDKDKEKDVADHRHR-------KTEQEEDEELLAEDS 108
                          :||         :.:.|........::|:       ||..|..:...|.|.
  Fly   147 --------------QPKWSNLYSGLNRYRQKANHTAAQFYQHKSNIIDSLKTLYEPIQPRPAIDD 197

  Fly   109 ATKEIFRFDASPAYIKSGEMRDYQIRGLNWMISLYENGIN-GILADEMGLGKTLQTISLLGYLKH 172
            ..|:       ||.:.. .:..:|...|.||.......|: |||||:|||||||..|:|:...:.
  Fly   198 LEKQ-------PALLLV-RLLKHQQSCLKWMQFRERQKISGGILADDMGLGKTLSMIALILASEE 254

  Fly   173 FKNQAGPHIVIVPKSTLQNWVNEFKK-WCPSLRAVCLIGDQD----------------------- 213
            .||:....   ..|:....|..||.: :|..:|.:.:..|::
  Fly   255 TKNRKREE---KKKALTLKWTQEFNRVYCKEIRKISMFDDEEESGKEEEQYEPPEKRTCHVKTKK 316

  Fly   214 ----------------------------------------------------TRNTF-------- 218
                                                                :.||.
  Fly   317 INQFRILDDDDNDAGDKAVVEDEQKDLLAKTPEPEVFSSDEEEEHLSNGRYPSANTLVVCPMSVM 381

  Fly   219 ---------------IRDVLMPG------------EWDVCVTSYEMCIREKSVFKKFN------- 249
                           ||.:...|            .:|:.:|||.:.:.|   .|::.
  Fly   382 CQWAHEVASKVAQNAIRVLTFHGPNRHEIGIEAFRSYDLVITSYNLVVNE---LKRYGNTSPLFA 443

  Fly   250 --WRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFL-LPDVFNSSE 311
              |..:::||||.|:|.|:.....:.:.:......:||||:||...:::|||.|: :|:.    :
  Fly   444 VYWNRVILDEAHIIRNSKTNCCNSVCQLRAHCHWALTGTPVQNRGVDVFALLRFVNVPNF----Q 504

  Fly   312 DFDEW-FNTN-TCLGDDALITRLHAVLKPFLLRRLKAEVE--------KRLK--------PKKEM 358
            |..:| .|.| :.||.    .||:.::||.:|||.|.:::        ..||        .|.||
  Fly   505 DLQQWKKNLNESMLGH----RRLNFIIKPLMLRRTKQKLQASGDMPALPSLKIELICVQLSKTEM 565

  Fly   359 KIFVGLSKMQRDWYTKVLLK------DIDV-------------------------------VNGA 386
            .::..||.:.:..:|:.||:      |::.                               .|..
  Fly   566 AVYQILSAISKKIFTQFLLQREKGNSDLNYYSLERTPQFIAGHMSDERYNEIYERFLKSLGYNPG 630

  Fly   387 GKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLV------------------------ 427
            .|:..:.:..:|::||:...||.|..|...|.....|...|
  Fly   631 EKILGIYILVLLLRLRQFCCHPGLMIGMLRGALTAEDVQNVKVDASDVEGQLKMDVLAELDKFDE 695

  Fly   428 -----------------------------------YNSG-------------------------- 431
                                               ::||
  Fly   696 TDSEDDCCDEEDSTRRDGNFKLEVIKDEIKEENVPWDSGDDLPTASSFEDQLDSARALKLLNPQN 760

  Fly   432 ------------KMAILDKLLPKLQEQGSRVLIFSQMTRMLDI----LEDYCHWRNYNYCRLDGQ 480
                        || ::|||...|.....::::.||....|.|    |:| ..|...::   :||
  Fly   761 PIFQFIRPSAKLKM-VIDKLEELLTGTNDKIIVTSQWVSYLAIVRKRLQD-LSWETLDF---NGQ 820

  Fly   481 TPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIG 545
            ...::|...:::||.:|..:.| :||..|||:|:||..|:.::|.|..||||::.||.||.:|.|
  Fly   821 LTAKEREIVLRDFNANNEKRVL-LLSLTAGGVGLNLNVANHMLIVDLHWNPQLERQAQDRIYRYG 884

  Fly   546 QKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVI--QGGRLVDNRSNQLNKDEM 598
            |.|...::|.:.:.|||::|....:.||.:.|:|:  :||.:.......||..|:
  Fly   885 QTKPTFIYRYMCQDTVEQRIKSLQDCKLEIAKVVLPEEGGEVTKCVGGGLNLAEL 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	10/43 (23%)
		SNF2_N	131..411	CDD:278600	90/456 (20%)
		DEXDc	148..287	CDD:238005	44/259 (17%)
		HELICc	422..553	CDD:238034	47/231 (20%)
		HAND	697..796	CDD:286232
		SANT	797..838	CDD:197842
		SANT	799..838	CDD:238096
		SLIDE	853..965	CDD:286233
CG10445	NP_001246974.1	HepA	<90..945	CDD:223627	183/899 (20%)
CG10445	NP_001246974.1	DEAD-like_helicase_N	209..534	CDD:421690	69/338 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467127
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840