DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and Mi-2

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster

Alignment Length:	1077	Identity:	310/1077 - (28%)
Similarity:	477/1077 - (44%)	Gaps:	212/1077 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 TNSAKSPTKPKGRPKKIKDKDKEKDVADHRHRKTEQEEDEELLAEDSATKEIFRFDASPAYIKSG 126
            |..::|....|||..|:|.:|.|.....|.....|:...:        .|:  :::..||:::..
  Fly   673 TTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTD--------LKK--KYEDQPAFLEGT 727

  Fly   127 --EMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTL 189
              ::..|||.|:||:...:..||:.|||||||||||:||::.|..|....:..||.:|.||.|||
  Fly   728 GMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTL 792

  Fly   190 QNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGE------------------WDVCVTSYE 236
            .||..||:.|.|....:..|||:|:| ..||:..:..|                  ::|.:||||
  Fly   793 VNWEREFELWAPDFYCITYIGDKDSR-AVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYE 856

  Fly   237 MCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNF 301
            :...:.:.....:|..||:|||||:|:.:||...||..:..|.:||:|||||||||.||:.||||
  Fly   857 LISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNF 921

  Fly   302 LLPDVFNSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSK 366
            |..|.||..:.|...|   ..:..:..:.|||.:|.|.:|||||.:|.|.:..|.|..:.|.||.
  Fly   922 LSRDKFNDLQAFQGEF---ADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSA 983

  Fly   367 MQRDWYTKVLLKDIDVVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGA------EPGPPYTTDTH 425
            ||:.:|..:|.|:.:.:|.........|.||:|.|:||.||||||..|      ..|..|..::
  Fly   984 MQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINS- 1047

  Fly   426 LVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQI 490
            |...:||:.:|.|:|.:|:.|..|||||||||:|||||||:.....|.|.|:||......|...|
  Fly  1048 LTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAI 1112

  Fly   491 QEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRL 555
            ..||...:.:|:|:||||||||||||||||.||||||||||..|:||..|||||||..:|.::|.
  Fly  1113 DRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRF 1177

  Fly   556 ITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETD---- 616
            :|.::|||::.:.|:.|:.|..:|::.|  :..:.....|.|:.:|:|||...:|  ||.|
  Fly  1178 VTRNSVEERVTQVAKRKMMLTHLVVRPG--MGGKGANFTKQELDDILRFGTEDLF--KEDDKEEA 1238

  Fly   617 --ITDEDIDVILERGEAKTAEQKA-ALDSLGESSLRTFTMDTNGEAGTSSVYQFEGED-----W- 672
              ..|:.:..:|:|......|::: |.:.|....:.::......|...:.:.:.:.|:     |
  Fly  1239 IHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYWV 1303

  Fly   673 -----REKQKLNALGNWIEPPKRERK-ANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFF 731
                 ..:|....:|..:...||.|| .||            ::.....|.........||
  Fly  1304 KLLRHHYEQHQEDVGRSLGKGKRVRKQVNY------------TDGGVVAADTTRDDSNWQD---- 1352

  Fly   732 PPRLFELLDQEIYYFRKTVGYKVPKNTELGSDATKVQREEQRKIDEAE--PLTEEEIQEKENLLS 794
                    :...|....:.|.......:...|....:|:.:|:::..:  ||.....:...|:..
  Fly  1353 --------NGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEV 1409

  Fly   795 QGFTAWTKRDFNQFIKANEKYGRDDIDN-----IAKDVEGKTPEEVIEYNAVFWERCTE------ 848
            .||.|   |....|:.|..:||....|.     :.:|:.||:......|.::|.....|
  Fly  1410 LGFNA---RQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNA 1471

  Fly   849 ------------------------------LQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRY 883
                                          :|:.|.|.|.....|..::....::.||.|.::..
  Fly  1472 ETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAAL 1536

  Fly   884 RAPFHQLRLQYGNNKGKNYT--------------------EIEDRFLVCMLHKLGFDKENVYEEL 928
            .||      ..|.|..|:.|                    :.||:           ||::..|
  Fly  1537 EAP------PTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDK-----------DKDSEKE-- 1582

  Fly   929 RAAIRASPQFRFDWFIKSRTALELQRRCNTLITLIERENIELEEKERAEKKKKAP---------- 983
                            |.:|:.|...        :::|....|:|:..:.|::.|
  Fly  1583 ----------------KDKTSAEKSE--------VKQEQEAEEDKKPGDVKQENPVEEAAGDTKP 1623

  Fly   984 -----KGSVSAGSGSASSNTPAPAPQPKASQKRKSEV 1015
                 |..|:.......:..|....:||..:|.|.:|
  Fly  1624 SDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKV 1660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	1/4 (25%)
		SNF2_N	131..411	CDD:278600	121/297 (41%)
		DEXDc	148..287	CDD:238005	60/156 (38%)
		HELICc	422..553	CDD:238034	72/130 (55%)
		HAND	697..796	CDD:286232	11/100 (11%)
		SANT	797..838	CDD:197842	11/45 (24%)
		SANT	799..838	CDD:238096	10/43 (23%)
		SLIDE	853..965	CDD:286233	21/131 (16%)
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CHROMO	490..558	CDD:237991
		CHROMO	615..667	CDD:214605
		SNF2_N	734..1028	CDD:278600	121/297 (41%)
		DEXDc	751..907	CDD:238005	60/156 (38%)
		Helicase_C	1053..1167	CDD:278689	67/113 (59%)
		DUF1087	<1292..1337	CDD:283996	10/56 (18%)
		DUF1086	1380..1517	CDD:283992	24/139 (17%)
		CHDCT2	1756..1927	CDD:285336
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467158
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840