DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and brm

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster

Alignment Length:	1214	Identity:	349/1214 - (28%)
Similarity:	520/1214 - (42%)	Gaps:	381/1214 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EKEAEFDNKIEADRSRRFDFLLKQTEIFTHFMTNSAKSPTKPKGRPKKIKDK------------- 81
            |.|..:...|:..:.:|..|||.||:.:...:|...|.....:.:.|:.:.|
  Fly   574 EDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSG 638

  Fly    82 -----DKEKDVAD-----------------------HRHR------------------------- 93
                 |:...|||                       |.||
  Fly   639 EYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHK 703

  Fly    94 -KTEQE---------------EDEELLAEDSATK-----EIFRFDASPAY--------------- 122
             |.|::               .||:  |:|..||     :.:|.:....|
  Fly   704 PKVEEQPTATEDATDKAQATGNDED--AKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQAS 766

  Fly   123 -IKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPK 186
             :.:|.:::|||:||.|::|||.|.:|||||||||||||:|||||:.||...|...||:::|||.
  Fly   767 IMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPL 831

  Fly   187 STLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWR 251
            |||.|||.||:||.|::..|...|....|. .:::.:...:::|.:|:||..|::|:|..|..|:
  Fly   832 STLPNWVLEFEKWAPAVGVVSYKGSPQGRR-LLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWK 895

  Fly   252 YLVIDEAHRIKNEKSKLSEILR-EFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDE 315
            |::|||.||:||...||:::|. .:....|||:|||||||.|.|||||||||||.:|.|...|::
  Fly   896 YMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQ 960

  Fly   316 WFNT--------------NTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSK 366
            |||.              .|.|    :|.|||.||:||||||||.|||.:|..|.|..|...:|.
  Fly   961 WFNAPFATTGEKVELNEEETIL----IIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSA 1021

  Fly   367 MQRDWYTKVLLKDIDVVNGA-----GKVEKMRLQNILMQLRKCTNHPYLFD-------------G 413
            :||..|..:..|.:.:.:|:     ||.....|.|.::||||..|||::|.             |
  Fly  1022 LQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHG 1086

  Fly   414 AEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLD 478
            ...||    |.:.|  |||..:||::||||:....|||:|.|||:.:.|:|||..||.:.|.|||
  Fly  1087 VVSGP----DLYRV--SGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLD 1145

  Fly   479 GQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHR 543
            |.|..|||...:::||...|..|:|:|||||||||:||.|||.|:|:||||||..||||.|||||
  Fly  1146 GTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHR 1210

  Fly   544 IGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEML-NIIRFGAN 607
            |||:.:|||.||:|.::|||:|:..|..||.:|:.|||.| :.|.:|....:.:.| .|:....|
  Fly  1211 IGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAG-MFDQKSTGSERQQFLQTILHQDDN 1274

  Fly   608 QVFSSKETDITDED-IDVILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGED 671
            :  ..:|.::.|:: |::::.|.|.:....|                            :.:.|.
  Fly  1275 E--EEEENEVPDDEMINMMIARSEEEIEIFK----------------------------RMDAER 1309

  Fly   672 WREKQKLNALGNWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLF 736
            .:|.::::        |.|||              .:.|.:.|       ..:.:|
  Fly  1310 KKEDEEIH--------PGRER--------------LIDESELP-------DWLTKD--------- 1336

  Fly   737 ELLDQEIYYFRKTVGYKVPKNTELGSDATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWT 801
               |.|:..|.    |:..::|.||..:     .:::::|..:.|||:|              |.
  Fly  1337 ---DDEVERFH----YQYDEDTILGRGS-----RQRKEVDYTDSLTEKE--------------WL 1375

  Fly   802 KR--DFNQF--------------IKANEKYGRDD------------IDNIAKDVEGKTPEEVIEY 838
            |.  |..:|              .:.|.|...||            :|..:|....|....||::
  Fly  1376 KAIDDGAEFDEEEEEDDSKRKRRKRKNRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMSAVIKH 1440

  Fly   839 N---AVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFHQLRLQYGNNKGK 900
            |   ....|...:|...:|:....|    .|:|.:.|||.|.             |::  :.|..
  Fly  1441 NQDGRTLSEPFMKLPSRQRLPDYYE----IIKRPVDIKKILQ-------------RIE--DCKYA 1486

  Fly   901 NYTEIEDRFL-VCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQRRCNTLITLIE 964
            :..|:|..|: :|       ....:|.|     .||                          ||.
  Fly  1487 DLNELEKDFMQLC-------QNAQIYNE-----EAS--------------------------LIY 1513

  Fly   965 RENIELEE---KERAEKKKKAPKGSVSAG--SGSASSN--------------------------- 997
            .::|.|::   ..|......|...:|:||  :|.|..|
  Fly  1514 LDSIALQKVFVGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDEEIATTS 1578

  Fly   998 --------------TPAPAPQPKASQKRKSEVVATSSNSKKKKK 1027
                          ..|||...::|....|....||....::|:
  Fly  1579 AAAVKMKLKLNKSLASAPATPTQSSSNVSSGAATTSKKQTRRKR 1622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	10/36 (28%)
		SNF2_N	131..411	CDD:278600	138/299 (46%)
		DEXDc	148..287	CDD:238005	65/139 (47%)
		HELICc	422..553	CDD:238034	74/130 (57%)
		HAND	697..796	CDD:286232	15/98 (15%)
		SANT	797..838	CDD:197842	13/68 (19%)
		SANT	799..838	CDD:238096	13/66 (20%)
		SLIDE	853..965	CDD:286233	20/112 (18%)
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903
		HSA	501..573	CDD:214727
		BRK	649..693	CDD:197800	6/43 (14%)
		PHA02934	687..>824	CDD:165245	42/138 (30%)
		SNF2_N	776..1071	CDD:278600	138/299 (46%)
		DEXDc	793..932	CDD:238005	65/139 (47%)
		Helicase_C	1097..1212	CDD:278689	67/114 (59%)
		SnAC	1304..1375	CDD:291293	21/134 (16%)
		Bromo_SNF2L2	1425..1530	CDD:99947	30/161 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467156
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10799
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940