Protein Alignment Iswi and Ercc6l2

DIOPT Version :10

• Sequence 1: NP_523719.1
• Gene: Iswi / 36390
• FlyBaseID: FBgn0011604
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_038952187.1
• Gene: Ercc6l2 / 361197
• RGDID: 1561537
• Length: 1561
• Species: Rattus norvegicus
• Alignment Length: 1140
• Identity: 271/1140 - (23%)
• Similarity: 452/1140 - (39%)
• Gaps: 292/1140 - (25%)

  Fly    71 PKGRPKKI--KDKDKEKDVADHRHRKTEQEEDEE----------------LLAEDSATKEIFRFD 117
            |..:.|||  :...:.|...||.......:||.|                .|:||.        |
  Rat    56 PDFQEKKIPLQRLQEVKSTKDHSRSLIFDDEDLEKPYFPDQKIPSLVSAFQLSEDG--------D 112

  Fly   118 ASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLG-------------- 168
            :.| |..:..:||||..|..::...|..|...||.|:||||||:|.||.|.
  Rat   113 SIP-YTINRYLRDYQREGAQFLYRHYIKGRGCILGDDMGLGKTIQVISFLAAVLHKKGTREDIEN 176

  Fly   169 -----YLKHFKNQAGP-----HIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVL 223
                 .||..|.::..     .:::.|.|.|.||.:|...| ...|...|.|.:.. |...|  |
  Rat   177 NMPEFLLKSMKKESSSTARKMFLIVAPLSVLYNWKDELDTW-GYFRVTVLHGSKKD-NELTR--L 237

  Fly   224 MPGEWDVCVTSYE---MCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITG 285
            ...:.::.:|:||   :|:.|   .....|..:::||||||:|..::::|:::..|...|:.:||
  Rat   238 KQRKCEIALTTYETLRLCLEE---LNSLEWSAIIVDEAHRIRNPNARVTEVMKAVKCKVRIGLTG 299

  Fly   286 TPLQNNLHELWALLNFLLPDVFNSSEDFDEWFNTNTCLGDDALITR---------LHAVLKP--- 338
            |.||||:.|||.::::.:|.:..|...|.:.|:.....|.....|:         :|.:.|.
  Rat   300 TILQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEHGQRHTATKRELATGRKAMHRLAKKMSG 364

  Fly   339 FLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVL-LKDIDVV------------------- 383
            :.|||.|..::.:|..|::..::..|:..|:..|..|| .:|:.::
  Rat   365 YFLRRTKTLIKGQLPKKEDRMVYSSLTDFQKAVYQTVLETEDVALILTSSQPCTCGSGQKRRKCC 429

  Fly   384 ---NGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTH----------LVYN------ 429
               |..|...:....:.|..|:|..||..|...|      :|..|          .|::
  Rat   430 YKTNSQGDTVRTLCLSYLTVLQKVANHVALLQAA------STSKHQETLIKRICDQVFSRFPDFV 488

  Fly   430 ----------------SGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLD 478
                            ||||.:||:||...::...:||:||..|::||:|:.||.....:|.|||
  Rat   489 QKSKDAAFETLSDPKYSGKMKVLDQLLNHFRKHRDKVLLFSFSTKLLDVLQQYCMASGLDYRRLD 553

  Fly   479 GQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHR 543
            |.|..|:|.:.::|||...... :.::||.|||||:|...|:|||::|..|||..||||:|||:|
  Rat   554 GSTKSEERLKIVKEFNSSQDVN-ICLVSTMAGGLGLNFIGANVVILFDPTWNPANDLQAIDRAYR 617

  Fly   544 IGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMV------------IQGGRLVDNRSNQLNKD 596
            |||.:.|:|||||:..||||.:..|...|.:|..:|            :||.:  ::|..
  Rat   618 IGQCRDVKVFRLISLGTVEEIMYLRQVYKQQLHCVVVGSENAKRYFEAVQGSK--EHRGE----- 675

  Fly   597 EMLNIIRFGANQVFS--SKETDITDEDIDVILERGEAKTAEQKAALDSLG--------------- 644
                  .||.:.:|.  |:.:.:|.:.::...:.||.:       :.|||
  Rat   676 ------LFGVHNLFKLRSQGSCLTRDILETRSQPGELQ-------IISLGFWDFVVKCFIVLHLR 727

  Fly   645 ----ESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPKRERKANYAVDAYFREA 705
                |:.:.|.|....|||....:......|.:|...:..|   ......|.....||..
  Rat   728 EGQVEAGIMTATTWLKGEASAQKLETPRDPDCQEPTNVCEL---YSDMSDEESVGKAVKH----- 784

  Fly   706 LRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKVPKNTELGSD------A 764
             :||.|.  :.|....|..:....|  .:|||...:.:     ..|...|.:::..||      :
  Rat   785 -KVSGPS--RTPGSSAQLTLLQCGF--SKLFEAKCESV-----QDGDGNPVSSDGSSDEQPMCLS 839

  Fly   765 TKVQR------------EEQRKIDEAEPLTEEEIQEK-ENLLSQGFTAWTKRDFNQFIKANEK-Y 815
            .|.::            .|.:|.|..:...|:.:.:| |..|.|..::.:..:......|... .
  Rat   840 AKARQAACQKTWDSVCTSEHQKSDNIQTPDEKCVSDKSEKTLEQNVSSESDDETKCHSTAGHHCM 904

  Fly   816 GRDDIDNIAKDVEGKT--PEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQ 878
            |:.|.::...||...|  |.:.:..|.:    |.:|     ::|:.|..|.:...:::..   |.
  Rat   905 GQGDTESEDSDVIFPTQDPTQRVPKNPI----CCKL-----LLGESEDSETEDPVKVNHD---DG 957

  Fly   879 KMSRYRAPFHQLRLQYGNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWF 943
            :.:..|          ||....|:..:|:..|..:..:.|.|  ::.:|         ....|.|
  Rat   958 RQNSGR----------GNGPVSNFLYLENMTLKSVRKRKGTD--DISDE---------SDDIDMF 1001

  Fly   944 IKSRTALELQRRCNTLITLIERENIELEEKERAEKKKKAPKGSVSA--------GSG-------- 992
            .|||.     |:        :|....|:.|.:.|.|:|.....::|        ..|
  Rat  1002 PKSRI-----RK--------QRATASLKLKSKKENKRKHYNSPITAKDTNQVCEADGDCSSQVIE 1053

  Fly   993 --SASSNTPAPAPQPKASQKRKSEVVATSSNSKKK 1025
              |:|.::.:.:.........::|.|...||.:.|
  Rat  1054 DFSSSDDSSSVSHVSFTKLNHRAETVKGKSNLRNK 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	PLN03142	46..967	CDD:215601	257/1062 (24%)
Ercc6l2	XP_038952187.1	Tudor_SF	17..72	CDD:470623	4/15 (27%)
		HepA	<47..649	CDD:440319	178/615 (29%)
		DEXHc_ERCC6L2	122..369	CDD:350763	71/253 (28%)
		VIGSSK	<1132..1155	CDD:464308