DRSC/TRiP Functional Genomics Resources

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Protein Alignment Iswi and smarca4a

DIOPT Version :9

Sequence 1:NP_523719.1 Gene:Iswi / 36390 FlyBaseID:FBgn0011604 Length:1027 Species:Drosophila melanogaster
Sequence 2:NP_853634.1 Gene:smarca4a / 353295 ZFINID:ZDB-GENE-030605-1 Length:1627 Species:Danio rerio


Alignment Length:1072 Identity:346/1072 - (32%)
Similarity:524/1072 - (48%) Gaps:234/1072 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 SDAATSSSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHFMTNSAKSPTKPKGRPKKIKDKDKEK 85
            ||:..|.|.|:|   |::.|...|                     ::||:.|   |.|.|.|.| 
Zfish   673 SDSEDSGSDEEE---DDEEEPQPS---------------------QAPTEEK---KVIPDPDSE- 709

  Fly    86 DVA--DHRH--RKTEQEEDEE------------LLAEDSATKEIFRFDASPAYIKSGEMRDYQIR 134
            ||:  |.||  ...:|:.|:|            ..|...|..|  :.:...:.:.:|:::.|||:
Zfish   710 DVSEVDARHIIEHAKQDVDDEYGNSAFIRGLQSYYAVAHAVTE--KVEKQSSLLVNGQLKQYQIK 772

  Fly   135 GLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKW 199
            ||.|::|||.|.:|||||||||||||:|||:|:.||..||...||.::|||.|||.|||.||.||
Zfish   773 GLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEFKRLNGPFLIIVPLSTLSNWVYEFDKW 837

  Fly   200 CPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRYLVIDEAHRIKNE 264
            .||:..|...|....|..|: .:|..|:::|.||:||..|::|.|..|..|:|:::||.||:||.
Zfish   838 APSVVKVSYKGSPAARRAFL-PILRSGKFNVLVTTYEYIIKDKQVLAKLRWKYMIVDEGHRMKNH 901

  Fly   265 KSKLSEILR-EFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFNTNTCLGDD-- 326
            ..||:::|. .:....|:|:|||||||.|.|||||||||||.:|.|...|::|||....:..:  
Zfish   902 HCKLTQVLNTHYLAPRRVLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKV 966

  Fly   327 --------ALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVV 383
                    .:|.|||.||:||||||||.|||.:|..|.|..|...:|.:||..|..:..|.:.:.
Zfish   967 DLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLT 1031

  Fly   384 NGAGKVEKMR-----LQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYN------------SG 431
            :|:.|.:|.:     |.|.:|||||..||||:|...|.    :...||.:.            ||
Zfish  1032 DGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEE----SFSEHLGFTGGIVQGSDLYRASG 1092

  Fly   432 KMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMD 496
            |..:||::||||:....:||:|.|||.::.|:|||..:||:.|.||||.|..|||...::.||..
Zfish  1093 KFELLDRILPKLRATNHKVLLFCQMTTLMTIMEDYFAYRNFKYLRLDGTTKAEDRGMLLKNFNDP 1157

  Fly   497 NSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTV 561
            :...|:|:|||||||||:||.:||.|||:||||||..||||.||||||||:.:|||.||.|.::|
Zfish  1158 SHQYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSV 1222

  Fly   562 EEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDED----- 621
            ||||:..|:.||.:|:.|||.| :.|.:|:...:...|..|.....|  ..:|.::.|::     
Zfish  1223 EEKILAAAKYKLNVDQKVIQAG-MFDQKSSSHERRAFLQAILEHEEQ--DEEEDEVPDDETVNQM 1284

  Fly   622 -------------IDVILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWR 673
                         :|:...|.||:..:::..|  :.|..|.|:.|..:.|     |.:...|:  
Zfish  1285 IARSEEEFDHFMRMDLDRRREEARNPKRRPRL--MEEDELPTWIMKDDAE-----VERLTCEE-- 1340

  Fly   674 EKQKLNALGNWIEPPKRERK-ANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFE 737
            |::|:...|:      |:|| .:|:.....::.|:..|...                      .:
Zfish  1341 EEEKMFGRGS------RQRKEVDYSDSLTEKQWLKAIEEGT----------------------LD 1377

  Fly   738 LLDQEIYYFRKTVGYKVPKNTELGSDATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTK 802
            .:::|:.: :||..                :|:..|.:|...|.|..         |.|    ..
Zfish  1378 EIEEEVRH-KKTTR----------------KRKRDRDLDLPGPATPS---------SSG----RS 1412

  Fly   803 RDFNQFIKANEKYGRDDIDNIAKDVEG------KTPEEVIEYNAVFWERCTELQDIERIMGQIER 861
            ||.:...|..:|.||...:.::.:...      ||.:.||:|                     :.
Zfish  1413 RDKDDDGKKQKKRGRPPAEKLSPNPPSLTKKMKKTVDAVIKY---------------------KD 1456

  Fly   862 GEGK----IQRRLSIKKALDQKMSRYRAP--FHQLRLQYGNNKGKNYTEIE-DRFLVCMLHKLGF 919
            |.|:    :..:|..:|.|.:.....|.|  |.:::.:..::|.::..::| |..|:|. :...|
Zfish  1457 GNGRQLSEVFIQLPSRKELPEYYELIRKPVDFRKIKERIRSHKYRSLNDLEKDVMLLCQ-NAQTF 1520

  Fly   920 DKEN--VYEELRAAIRASPQFRFDWFIKSRTALELQRRCNTLITLIERENIELEEKERAEKKKKA 982
            :.|.  :||:                     ::.||    ::.|.: |:.||.||:|......:.
Zfish  1521 NLEGSLIYED---------------------SIVLQ----SVFTSV-RQKIEKEEEESEGDDSEE 1559

  Fly   983 PKGSVSAGSGSASSNTPAPAPQPKASQKRKSE 1014
            .:..|..||.|.|.:...   :.|.|:|.|:|
Zfish  1560 EEDDVDEGSESESRSVKV---KIKLSRKDKAE 1588

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IswiNP_523719.1 DBINO <30..67 CDD:290603 5/36 (14%)
SNF2_N 131..411 CDD:278600 141/295 (48%)
DEXDc 148..287 CDD:238005 68/139 (49%)
HELICc 422..553 CDD:238034 72/142 (51%)
HAND 697..796 CDD:286232 11/98 (11%)
SANT 797..838 CDD:197842 10/46 (22%)
SANT 799..838 CDD:238096 10/44 (23%)
SLIDE 853..965 CDD:286233 20/120 (17%)
smarca4aNP_853634.1 Med15 <65..>378 CDD:312941
QLQ 198..231 CDD:312430
SMC_N <388..>595 CDD:330553
HSA 478..550 CDD:214727
BRK 630..670 CDD:311469
SNF2_N 762..>1244 CDD:331286 232/486 (48%)
SnAC 1301..1368 CDD:317068 18/81 (22%)
Bromo_SNF2L2 1440..1545 CDD:99947 26/152 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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