Protein Alignment Iswi and Etl1

DIOPT Version :10

• Sequence 1: NP_523719.1
• Gene: Iswi / 36390
• FlyBaseID: FBgn0011604
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_609320.2
• Gene: Etl1 / 34311
• FlyBaseID: FBgn0032157
• Length: 844
• Species: Drosophila melanogaster
• Alignment Length: 703
• Identity: 235/703 - (33%)
• Similarity: 342/703 - (48%)
• Gaps: 136/703 - (19%)

  Fly    14 ENSNETTSDAATS-----SSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHFMTNSAKSPTKPKG 73
            :|.:....|...|     .|.:.::|...|:...|.:.|.|:.:.:.|    ...|.|:.::.|.
  Fly   150 DNDHSDDDDVKQSKDQVYDSDDSDSEMSTKMTGQRKKVFQFMNEASLI----ELQSVKTLSEKKA 210

  Fly    74 RPKKIKDKDKEKDVADHRHRKTEQEEDEELL--AEDSATKE-------------IFRFDAS---- 119
              ..|.|.....|.:|.|.:........:||  |::...|:             :.|.:.:
  Fly   211 --LAIIDVRPFSDWSDLRQKLESIRMSGDLLNYAQELINKQNTVAAILSKCNNMVSRLEKAISNG 273

  Fly   120 ------PAYIKSG-EMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQA 177
                  |..:.|| ::.||||.||||:..:::..:|||||||||||||:|.|:.|.|||......
  Fly   274 AGIVEQPKLLSSGLQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQ 338

  Fly   178 GPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQD----TRNTFIRDVLMPGEWDVCVTSYEM- 237
            ..|:::||.|||.||..|..:|||.|......|.||    .|..|.:|...  .:||.:|:|.:
  Fly   339 AAHLIVVPSSTLDNWEAEISRWCPELVVEKYHGSQDERRRMRGRFAKDGFT--GFDVLLTTYHIV 401

  Fly   238 --CIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLN 300
              ...|:.:|:.....|::.||||.:||..::....|.......|:|:|||||||||.||.:||.
  Fly   402 GSTPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLC 466

  Fly   301 FLLPDVF-NSSEDFDEWF-NTNTCLGD--------DALITRLHAVLKPFLLRRLKAEVEKRLKPK 355
            |::|..| .|.||....| ......||        :..|.|...::|||:|||||.:|.|.|..|
  Fly   467 FVMPKFFAKSIEDIKSLFAKKGKSDGDQDEVSQFQETQIQRAKRIMKPFVLRRLKKDVLKNLPKK 531

  Fly   356 KEMKIFVGLSKMQRDWYTKVLLKDIDVV-NGAGKV----EKMRLQNILMQLRKCTNHPYLFDGAE 415
            ..:...|.:|..|:.:|.::    :|.. |..|:|    |:..:. |:|::|:..|||.|.
  Fly   532 LSLVEKVPMSSQQKIYYHEL----VDYYSNNKGEVCSSSERAGIA-IMMEMRRIANHPLLM---- 587

  Fly   416 PGPPYTTDTHL--------------------------------VY-------------------N 429
              ..|.||.:|                                ||                   :
  Fly   588 --RHYFTDANLRGFSKRLANASSFKKTNEQYIFEELAVMSDFQVYQMMNKHEFYDVKIPDNLICD 650

  Fly   430 SGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFN 494
            |||...||.|||||:.:|.|||:|||.|.||||:|:|...|.:.:|||||.|....|...|.:||
  Fly   651 SGKFLYLDTLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFN 715

  Fly   495 MDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITES 559
            .|:|. |:|:|||:|||:||||..||..:|:|.|:||..|.||.||.||:||::.|.::|||:||
  Fly   716 GDDSI-FVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISES 779

  Fly   560 TVEEKIVERAEVKLRLDKMVI--QGGRLVDNR--------SNQLNKD--EMLN 600
            |:||.|:..||.||:|:|.:.  :.|.:.:.|        :..|:||  |.||
  Fly   780 TIEEGILMAAEEKLKLEKDITSNEKGEVHEQRCVVKLLTTALGLDKDQEEQLN 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	PLN03142	46..967	CDD:215601	228/666 (34%)
Etl1	NP_609320.2	ComEA	<192..233	CDD:441164	9/46 (20%)
		HepA	<276..795	CDD:440319	202/532 (38%)