DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and Marcal1

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_608883.1	Gene:	Marcal1 / 33709	FlyBaseID:	FBgn0031655	Length:	755	Species:	Drosophila melanogaster

Alignment Length:	895	Identity:	189/895 - (21%)
Similarity:	298/895 - (33%)	Gaps:	322/895 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KTDTAAVEATEE----NSNETTSDAAT------SSSGE--------------KEAEFDNKIEADR 43
            |:.|:|..||:.    .||.....|.:      |.:||              |.:.|.|.::|
  Fly    37 KSTTSATGATQHANNGKSNPNQPQAKSPLNFYRSPTGEQKKINRSGPTPGDNKSSSFLNALKA-- 99

  Fly    44 SRRFDFLLKQTEIFTHFMTNSAKSP-TKPKG-----RPKKIKDKDKEKDVA-------------- 88
                   :|||.  ...::..|..| .:|.|     :|......||||.||
  Fly   100 -------IKQTS--NRELSRGAAHPYQRPNGGNERNKPTLSLSSDKEKPVAVLLGNSITCNLYLI 155

  Fly    89 -DHRHRKTEQEEDEELLA--EDSATK------EIFRFDASPAYIKSGEMRDYQ------------ 132
             .||.........|:|:.  ::..||      .|:.||.|          |||
  Fly   156 STHRFAAQTSGYHEQLVTVFKNMPTKCYDGQTRIWSFDLS----------DYQSLKTHAADLKPY 210

  Fly   133 --IRGL----------------------------NWMISLYENGI------NG--ILADEMGLGK 159
              :.|:                            :.::...::|:      .|  ::.|||||||
  Fly   211 VHMNGIPKKVLDLCGQPPVVPERSVLASIEPKLADQLMPFQQDGVCFAIAQKGRIMICDEMGLGK 275

  Fly   160 TLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPS--LRAVCLIGDQDTRNTFIRDV 222
            |.|.:::..|.|    ...|.:|....||..:|........|.  :..|.::.:..
  Fly   276 TYQALAVADYFK----DDWPLLVCTTASTRDSWAKHIMDLLPKVPIHYVQVLNNNQ--------- 327

  Fly   223 LMPGEWDVCVTSYEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRL------ 281
            |..||..|.:|||.|..|.:....:..:.:::.||:|.:||.|:|.:      .||.||
  Fly   328 LYVGEAKVLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCT------TTAKRLTDQAKR 386

  Fly   282 --LITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFNTNTCLGDDAL----------ITRLHA 334
              |::|||..:...||:..|..:.....|..|     |.|..|.|..:.          :..|..
  Fly   387 VVLLSGTPALSRPLELFTQLQMIDGKFMNFME-----FTTRYCDGKQSTFGWDANGQSNLEELKV 446

  Fly   335 VLK-PFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVVNGAGKVEKMR-LQNI 397
            :|. .::|||.|.||..:|..|....:.:..:.:   |......:.:|..|...|..|.| .:.|
  Fly   447 ILHLKYMLRRTKVEVLPQLAEKNRETVVLDPALV---WTNAETKETLDAFNKELKTAKGRATEEI 508

  Fly   398 LMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDI 462
            |::.                  |.....:     |...:...|..|.::..:.:||:....|:|.
  Fly   509 LLRF------------------YARTAEV-----KTRAVCAYLKTLVKEQKKFIIFAHHRVMMDA 550

  Fly   463 LEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDS 527
            :.|:......:|.|:||||..:.|:..:..|...:|.| :.:||.:|...||.|..|::::..:.
  Fly   551 ISDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQKKSSCK-VALLSLKACNSGITLTAAEIIVFAEL 614

  Fly   528 DWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQ 592
            ||||....||..|||||||.|.|....||..:|.::.|                        .|.
  Fly   615 DWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDII------------------------WNM 655

  Fly   593 L-NKDEMLNIIRFGANQVFSSKETDITDEDIDVILERGEAKTAEQKAALDSLGESSLRTFTMDTN 656
            | ||.|:|:.:...|..:                          |||                |:
  Fly   656 LKNKQEVLSKVGIFAENL--------------------------QKA----------------TH 678

  Fly   657 GEAGTSSVYQFEGEDWREKQKLNALGNWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPK 721
            ..|.|||                                :.::.||       .|....:..|.:
  Fly   679 TAAPTSS--------------------------------HKIEEYF-------SPSTSTSLEPER 704

  Fly   722 QPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKVPKNTELGSDATKVQREE 771
            ..|.|                  || .|:..|.|......::.|||.:.|
  Fly   705 NSIKQ------------------YF-STIPAKEPPEQNNNTEMTKVNKAE 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	9/50 (18%)
		SNF2_N	131..411	CDD:278600	74/351 (21%)
		DEXDc	148..287	CDD:238005	41/150 (27%)
		HELICc	422..553	CDD:238034	40/130 (31%)
		HAND	697..796	CDD:286232	15/75 (20%)
		SANT	797..838	CDD:197842
		SANT	799..838	CDD:238096
		SLIDE	853..965	CDD:286233
Marcal1	NP_608883.1	HARP	160..215	CDD:284784	11/64 (17%)
		DEXDc	239..420	CDD:214692	49/204 (24%)
		DEXDc	265..394	CDD:238005	40/147 (27%)
		Helicase_C	518..632	CDD:278689	35/119 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467167
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840