DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and Chd1

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001245851.1	Gene:	Chd1 / 33505	FlyBaseID:	FBgn0250786	Length:	1900	Species:	Drosophila melanogaster

Alignment Length:	1271	Identity:	379/1271 - (29%)
Similarity:	561/1271 - (44%)	Gaps:	334/1271 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKTDTAAVEATEE-------------------NSNETTSDAATSSSGEKEAEFDNKIEADRSRRF 47
            |:..|.|..|.||                   ..|:||..|...:..:..|.||.|...|.....
  Fly   319 SQAATTAATAEEEEKCETIERILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEA 383

  Fly    48 DFLLK---QTEIFTHFMTNSAKSPTKPKGRPKKIKDKDKEKDVA---------DHRHRKTEQEED 100
            .||:|   .:.|...:.:.:.....|.||..|......|||:.|         |..:.:.:.|..
  Fly   384 QFLIKWKGWSYIHNTWESEATLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQ 448

  Fly   101 EELLAE--------------DSATKEIF------------------------------------- 114
            .|||..              |..|:|..
  Fly   449 HELLKSYNNVDRIIAKGSKPDDGTEEYLCKWQSLPYAESTWEDAALVLRKWQRCAEQFNDRESSK 513

  Fly   115 -----------------RFDASPAYIKSG-EMRDYQIRGLNWMISLY--ENGINGILADEMGLGK 159
                             |....|.::.|| .:||||:.||||::..:  ||.:  ||||||||||
  Fly   514 CTPSRHCRVIKYRPKFSRIKNQPEFLSSGLTLRDYQMDGLNWLLHSWCKENSV--ILADEMGLGK 576

  Fly   160 TLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLM 224
            |:|||..|..|....:..||.:.:||.||:..|..||..|.|.:..|..:||..:     |:::.
  Fly   577 TIQTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKS-----RELIQ 636

  Fly   225 PGEWDV---------CV-TSYEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTAN 279
            ..||..         |: |:||:.:::|.......|..|::|||||:||:.|.|.:.|:||.|.:
  Fly   637 QYEWQFESSKRLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNH 701

  Fly   280 RLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRL 344
            |||||||||||:|.||||||:|::||.|::.|:|:.....    .:|...||||..|:|::|||:
  Fly   702 RLLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGN----AEDKGYTRLHQQLEPYILRRV 762

  Fly   345 KAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVVNGAGKVEKMRLQNILMQLRKCTNH-- 407
            |.:|||.|..|.|..:.|.::.:|:.:|..:|.|:.|.:....:.......||:::|:||.||
  Fly   763 KKDVEKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALRKGKRGSTSTFLNIVIELKKCCNHAA 827

  Fly   408 ---PYLFD--GAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYC 467
               |..|:  |.:......|   |:..|||:.:|||||.:|:|.|.||||||||.||||:|.||.
  Fly   828 LIRPSEFELMGLQQDEALQT---LLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLADYL 889

  Fly   468 HWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQ 532
            ..|::.:.||||....|.|.:.:..||.:.|..|.|:||||||||||||||||.|||:|||||||
  Fly   890 QKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWNPQ 954

  Fly   533 MDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVIQ----GGRLV------- 586
            .||||..||||||||.||.::||:|..:|||:|||||:.|:.||.:|||    .||.|
  Fly   955 NDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSGNG 1019

  Fly   587 -DNRSNQLNKDEMLNIIRFGANQVFSSKETDITDE--DIDVILERGEAKTAEQKAALDSLGESSL 648
             .:.||..|||::..|::|||.::|..::....|.  |||.||.|.|.:..:.:...|.|    |
  Fly  1020 HSSNSNPFNKDDLSAILKFGAEELFKDEQEHDDDLVCDIDEILRRAETRNEDPEMPADDL----L 1080

  Fly   649 RTFTMDTNGEAGTSSVYQFEGE--DWREKQKLNALG------NWIEPPKRERKANYAVDAYFREA 705
            ..|.:        :|:..||.|  |...||..||.|      :|.:          .:...||:|
  Fly  1081 SAFKV--------ASIAAFEEEPSDSVSKQDQNAAGEEDDSKDWDD----------IIPEGFRKA 1127

  Fly   706 LRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTV------------GYKVPKNT 758
            :...|          :...::|. :.|||            |||.            |.|..:..
  Fly  1128 IDDQE----------RAKEMEDL-YLPPR------------RKTAANQNEGKRGAGKGGKGKQQA 1169

  Fly   759 ---------ELGSDATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEK 814
                     |||||.:   .::.|......|..:|:|           |.:|..:..:||::.:|
  Fly  1170 DDSGGDSDYELGSDGS---GDDGRPRKRGRPTMKEKI-----------TGFTDAELRRFIRSYKK 1220

  Fly   815 YGR--DDIDNIAKDVE--GKTPEEVIEYNAVFWERCT----ELQDIERIMGQIERGEGKIQRR-- 869
            :..  ..::.||.|.|  .|...|:.....:..:||.    |.::.|......:...|..|||
  Fly  1221 FPAPLHRMEAIACDAELQEKPLAELKRLGEMLHDRCVQFLHEHKEEESKTAATDETPGAKQRRAR 1285

  Fly   870 --LSIK-----------KALDQKMSRYRAPFHQL-------RLQYGNNKGKNYTEI--------E 906
              .|:|           .|.:|::.    |.:::       |.|:..|. |....:        |
  Fly  1286 ATFSVKLGGVSFNAKKLLACEQELQ----PLNEIMPSMPEERQQWSFNI-KTRAPVFDVDWGIEE 1345

  Fly   907 DRFLVCMLHKLGFDKENVYEELRAAIRASPQFRF-DWFIKSRT----ALELQRRCNTLITLIERE 966
            |..|:|.:::.|...   :|::    :..|..:. |..:.:.|    |.:||.|...|:.:| ::
  Fly  1346 DTKLLCGIYQYGIGS---WEQM----KLDPTLKLTDKILLNDTRKPQAKQLQTRAEYLLKII-KK 1402

  Fly   967 NIELEE-KERAEKKKKAPKGS-VSAGSGSASS--------------------------------- 996
            |:||.: .:|.:::.:|.:.: ..|.|.||||
  Fly  1403 NVELTKGGQRRQRRPRASRANDAKAASQSASSTIDAKPHDGEDAAGDARTVAESSNSQVDPSTAS 1467

  Fly   997 --NTPA------PAPQPKASQKRKSEVVATSSNSKK 1024
              |.||      ||.:.|.|:.|..:..|:.:|..|
  Fly  1468 PHNAPATEQHGDPAKKAKKSKARSKKTSASDNNGNK 1503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	9/39 (23%)
		SNF2_N	131..411	CDD:278600	116/296 (39%)
		DEXDc	148..287	CDD:238005	59/148 (40%)
		HELICc	422..553	CDD:238034	80/130 (62%)
		HAND	697..796	CDD:286232	22/119 (18%)
		SANT	797..838	CDD:197842	11/44 (25%)
		SANT	799..838	CDD:238096	10/42 (24%)
		SLIDE	853..965	CDD:286233	29/146 (20%)
Chd1	NP_001245851.1	CHROMO	374..422	CDD:237991	10/47 (21%)
		Chromo	458..509	CDD:278797	3/50 (6%)
		SNF2_N	548..829	CDD:278600	115/291 (40%)
		DEXDc	564..709	CDD:238005	60/151 (40%)
		Helicase_C	852..967	CDD:278689	72/114 (63%)
		DUF4208	1521..1610	CDD:290618
		DUF3824	1795..>1894	CDD:289625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467164
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840