Protein Alignment Iswi and smarca2

DIOPT Version :9

• Sequence 1: NP_523719.1
• Gene: Iswi / 36390
• FlyBaseID: FBgn0011604
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_009299900.1
• Gene: smarca2 / 334032
• ZFINID: ZDB-GENE-030131-5964
• Length: 1578
• Species: Danio rerio
• Alignment Length: 1084
• Identity: 332/1084 - (30%)
• Similarity: 492/1084 - (45%)
• Gaps: 292/1084 - (26%)

  Fly    30 EKEAEFDNKIEADRSRRFDFLLKQTE---------IFTHFMTNSAKSPTKPKGRPKKIKD----- 80
            |.|..:...|:..:.:|..:||:||:         ::.|....:||.  |.|.|.||.|:
Zfish   512 EDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVYEHKAAQAAKE--KKKKRKKKKKEAGDAE 574

  Fly    81 ------------------------------------------------------------KDKEK 85
                                                                        .|.|:
Zfish   575 GMGAIGPDGEPIDENSQMSELPVKVIQTETGKVLQGTDAPKSSQLEAWLEMNPGYEVAPRSDSEE 639

  Fly    86 DVADHRHRKTEQEEDEELLA-----------------EDSATKEIF------------------- 114
            ..:|.     |:|:|||:::                 .::|.|.|.
Zfish   640 SGSDF-----EEEDDEEVVSRAESEEKKVIDPNSDEVSETAAKHIIESAKQDVDDEYSSQAGQTS 699

  Fly   115 -------------RFDASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISL 166
                         |.|....::.:|.::.|||:||.||:|||.|.:|||||||||||||:|||.|
Zfish   700 SQSYYGVAHAVIERVDKQSTFLINGTLKQYQIQGLEWMVSLYNNNLNGILADEMGLGKTIQTIGL 764

  Fly   167 LGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVC 231
            :.||...|...||:::|||.|||.|||.|..||.||:..:...|....|.:.:.. |..|:::|.
Zfish   765 ITYLMEHKRLNGPYLIIVPLSTLSNWVYELDKWAPSIVKIAYKGTPSMRRSLVPQ-LRSGKFNVL 828

  Fly   232 VTSYEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILR-EFKTANRLLITGTPLQNNLHEL 295
            :|:||..|::|.:..|..|:|:::||.||:||...||:::|. .:....|||:|||||||.|.||
Zfish   829 ITTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPEL 893

  Fly   296 WALLNFLLPDVFNSSEDFDEWFNTNTCLGDD----------ALITRLHAVLKPFLLRRLKAEVEK 350
            |||||||||.:|.|...|::|||....:..:          .:|.|||.||:||||||||.|||.
Zfish   894 WALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVES 958

  Fly   351 RLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVVNGAGKVEKMR-----LQNILMQLRKCTNHPYL 410
            :|..|.|..|...:|.:|:..|..:..|.|.:.:|:.|.:|.:     |.|.:|||:|..||||:
Zfish   959 QLPEKVEYVIKCDMSAIQKVLYRHMQGKGILLTDGSEKDKKGKGGAKTLMNTIMQLKKICNHPYM 1023

  Fly   411 F--------------DGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLD 461
            |              :|...||      .|...|||..:||::||||:....|||:|.|||.::.
Zfish  1024 FQHIEESFAEHLGFPNGIISGP------DLYRASGKFELLDRILPKLKATNHRVLLFCQMTSLMT 1082

  Fly   462 ILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYD 526
            |||||..:||:.|.||||.|..|||...:::||.:.|..|:|:|||||||||:||..||.|:|:|
Zfish  1083 ILEDYFGYRNFLYLRLDGTTKSEDRAMLLKKFNEEGSQYFIFLLSTRAGGLGLNLQAADTVVIFD 1147

  Fly   527 SDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSN 591
            |||||..||||.||||||||:.:|||.||.|.::|||||:..|:.||.:|:.|||.| :.|.:|:
Zfish  1148 SDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAG-MFDQKSS 1211

  Fly   592 QLNKDEMLNIIRFGANQVFSSKETDITDED------------------IDVILERGEAKTAEQKA 638
            ...:...|..|.....|  :.:|.::.|::                  :|:...|.:|:..::|.
Zfish  1212 SHERRAFLQAILEHEEQ--NMEEDEVPDDETLNQMIARNEDEFELFMRMDLDRRREDARNPKRKP 1274

  Fly   639 ALDSLGESSLRTFTMDTNGEA-------------GTSSVYQFE---GEDWREKQKLNAL--GNWI 685
            .|  :.|..|.::.:..:.|.             |..|.::.:   .:...|||.|.|:  ||..
Zfish  1275 RL--MEEDELPSWILKDDAEVERLTCEEEEEKIFGRGSRHRRDVDYSDALTEKQWLRAIEDGNLE 1337

  Fly   686 EPPK----RERKANYAVDAYFRE------ALRVSEPKAPK-APRPPK------------------ 721
            |..:    :.||....||...|.      ..|...|.|.| :|.|||
Zfish  1338 EIEEEIRLKRRKRRRHVDKDVRREDGDKAKKRRGRPPAEKLSPNPPKLTKQMNAIVDTVINYRDI 1402

  Fly   722 --QPIVQDFQFFP-----PRLFELLDQEIYYFRKTVGYKVPKNTELGSDATKVQREEQRKIDEAE 779
              :.:.:.|...|     |..:||:       ||.|.:|..|.        :|:..:.|.:.:.|
Zfish  1403 SGRQLSEVFVQLPSRKELPEYYELI-------RKPVDFKKIKE--------RVRSHKYRSVSDLE 1452

  Fly   780 P-------------LTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNIAKDVEGKT 831
            .             |...:|.|...:|...|.:           |.:|..|::.|:.:.|.:.:.
Zfish  1453 KDVMLLCHNAQTYNLEGSQIYEDSIVLQSVFKS-----------ARQKITREESDDESDDDDEED 1506

  Fly   832 PEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKA 875
            ..|         |....::...::..:.|||:.|.::|.|..||
Zfish  1507 ESE---------EESKSVKVKIKLSKRDERGQDKGKKRPSRGKA 1541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	10/45 (22%)
		SNF2_N	131..411	CDD:278600	136/295 (46%)
		DEXDc	148..287	CDD:238005	63/139 (45%)
		HELICc	422..553	CDD:238034	73/130 (56%)
		HAND	697..796	CDD:286232	28/143 (20%)
		SANT	797..838	CDD:197842	7/40 (18%)
		SANT	799..838	CDD:238096	6/38 (16%)
		SLIDE	853..965	CDD:286233	8/23 (35%)
smarca2	XP_009299900.1	Forkhead_N	70..174	CDD:254796
		Med25_SD1	138..297	CDD:288132
		QLQ	173..207	CDD:286024
		HSA	439..511	CDD:214727
		BRK	592..636	CDD:197800	0/43 (0%)
		SNF2_N	729..1024	CDD:278600	136/295 (46%)
		DEXDc	746..885	CDD:238005	63/139 (45%)
		Helicase_C	1051..1166	CDD:278689	67/114 (59%)
		SnAC	1261..1328	CDD:291293	12/68 (18%)
		Bromo_SNF2L2	1384..1490	CDD:99947	20/131 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910