DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and kis

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001137761.1	Gene:	kis / 33185	FlyBaseID:	FBgn0266557	Length:	5517	Species:	Drosophila melanogaster

Alignment Length:	1066	Identity:	326/1066 - (30%)
Similarity:	487/1066 - (45%)	Gaps:	244/1066 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DTAAVEATEENSNETTSDA----ATSS--------SGEKE----------AEFDNKIEAD----- 42
            |.:||...|.:..::|.|:    ||:.        .||||          .|.|.|.|||
  Fly  1808 DQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKP 1872

  Fly    43 ------------RSRRFDFLLKQTEIFTHFMTNSAKSPTKPKGRPKK----------IKDK---- 81
                        :.|.|.:|..:.......:....:...|.:...:|          |:|:
  Fly  1873 EPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQ 1937

  Fly    82 -----DKEKDVADHRHRKT---------------------EQEEDEELLAEDSATKEIFRF---- 116
                 |:..|::.|....:                     |.|||    .::...::..||
  Fly  1938 DFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEED----VDNDKIEQYLRFNKIP 1998

  Fly   117 -------------------DASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQ 162
                               :.:|.|.....:|.||:.||||:...:.|..|.|||||||||||:|
  Fly  1999 QRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQ 2063

  Fly   163 TISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRD------ 221
            :::.:..:..: ...||.:||.|.||:.||..||:.| ..:..|...|.. |....|:|
  Fly  2064 SLTFVHSVYEY-GIRGPFLVIAPLSTIPNWQREFEGW-TDMNVVVYHGSV-TSKQMIQDYEYYYK 2125

  Fly   222 -----VLM-PGEWDVCVTSYEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANR 280
                 ||. |.:::|.:|::||.:.:....|.||||..|||||||:||...||.|.||:....:|
  Fly  2126 TESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHR 2190

  Fly   281 LLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLK 345
            :|::|||||||:.||::|||||.|..|:|.|:|...|.:   |..:..:.:|.|:|||.:|||||
  Fly  2191 VLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGS---LRTEEEVNKLQALLKPMMLRRLK 2252

  Fly   346 AEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVV-NGAGKVEKMRLQNILMQLRKCTNHPY 409
            .:|||.|.||:|..|.|.|:.:|:.:|..:|.::...: .|........|.|.:|:||||..|||
  Fly  2253 DDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMMELRKCCIHPY 2317

  Fly   410 LFDGAEPGPPYTTDT-----------HLVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDIL 463
            |.:|||....|...:           :|:.::|||.::|||||||:..|.||||||||.|.||||
  Fly  2318 LLNGAEEQIQYDFKSQHGEDPESYYKNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDIL 2382

  Fly   464 EDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSD 528
            |||..:|.|.:.|:||:.....|...|..::...|.:|:|:|.|:||||||||..||.|||||||
  Fly  2383 EDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSD 2447

  Fly   529 WNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVI-----QGGRLVDN 588
            ||||.||||..|.|||||:|.|:::||:..:|.|.::.::|.:||.|||.|:     ||.:  |.
  Fly  2448 WNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSK--DG 2510

  Fly   589 RSNQLNKDEMLNIIRFGANQVFSSKET---DITDEDIDVILERGEAKTAEQKAALDSLGESSLRT 650
            .:.||:|.|:.::::.||.......:.   ...:||||.||:|     ..|...::|...|   |
  Fly  2511 NNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDSILKR-----RTQVITMESEKGS---T 2567

  Fly   651 FTMDTNGEAGTSSVYQFEGED----WREKQKLNALGNWIEPPKRERKANYAVDAYFREALRVSEP 711
            |:..:...:|..|....:..|    |.:|..       |:|...||...        |.|.:|||
  Fly  2568 FSKASFAASGNRSDITIDDPDFWTKWAKKVD-------IDPDACERDET--------EDLVLSEP 2617

  Fly   712 KAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKT----VGYKVPKNTELGSDATKVQREEQ 772
            :..          .|..::....:.||..:|.......    :|.:..:..|....|.:.:..::
  Fly  2618 RRR----------TQIKRYGHEDVMELNSEESSNENSDEEGGIGLRSRRRKEKRDRAREKKGNDE 2672

  Fly   773 ---RKIDEAEPLTEEEIQ-----------EKENLLSQGFTAWTK-RDFNQFIKANEKYGRDDIDN 822
               |:.|....|..||||           .::.|||.|:..|:: .:..||     |.|..|:|
  Fly  2673 YIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQF-----KRGWRDVD- 2731

  Fly   823 IAKDVEGKTPEEVIEYNAVFWERCTELQDIERIM----GQIERGEGKIQRRL--SIKKALD---Q 878
                                      ::|..||:    .|:.:|:.||:..:  .|....|   |
  Fly  2732 --------------------------VEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGEVQ 2770

  Fly   879 KMSRYRAPFHQLRLQYGNNKGKNYTE 904
            |:||..:..|.| :..|.|.||:..|
  Fly  2771 KISRDHSGLHNL-VPRGRNGGKSNKE 2795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	12/63 (19%)
		SNF2_N	131..411	CDD:278600	120/292 (41%)
		DEXDc	148..287	CDD:238005	59/150 (39%)
		HELICc	422..553	CDD:238034	73/141 (52%)
		HAND	697..796	CDD:286232	22/116 (19%)
		SANT	797..838	CDD:197842	7/41 (17%)
		SANT	799..838	CDD:238096	7/39 (18%)
		SLIDE	853..965	CDD:286233	19/61 (31%)
kis	NP_001137761.1	BASP1	1554..1786	CDD:283191
		HepA	1676..2527	CDD:223627	253/730 (35%)
		SDA1	<1693..>1854	CDD:283052	12/45 (27%)
		CHROMO	<1879..1919	CDD:237991	4/39 (10%)
		Chromo	1941..1996	CDD:278797	9/58 (16%)
		DEXDc	2048..2197	CDD:238005	59/151 (39%)
		Helicase_C	2350..2464	CDD:278689	67/113 (59%)
		RR_TM4-6	3728..>3877	CDD:283990
		BRK	4569..4613	CDD:197800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467112
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840