DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and Smarca1

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001258119.1	Gene:	Smarca1 / 317575	RGDID:	1561046	Length:	1062	Species:	Rattus norvegicus

Alignment Length:	1053	Identity:	738/1053 - (70%)
Similarity:	865/1053 - (82%)	Gaps:	56/1053 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KTDTAAVEATE--------ENSNETTSD-----AATSSSGEKE--AEFDNK-----IEADRSRRF 47
            |.:.||..|||        |...:.||.     ||.:|..|||  .|::.|     ::|||::||
  Rat    35 KEEGAAAAATEATTATEKGEKKEKITSPFQLKLAAKTSKSEKEMDPEYEEKMVNIPLKADRAKRF 99

  Fly    48 DFLLKQTEIFTHFMTNSA-KSPTKP----KGRPKKIKDKDKEK--DVADHRHRKTEQEEDEELLA 105
            :|||||||:|.||:..|| ||||.|    ..|| ::|..||:.  .|.|:|||:||||||||||:
  Rat   100 EFLLKQTELFAHFIQPSAQKSPTSPLNMKLARP-RVKKDDKQSLISVGDYRHRRTEQEEDEELLS 163

  Fly   106 EDSATKEI-FRFDASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGY 169
            |...|..: .||:.||:|:|.|.:||||||||||:|||||||:|||||||||||||||||:||||
  Rat   164 ESRKTSNVCVRFEVSPSYVKGGPLRDYQIRGLNWLISLYENGVNGILADEMGLGKTLQTIALLGY 228

  Fly   170 LKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTS 234
            |||::|..|||:|:||||||.||:||||:|.||||.:|.:||:|.|..||||.:|||||||||||
  Rat   229 LKHYRNFPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGDKDVRAAFIRDEMMPGEWDVCVTS 293

  Fly   235 YEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALL 299
            |||.|:||||||||:||||||||||||||||||||||:||||:.||||:||||||||||||||||
  Rat   294 YEMVIKEKSVFKKFHWRYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALL 358

  Fly   300 NFLLPDVFNSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGL 364
            ||||||||||::|||.||:|..||||..|:.|||||||||||||:|.:|||.|.||||:||::||
  Rat   359 NFLLPDVFNSADDFDSWFDTKNCLGDQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGL 423

  Fly   365 SKMQRDWYTKVLLKDIDVVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYN 429
            |||||:||||:|:|||||:|.:||::||||.|||||||||.||||||||||||||||||.|:|.|
  Rat   424 SKMQREWYTKILMKDIDVLNSSGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSN 488

  Fly   430 SGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFN 494
            ||||..|||||.:::||||||||||||||:||||||||.||.|.|||||||||||:|...|:.||
  Rat   489 SGKMVALDKLLARIKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREEAIEAFN 553

  Fly   495 MDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITES 559
            ..||:||:|||||||||||||||:|||||:||||||||:|||||||||||||||.||||||||::
  Rat   554 APNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDN 618

  Fly   560 TVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDV 624
            ||||:||||||:|||||.:|||.|||:|.:||:|.|:|||.:||.||..||:.||:::|||||..
  Rat   619 TVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFACKESELTDEDIVT 683

  Fly   625 ILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPK 689
            ||||||.||||....:..:||||||.|.||..     .|:|:|||||:||||||..: .||||||
  Rat   684 ILERGEKKTAEMNERMQKMGESSLRNFRMDLE-----QSLYKFEGEDYREKQKLGTV-EWIEPPK 742

  Fly   690 RERKANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKV 754
            |||||||||||||||||||||||.||||||||||.|||||||||||||||::||.|:|||:||||
  Rat   743 RERKANYAVDAYFREALRVSEPKVPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKV 807

  Fly   755 PKNTELGSDATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDD 819
            |:|.||.:.|. .|||||:|||.|||||.:|.:||:.||:||||.||||||||||||||||||||
  Rat   808 PRNPELPNPAI-AQREEQKKIDGAEPLTPQESEEKDKLLTQGFTNWTKRDFNQFIKANEKYGRDD 871

  Fly   820 IDNIAKDVEGKTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYR 884
            |||:|::||||:||||:||:|||||||.||||||:||.||||||.:||||:|||||||.|::||:
  Rat   872 IDNVAREVEGKSPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDAKIARYK 936

  Fly   885 APFHQLRLQYGNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTA 949
            |||||||:|||.:|||||||.|||||:|||||:|||:||||||||..:|.:||||||||||||||
  Rat   937 APFHQLRIQYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEELRQCVRNAPQFRFDWFIKSRTA 1001

  Fly   950 LELQRRCNTLITLIERENIELEEKERAEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQKRKSE 1014
            :|.||||||||:|||:||:|:||:|||||||:|.|             ||       .|||||:|
  Rat  1002 MEFQRRCNTLISLIEKENMEIEERERAEKKKRATK-------------TP-------MSQKRKAE 1046

  Fly  1015 VVATSSNSKKKKK 1027
            ....||..|..||
  Rat  1047 SATESSGKKDVKK 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	22/44 (50%)
		SNF2_N	131..411	CDD:278600	221/279 (79%)
		DEXDc	148..287	CDD:238005	110/138 (80%)
		HELICc	422..553	CDD:238034	103/130 (79%)
		HAND	697..796	CDD:286232	74/98 (76%)
		SANT	797..838	CDD:197842	34/40 (85%)
		SANT	799..838	CDD:238096	32/38 (84%)
		SLIDE	853..965	CDD:286233	87/111 (78%)
Smarca1	NP_001258119.1	PLN03142	64..1061	CDD:215601	729/1024 (71%)
		DBINO	<96..114	CDD:290603	12/17 (71%)
		DEXDc	207..346	CDD:238005	110/138 (80%)
		Helicase_C	489..604	CDD:278689	91/114 (80%)
		HAND	750..848	CDD:286232	74/98 (76%)
		SANT	851..890	CDD:238096	32/38 (84%)
		SLIDE	905..1017	CDD:286233	87/111 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351848
Domainoid	1	1.000	469	1.000	Domainoid score	I434
eggNOG	1	0.900	-	-		E2759_KOG0385
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55711
Inparanoid	1	1.050	1490	1.000	Inparanoid score	I94
OMA	1	1.010	-	-		QHG54891
OrthoDB	1	1.010	-	-		D144251at33208
OrthoFinder	1	1.000	-	-		FOG0001113
OrthoInspector	1	1.000	-	-		otm45254
orthoMCL	1	0.900	-	-		OOG6_100877
Panther	1	1.100	-	-	LDO	PTHR10799
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1240
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810