Protein Alignment Iswi and Smarca1

DIOPT Version :10

• Sequence 1: NP_523719.1
• Gene: Iswi / 36390
• FlyBaseID: FBgn0011604
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_001258119.1
• Gene: Smarca1 / 317575
• RGDID: 1561046
• Length: 1062
• Species: Rattus norvegicus
• Alignment Length: 1053
• Identity: 738/1053 - (70%)
• Similarity: 865/1053 - (82%)
• Gaps: 56/1053 - (5%)

  Fly     3 KTDTAAVEATE--------ENSNETTSD-----AATSSSGEKE--AEFDNK-----IEADRSRRF 47
            |.:.||..|||        |...:.||.     ||.:|..|||  .|::.|     ::|||::||
  Rat    35 KEEGAAAAATEATTATEKGEKKEKITSPFQLKLAAKTSKSEKEMDPEYEEKMVNIPLKADRAKRF 99

  Fly    48 DFLLKQTEIFTHFMTNSA-KSPTKP----KGRPKKIKDKDKEK--DVADHRHRKTEQEEDEELLA 105
            :|||||||:|.||:..|| ||||.|    ..|| ::|..||:.  .|.|:|||:||||||||||:
  Rat   100 EFLLKQTELFAHFIQPSAQKSPTSPLNMKLARP-RVKKDDKQSLISVGDYRHRRTEQEEDEELLS 163

  Fly   106 EDSATKEI-FRFDASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGY 169
            |...|..: .||:.||:|:|.|.:||||||||||:|||||||:|||||||||||||||||:||||
  Rat   164 ESRKTSNVCVRFEVSPSYVKGGPLRDYQIRGLNWLISLYENGVNGILADEMGLGKTLQTIALLGY 228

  Fly   170 LKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTS 234
            |||::|..|||:|:||||||.||:||||:|.||||.:|.:||:|.|..||||.:|||||||||||
  Rat   229 LKHYRNFPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGDKDVRAAFIRDEMMPGEWDVCVTS 293

  Fly   235 YEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALL 299
            |||.|:||||||||:||||||||||||||||||||||:||||:.||||:||||||||||||||||
  Rat   294 YEMVIKEKSVFKKFHWRYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALL 358

  Fly   300 NFLLPDVFNSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGL 364
            ||||||||||::|||.||:|..||||..|:.|||||||||||||:|.:|||.|.||||:||::||
  Rat   359 NFLLPDVFNSADDFDSWFDTKNCLGDQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGL 423

  Fly   365 SKMQRDWYTKVLLKDIDVVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYN 429
            |||||:||||:|:|||||:|.:||::||||.|||||||||.||||||||||||||||||.|:|.|
  Rat   424 SKMQREWYTKILMKDIDVLNSSGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSN 488

  Fly   430 SGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFN 494
            ||||..|||||.:::||||||||||||||:||||||||.||.|.|||||||||||:|...|:.||
  Rat   489 SGKMVALDKLLARIKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREEAIEAFN 553

  Fly   495 MDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITES 559
            ..||:||:|||||||||||||||:|||||:||||||||:|||||||||||||||.||||||||::
  Rat   554 APNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDN 618

  Fly   560 TVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDV 624
            ||||:||||||:|||||.:|||.|||:|.:||:|.|:|||.:||.||..||:.||:::|||||..
  Rat   619 TVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFACKESELTDEDIVT 683

  Fly   625 ILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPK 689
            ||||||.||||....:..:||||||.|.||..     .|:|:|||||:||||||..: .||||||
  Rat   684 ILERGEKKTAEMNERMQKMGESSLRNFRMDLE-----QSLYKFEGEDYREKQKLGTV-EWIEPPK 742

  Fly   690 RERKANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKV 754
            |||||||||||||||||||||||.||||||||||.|||||||||||||||::||.|:|||:||||
  Rat   743 RERKANYAVDAYFREALRVSEPKVPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKV 807

  Fly   755 PKNTELGSDATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDD 819
            |:|.||.:.|. .|||||:|||.|||||.:|.:||:.||:||||.||||||||||||||||||||
  Rat   808 PRNPELPNPAI-AQREEQKKIDGAEPLTPQESEEKDKLLTQGFTNWTKRDFNQFIKANEKYGRDD 871

  Fly   820 IDNIAKDVEGKTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYR 884
            |||:|::||||:||||:||:|||||||.||||||:||.||||||.:||||:|||||||.|::||:
  Rat   872 IDNVAREVEGKSPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDAKIARYK 936

  Fly   885 APFHQLRLQYGNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTA 949
            |||||||:|||.:|||||||.|||||:|||||:|||:||||||||..:|.:||||||||||||||
  Rat   937 APFHQLRIQYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEELRQCVRNAPQFRFDWFIKSRTA 1001

  Fly   950 LELQRRCNTLITLIERENIELEEKERAEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQKRKSE 1014
            :|.||||||||:|||:||:|:||:|||||||:|.|             ||       .|||||:|
  Rat  1002 MEFQRRCNTLISLIEKENMEIEERERAEKKKRATK-------------TP-------MSQKRKAE 1046

  Fly  1015 VVATSSNSKKKKK 1027
            ....||..|..||
  Rat  1047 SATESSGKKDVKK 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	PLN03142	46..967	CDD:215601	691/928 (74%)
Smarca1	NP_001258119.1	PLN03142	64..1061	CDD:215601	729/1024 (71%)