DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and Smarcad1

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	XP_038963492.1	Gene:	Smarcad1 / 312398	RGDID:	1309640	Length:	1033	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	231/728 - (31%)
Similarity:	346/728 - (47%)	Gaps:	170/728 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EATEENSNETTSDAATS-----SSGEKEAE--FDNKIEADRSRRFDFLLKQTEIFTHFMTNSA-- 65
            :|.|::..::.|||.:|     ||.|:..|  :..||                  .||:.:::
  Rat   351 KAVEDSEYDSGSDAGSSLDEDYSSCEEVMEDGYKGKI------------------LHFLQDASIG 397

  Fly    66 KSPTKPKGRPKK---------------------------------IKDKDKEKDVADHRHRKTEQ 97
            :....||...||                                 .|...:|:||......|.|.
  Rat   398 ELTLIPKCSQKKAQKIIELRPFNNWETLFTKMSKINGLSEDLIWNCKTVIQERDVVIRLMNKCED 462

  Fly    98 EEDEELLAEDSATKEIFRFDAS--------PAYI-KSGEMRDYQIRGLNWMISLYENGINGILAD 153
                   ..:..||::.....:        |:.: :|..::.||..||||:..::::|:||||||
  Rat   463 -------ISNKLTKQVTMLTGNGGGWNIEQPSLLNQSLSLKPYQKVGLNWLALVHKHGLNGILAD 520

  Fly   154 EMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTF 218
            |||||||:|.|:.|.||....|: |||:::||.||:.||:.|...|||:|..:|..|.|:.|...
  Rat   521 EMGLGKTIQAIAFLAYLFQEGNK-GPHLIVVPASTIDNWLREVNLWCPTLNVLCYYGSQEERKQI 584

  Fly   219 IRDVLMPGE-WDVCVTSYEMCIR---EKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTAN 279
            ..::....| ::|.||:|...|.   ::|:|::....|.:.||.|.:||..|...:.|......|
  Rat   585 RFNIHNKYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARN 649

  Fly   280 RLLITGTPLQNNLHELWALLNFLLPDVFNSS-EDFDEWFNTNTCLGDDALITR----LHA--VLK 337
            |||:||||:||||.||.:||||::|.:|:|| .:....|::.|...|:..|..    .||  ::|
  Rat   650 RLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKPADEQSIYEKERIAHAKQIIK 714

  Fly   338 PFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVVNGAGKVEKMRLQNILMQLR 402
            ||:|||:|.||.|.|.|||:......:|:.|...|:.:..:....:|...|..:|  .|::||||
  Rat   715 PFILRRVKEEVLKLLPPKKDQIELCAMSEKQEQLYSGLFNRLKKSINNLEKNTEM--CNVMMQLR 777

  Fly   403 KCTNHPYLF--------------------DGAEPGP--------------------------PYT 421
            |..|||.|.                    ...|..|                          .|.
  Rat   778 KMANHPLLHRQYYTAEKLKEMSQLMLKEPTHCEANPDLIFEDMEVMTDFELHVLCKQYQHINSYQ 842

  Fly   422 TDTHLVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDR 486
            .|..|:.:|||...|..:|.:|:::|.||::|||.|.||||||.......:.|.||||:|...:|
  Rat   843 LDMDLILDSGKFRTLGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISER 907

  Fly   487 NRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVR 551
            ...|.|||.|... |:|:|||:||||||||.:|:|||::|.|.||..|.||.||.||:||.|:|.
  Rat   908 IHLIDEFNTDMDI-FVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVL 971

  Fly   552 VFRLITESTVEEKIVERAEVKLRLDK---MVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSK 613
            |.:||::.|:||.:::..:.||:|::   .|.:||
  Rat   972 VIKLISQGTIEESMLKINQQKLKLEQDMTTVDEGG------------------------------ 1006

  Fly   614 ETDITDEDIDVIL 626
            .:|:.|.||..:|
  Rat  1007 HSDLLDSDISGLL 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	6/40 (15%)
		SNF2_N	131..411	CDD:278600	117/290 (40%)
		DEXDc	148..287	CDD:238005	59/142 (42%)
		HELICc	422..553	CDD:238034	65/130 (50%)
		HAND	697..796	CDD:286232
		SANT	797..838	CDD:197842
		SANT	799..838	CDD:238096
		SLIDE	853..965	CDD:286233
Smarcad1	XP_038963492.1	MSCRAMM_ClfB	<18..247	CDD:411414
		PLN03142	474..>996	CDD:215601	196/525 (37%)
		DEXHc_SMARCAD1	495..677	CDD:350756	79/182 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920