DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and Chd1l

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	XP_006233080.1	Gene:	Chd1l / 310707	RGDID:	1311935	Length:	926	Species:	Rattus norvegicus

Alignment Length:	853	Identity:	286/853 - (33%)
Similarity:	435/853 - (50%)	Gaps:	125/853 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 MRDYQIRGLNWMISLYENGING-ILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQN 191
            :|.||:.|:||::..: :|.|| ||.||||||||.|||:||.||....|..||.:::.|.|.|.|
  Rat    71 LRSYQLEGVNWLVQCF-HGQNGCILGDEMGLGKTCQTIALLIYLVGRLNDEGPFLILCPLSVLSN 134

  Fly   192 WVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRYLVID 256
            |..|.:::.|.|..|...||::.|....:|:.....:.|.:|:||:|:::.|..|.|:|..|.:|
  Rat   135 WKEEMERFAPGLSCVTYTGDKEERARRQQDLRQESGFHVLLTTYEICLKDASFLKSFSWSVLAVD 199

  Fly   257 EAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVF--NSSEDFDEWFNT 319
            ||||:||:.|.|...|.||....|||:||||:||:|.||::||:.:.||:|  ...|||.:
  Rat   200 EAHRLKNQSSLLHRTLSEFSVVFRLLLTGTPIQNSLQELYSLLSVVEPDLFCREQVEDFVQ---- 260

  Fly   320 NTCLGD----DALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDI 380
              |..|    ....:.||.:|:||||||:||:|...|..|.|:.|:.|:|.:|:.:|..:|:||:
  Rat   261 --CYQDIEKESKSASELHRLLRPFLLRRVKAQVATELPKKTEVVIYHGMSALQKKYYKAILMKDL 323

  Fly   381 DVVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQE 445
            |..... ..:|::|||:|.|||||.:|||||||.|| .|:....||:..|||:.:||:||..|..
  Rat   324 DAFENE-TAKKVKLQNVLTQLRKCVDHPYLFDGVEP-EPFEVGEHLIEASGKLHLLDRLLAFLYS 386

  Fly   446 QGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAG 510
            .|.|||:|||||.|||||:||..:|.|:|.|:||....|:|:..|:.|.  ....|:|:||||||
  Rat   387 GGHRVLLFSQMTHMLDILQDYMDYRGYSYERVDGSVRGEERHLAIKNFG--KQPIFVFLLSTRAG 449

  Fly   511 GLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRL 575
            |:|:||..||.||..|||:|||.||||..|||||||.|.|:|.|||...||||.:..:|..||:|
  Rat   450 GVGMNLTAADTVIFVDSDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQL 514

  Fly   576 DKMVIQGGRL-VDNRSNQLNKD-EMLNIIRFGANQVFSSKETDITDEDIDVILERGEAKTAE-QK 637
            ..|||:||.. :..:......| ::..|::||.:::.||:.:.:.:.|:..||  ||.|..: ..
  Rat   515 TNMVIEGGHFTLGAQKPAAEADLQLSEILKFGLDKLLSSEGSSMDEIDLKSIL--GETKDGQWTP 577

  Fly   638 AALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPKRERKANYAVDAYF 702
            .||.:..|...|      ..|.|.:.:|.|||.|:.:           ||.|.:||:       |
  Rat   578 DALPAAAEGESR------EQEEGKNHMYLFEGRDYSK-----------EPSKEDRKS-------F 618

  Fly   703 REALRVSEPKAPKAP------RPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKVPKNTELG 761
            .:.:.:.:....|..      |.....::......|.:..::|..|                ||
  Rat   619 EQLVNLQKTLLEKTSHGGRSLRNKGSVLIPGLAEGPIKRKKILSPE----------------EL- 666

  Fly   762 SDATKVQRE---EQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNI 823
            .|..|.::|   :::|:.|.:...:||.:.::.:     ..|....:..|...:|....:|::::
  Rat   667 EDRQKKRQEAAAKRKKLMEEKKKAKEEAEHRKKM-----AWWESNGYQSFCLPSEDSELEDLEDL 726

  Fly   824 AKDVEGKTPEEVIEYNAVFWERCTELQDIERIMGQIER--------------------GEGKIQR 868
            .   :|......::|..:      :|..|..:.|.:..                    |.|.:..
  Rat   727 E---DGDETSAELDYEDL------DLTSINYVSGDVTHPQAGEEDAVIVHCVDDSGRWGRGGLFT 782

  Fly   869 RLSIKKALDQKMSRYRAPFHQLRL----------QYGNNKGKNYTEIEDRFLVCMLHKLGFDKEN 923
            .|..:.|..:|:.........|.|          :...:||::...     ||...|:   |:.|
  Rat   783 ALEARSAEPRKIYELAGKMKDLSLGDVLLFPIDDKESRDKGQDLLA-----LVVAQHR---DRTN 839

  Fly   924 VYEELRAA 931
            |...::.|
  Rat   840 VLSGIKMA 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603
		SNF2_N	131..411	CDD:278600	122/286 (43%)
		DEXDc	148..287	CDD:238005	62/139 (45%)
		HELICc	422..553	CDD:238034	71/130 (55%)
		HAND	697..796	CDD:286232	15/107 (14%)
		SANT	797..838	CDD:197842	5/40 (13%)
		SANT	799..838	CDD:238096	5/38 (13%)
		SLIDE	853..965	CDD:286233	17/109 (16%)
Chd1l	XP_006233080.1	SNF2_N	74..353	CDD:278600	122/286 (43%)
		DEXDc	90..230	CDD:238005	62/139 (45%)
		Helicase_C	371..484	CDD:278689	64/114 (56%)
		Macro	745..895	CDD:294024	18/111 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0385
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820