Protein Alignment Iswi and Chd9

DIOPT Version :10

• Sequence 1: NP_523719.1
• Gene: Iswi / 36390
• FlyBaseID: FBgn0011604
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_038953982.1
• Gene: Chd9 / 307726
• RGDID: 1306795
• Length: 2883
• Species: Rattus norvegicus
• Alignment Length: 1154
• Identity: 340/1154 - (29%)
• Similarity: 513/1154 - (44%)
• Gaps: 244/1154 - (21%)

  Fly    30 EKEAEFDNKIEADRSRRFDFLLKQTEIFTHFMTNSAKSPTKPK----GRPKKI---KDKDKEKDV 87
            |::...|.:|:....|   |.|:|.: ..||:.:..:.|..|.    .|..::   :|||..:.|
  Rat   732 EQQLLKDKRIQQKIKR---FKLRQAQ-RAHFLADMEEEPFNPDYVEVDRILEVSFCEDKDTGESV 792

  Fly    88 A------------DHRHRKTEQ------EEDEELLAEDSATKEIFR--------FDASPAYIKSG 126
            .            |......|.      ||.|:|.|....|:::.|        .|.|..|....
  Rat   793 VYYLVKWCSLPYEDSTWELKEDVDLAKIEEFEQLQASRPDTRQLDRPPSNIWKKIDQSREYKNGN 857

  Fly   127 EMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQN 191
            ::|:||:.||||::..:.|..|.|||||||||||:|:|:.| |........||.::|.|.||:.|
  Rat   858 QLREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFL-YEVLLTGIRGPFLIIAPLSTIAN 921

  Fly   192 WVNEFKKWCPSLRAVCLIGD--------------QDTRNTFIRDVLMPGEWDVCVTSYEMCIREK 242
            |..||:.| ..:..|...|.              :|::...||...   .:...:|::||.:...
  Rat   922 WEREFRTW-TDINVVVYHGSLISRQMIQQYEMYFRDSQGRIIRGAY---RFQAIITTFEMILGGC 982

  Fly   243 SVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVF 307
            .......||.::||||||:||:..||.|.|:.....:::|:|||||||.:.||::||:||.|..|
  Rat   983 GELNAIEWRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRF 1047

  Fly   308 NSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWY 372
            .|...|.:.|..   |..:..:.:|.|:|||.:|||||.:|||||.||:|..|.|.|:.:|:.:|
  Rat  1048 PSESTFMQEFGD---LKTEEQVQKLQAILKPMMLRRLKEDVEKRLAPKEETIIEVELTNIQKKYY 1109

  Fly   373 TKVLLKDIDVVN-GAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPG---------PPYTTDTHL- 426
            ..:|.|:...:: |||:.....|.|.:|:||||.|||||..|||..         .|..:|.||
  Rat  1110 RAILEKNFSFLSKGAGQTNVPNLVNTMMELRKCCNHPYLIKGAEEKIIGEFRDTYNPSASDFHLQ 1174

  Fly   427 --VYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQ 489
              :.::||:.::||||||::..|.:|||||||.|.|||||||...:.|.|.|:||:.....|...
  Rat  1175 AMIQSAGKLVLIDKLLPKMKAGGHKVLIFSQMVRCLDILEDYLIHKRYLYERIDGRVRGNLRQAA 1239

  Fly   490 IQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFR 554
            |..|:..:|.:|:|:|.||||||||||..||..||:|||||||.||||..|.|||||.|.|:|:|
  Rat  1240 IDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQNKAVKVYR 1304

  Fly   555 LITESTVEEKIVERAEVKLRLDKMVIQ--GGRLVDNRSN---QLNKDEMLNIIRFGANQVFSSKE 614
            |:|.::.|.::.:||.:||.|||.|:|  .||  |:..:   ||:|.|:.:::|.||......:|
  Rat  1305 LVTRNSYEREMFDRASLKLGLDKAVLQSMSGR--DSNVSGIQQLSKKEIEDLLRRGAYGAIMEEE 1367

  Fly   615 TD---ITDEDIDVILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQ 676
            .:   ..:||||.||.|                  ..:|.|:::.|...|.:...|.....|...
  Rat  1368 DEGSKFCEEDIDQILLR------------------RTKTITIESEGCGSTFAKASFVASGNRTDI 1414

  Fly   677 KLNALGNWIEPPKRERKANYAVDAYF-REALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLD 740
            .|:....|   .|..:||...:||.. |.:|.:..|:..|..||        |......|.||.:
  Rat  1415 SLDDPNFW---QKWAKKAELDLDAISGRNSLVIDTPRIRKQTRP--------FSATKDELAELSE 1468

  Fly   741 QEIYYFRKTVGYKVPKNTELGSDATKVQREEQRKIDEAEPLTEEE-IQEKENLLSQGFTAWT--- 801
            .|      :.|.:.||              .:|..|.:......| .:.::|||..|:..|.
  Rat  1469 AE------SEGEEKPK--------------LRRPCDRSGGYGRTECFRVEKNLLVYGWGRWREIL 1513

  Fly   802 -----KRDFNQFIKANEKYGRDDIDNIAKD------VEGKTPEEVIEYNAVFWERCT-------- 847
                 ||..|:          .|::.|.:.      |..:..|::   ....|:..|
  Rat  1514 SHGRFKRQLNE----------HDVEVICRALLAYCLVHYRGDEKI---KGFIWDLITPTEDGQTR 1565

  Fly   848 ELQDIERIMGQIERG-EGK----------IQR------------------RLSIKKALDQKMSRY 883
            |||:...:...:.|| :||          ||:                  :..:|...::.:.|.
  Rat  1566 ELQNHLGLSAPVPRGRKGKKVKTQTSSFDIQKAEWLRKYNPEQLLQDEGYKKHVKHHCNKVLLRV 1630

  Fly   884 RAPFHQLRLQYGNNKGKNYTEIE-------------------------DRFLVCMLHKLGFDKEN 923
            |..::..:...||...|.:..::                         |:.|:..:.|.|::|.|
  Rat  1631 RMLYYLKQEVIGNESQKVFDGVDASDIDVWVPEPDHSEVPAAWWDFDADKSLLIGVFKHGYEKYN 1695

  Fly   924 VYEELRAAIRASPQFRFDWFI--KSRTALELQRRCNTLITLIERENIELEE--------KERAEK 978
                   .|||.|...|...:  ....|:..::|.|..:.    .::|..|        |:..|.
  Rat  1696 -------TIRADPALCFLERVGKPDEKAVAAEQRANDYMD----GDVEDPEYKPAPAIFKDDIED 1749

  Fly   979 KKKAPKGSVSA-GSGSASSNTPAPAPQPKASQKRKSEVVATSSNSKKKK 1026
            ...:|...|.| |.|..........|.|.|...|...::.....:.|.:
  Rat  1750 DVSSPGDLVIADGEGQLMEGDKVYWPTPSALTTRLRRLITAYQRTNKNR 1798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	PLN03142	46..967	CDD:215601	322/1068 (30%)
Chd9	XP_038953982.1	KLF3_N	217..375	CDD:410554
		PTZ00121	<510..>765	CDD:173412	9/36 (25%)
		CD1_tandem_CHD5-9_like	685..749	CDD:349315	4/19 (21%)
		CD2_tandem_CHD5-9_like	769..827	CDD:349310	11/57 (19%)
		PLN03142	858..>1479	CDD:215601	252/679 (37%)
		BRK	2475..2515	CDD:462196
		BRK	2549..2593	CDD:197800