DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and HELLS

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001275996.1	Gene:	HELLS / 3070	HGNCID:	4861	Length:	884	Species:	Homo sapiens

Alignment Length:	846	Identity:	279/846 - (32%)
Similarity:	413/846 - (48%)	Gaps:	228/846 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKTDTAAVEAT--EENSNETTSDAATSSSGEKEAE-----FDNKIEADRSRRFDFLLKQTEIFT 58
            :.:.|||.:...  ||   |...:||......|..|     :|.:....|.||...||:::.|::
Human    18 VEQLDTAVITPAMLEE---EEQLEAAGLERERKMLEKARMSWDRESTEIRYRRLQHLLEKSNIYS 79

  Fly    59 HFMTNSAK-------------------------------SPTKPKGRPKK-----------IKDK 81
            .|:....:                               |..||..|.|:           :..|
Human    80 KFLLTKMEQQQLEEQKKKEKLERKKESLKVKKGKNSIDASEEKPVMRKKRGREDESYNISEVMSK 144

  Fly    82 DKEKDVADHRHRKTEQE---------------EDEELLAEDSATKEI-----FRFD--------- 117
            ::...||....::.|.|               :|...:.:|..::.:     |.||
Human   145 EEILSVAKKNKKENEDENSSSTNLCVEDLQKNKDSNSIIKDRLSETVRQNTKFFFDPVRKCNGQP 209

  Fly   118 ---ASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGP 179
               ..|.:...|.||.||:.|:.|:..|:|||||||||||||||||:|.|:.:..:.. :...||
Human   210 VPFQQPKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQ-RGVPGP 273

  Fly   180 HIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDV--------LMPGEWDVCVTSYE 236
            .:|..|.|||.||:.|||::.|.:..:...|.|:.|...:|::        :.|    |.:||:|
Human   274 FLVCGPLSTLPNWMAEFKRFTPDIPTMLYHGTQEERQKLVRNIYKRKGTLQIHP----VVITSFE 334

  Fly   237 MCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNF 301
            :.:|:::..:...|:||::||.|||||.|.:|...|:.|...|:||:|||||||||.|||:||||
Human   335 IAMRDRNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNF 399

  Fly   302 LLPDVFNSSEDFDEWFNTNTCLGDDA--------------------------------------- 327
            ||||||:..:.|:.||:. |.|.:.|
Human   400 LLPDVFDDLKSFESWFDI-TSLSETAEDIIAKEREQNVLHMLHQERIPRMYVSEFTDEGFFEGKL 463

  Fly   328 ---------------LITRLHA---VLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTK 374
                           .:.:||.   :|.||||||||::|...:.||:|:.::..|||.|..:||.
Human   464 PSRKDLYDIRPYENTYLLKLHTNFEILTPFLLRRLKSDVALEVPPKREVVVYAPLSKKQEIFYTA 528

  Fly   375 VLLKDIDVVNGAGKVE------------------------------------------------- 390
            ::.:.|..:.|:.:.|
Human   529 IVNRTIANMFGSSEKETIELSPTGRPKRRTRKSINYSKIDDFPNELEKLISQIQPEVDRERAVVE 593

  Fly   391 ---------KMRLQNILMQLRKCTNHPYLFDGAEPGPPYT----TDTHLVYNSGKMAILDKLLPK 442
                     .::||||:|.||||.|||||.:  .|..|.|    .|..||.||||..|||::||:
Human   594 VNIPVESEVNLKLQNIMMLLRKCCNHPYLIE--YPIDPVTQEFKIDEELVTNSGKFLILDRMLPE 656

  Fly   443 LQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLST 507
            |:::|.:||:|||||.|||||.||||.|::|:.||||...:.:|.:.:..||.|... |:|::||
Human   657 LKKRGHKVLLFSQMTSMLDILMDYCHLRDFNFSRLDGSMSYSEREKNMHSFNTDPEV-FIFLVST 720

  Fly   508 RAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVK 572
            |||||||||..||.|||||||||||.||||.||.|||||.|.|.|:||:|.:|:::||||||..|
Human   721 RAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAK 785

  Fly   573 LRLDKMVI-----QGGRLVDNRS-NQLNKDEMLNII--RFGANQVFSSKETDITDEDIDVILERG 629
            .:|:|::|     :||:...|.| |.|:..|::.::  |....::..|:|..|:|:|::::|:|.
Human   786 RKLEKLIIHKNHFKGGQSGLNLSKNFLDPKELMELLKSRDYEREIKGSREKVISDKDLELLLDRS 850

  Fly   630 E 630
            :
Human   851 D 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	10/72 (14%)
		SNF2_N	131..411	CDD:278600	129/402 (32%)
		DEXDc	148..287	CDD:238005	57/146 (39%)
		HELICc	422..553	CDD:238034	79/130 (61%)
		HAND	697..796	CDD:286232
		SANT	797..838	CDD:197842
		SANT	799..838	CDD:238096
		SLIDE	853..965	CDD:286233
HELLS	NP_001275996.1	SNF2_N	221..>869	CDD:331286	245/640 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0385
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	1	1.000	-	-		FOG0001113
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820