Protein Alignment Iswi and Ercc6

DIOPT Version :10

• Sequence 1: NP_523719.1
• Gene: Iswi / 36390
• FlyBaseID: FBgn0011604
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_001423629.1
• Gene: Ercc6 / 306274
• RGDID: 1311509
• Length: 1474
• Species: Rattus norvegicus
• Alignment Length: 1021
• Identity: 267/1021 - (26%)
• Similarity: 432/1021 - (42%)
• Gaps: 238/1021 - (23%)

  Fly    14 ENSNETTSDAATSSSGEKEAEFDNK----IEAD----------RSRRFDFLLKQTEIFTHFMTNS 64
            |...|.....::.:.||:|.|.:.:    :.:|          :.::::..:...||...|..:|
  Rat   364 EGDTEGEESGSSPTDGEEEEEQEEEGVAVLSSDDISYELKPLRKGQKYEKKVPVQEIDDDFFPSS 428

  Fly    65 AKSPTKPKGR--PKKI--KDKDKEKDVADHRHRKTEQ---EEDEELLAEDSATKEIFRFDAS--- 119
            .:.....:||  .:|:  :..|.::|....|.|:..:   ::.|:|..||.:.:....||..
  Rat   429 EEEDEAVEGRGGGRKVSRRPDDGDEDYYKQRLRRWNRLRLQDKEKLKLEDDSEESDAEFDEGFKV 493

  Fly   120 PAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQA------- 177
            |.::.. ::..||..|:.|:..|:.....|||.||||||||:|.|:.|..|.:.|.:.
  Rat   494 PGFLFK-KLFKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRF 557

  Fly   178 ---GPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDT------RNTFIRDVL-MPGEWDVCV 232
               ||.:::.|.:.:..||.||..|.|..|...|   .:|      :...:||:: ..|   |.:
  Rat   558 EGLGPTLIVCPTTVMHQWVKEFHTWWPPFRVAIL---HETGSCAHRKERLVRDIVHCHG---VLI 616

  Fly   233 TSYEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWA 297
            |||......:....:.:|.|:::||.|:|:|..:.::...::|:|.:|::::|:|:||||.|||:
  Rat   617 TSYSYIRLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWS 681

  Fly   298 LLNFLLPDVFNSSEDFDEWFNTNTCLGDDALITR------------LHAVLKPFLLRRLKAEVEK 350
            |.:|..|....:...|.|.|:....:|..:..:.            |...:.|:||||:|::|:.
  Rat   682 LFDFTFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKM 746

  Fly   351 RLK--PKKEMKIFVGLSKMQRDWYTKVLLKDID------VVNGAGKVEKMRLQNILMQLRKCTNH 407
            .|.  .|.|..:|..|:..|.    ||....||      ::||..::     .:.|:.|||..||
  Rat   747 SLSLPDKNEQVLFCRLTDEQH----KVYQNFIDSKAVYRILNGENQI-----FSGLVALRKICNH 802

  Fly   408 PYLFDGAEPGPPYTT--------DTHLVY--NSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDI 462
            |.||.|   ||..|:        :....|  .||||.:::.||....:||.|||:|||..:||.|
  Rat   803 PDLFSG---GPKNTSALPEDGLEEEQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLHI 864

  Fly   463 LEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDS 527
            ||.:.....|:|.::||.|....|...|.::|.|.|. |:|:|:||.||||:||..|:.|||||.
  Rat   865 LEVFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSI-FVFLLTTRVGGLGVNLTGANRVIIYDP 928

  Fly   528 DWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQ 592
            ||||..|.||.:||.||||||||.|:||:|..|:||||..|...|..|...|::     |.:..:
  Rat   929 DWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLK-----DPKQRR 988

  Fly   593 LNKD----EMLNIIRFGANQ------VFSS--------------------------KETDITDED 621
            ..|.    |:..:....|:|      :|:.                          |:..::|..
  Rat   989 FFKSNDLYELFTLTSPDASQGTETSAIFAGTGSNIQTLKCHFKKRTPPVLQMDPKRKKPLVSDTS 1053

  Fly   622 ID--VILER---------------------------------GEAKTAEQKAALDSL----GESS 647
            ::  .::|.                                 |..:.|:..:.|:.|    |:|.
  Rat  1054 VNGATVMEEKSQGSGATGSVPSTESGPLKSDRHTDGSRASSVGFGEEADAGSTLEHLSGLSGDSP 1118

  Fly   648 LRTFTMDTNGEAGTSSVY--QFEGEDWREKQKLNALGNWIEPPKRERKANYAVDAYFREALRVSE 710
            ....|...:..|.||...  .:|||..:.:.....|....|....:.|:....||       ..|
  Rat  1119 AVDHTSRLSAVASTSEKQGSSYEGECCQAQTGPVHLSEQTEGHFSKHKSKRKHDA-------AEE 1176

  Fly   711 PKAPKAPRPPKQPIV-----QDFQFFPPRLFELLDQEIYY-----------------------FR 747
            ....|.|: |||...     :|.:|...|:..|:.:..|:                       |:
  Rat  1177 ETTEKCPQ-PKQKAKNSRHHRDAKFEGTRVPHLVKKRRYHQQTTEQESGAKDRSSDDYVLEKLFK 1240

  Fly   748 KTVG-YKVPKNTEL--GS--DATKVQREEQRKIDEAEPLTEEEIQEKENL-LSQGFTAWT----- 801
            |:|| :.|.|:..:  ||  |...|:.|..|...:|  |....:..::.| .:.|...||
  Rat  1241 KSVGVHSVVKHDAIIDGSSPDYVLVEAEANRVAQDA--LKALRLSRQQCLGATSGVPTWTGHRGI 1303

  Fly   802 -------KRDFNQFIKANEKYG-------RDDIDNIAKDVEGKTPE 833
                   |:.|.|  |.|....       .:...|:.|:.|..|.|
  Rat  1304 SGAPAGVKKRFGQ--KRNSSLPVQRPSSLTERTQNMKKEGEAHTAE 1347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	PLN03142	46..967	CDD:215601	260/975 (27%)
Ercc6	NP_001423629.1	cc_ERCC-6_N	83..159	CDD:411064
		HepA	316..981	CDD:440319	200/636 (31%)
		CSB_WHD	1402..1473	CDD:439329