Protein Alignment Iswi and CHD5

DIOPT Version :10

• Sequence 1: NP_523719.1
• Gene: Iswi / 36390
• FlyBaseID: FBgn0011604
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_056372.1
• Gene: CHD5 / 26038
• HGNCID: 16816
• Length: 1954
• Species: Homo sapiens
• Alignment Length: 1130
• Identity: 331/1130 - (29%)
• Similarity: 505/1130 - (44%)
• Gaps: 275/1130 - (24%)

  Fly    75 PKKIKDKDKEKDVADHRHRKTEQEEDEELLAEDSATKEIFRFDASPAYIKS--GEMRDYQIRGLN 137
            ||::..|.|       :.|..:||:..:....|...|    ||..|.||.|  |.:..||:.|||
Human   656 PKRLLKKGK-------KLRDDKQEKPPDTPIVDPTVK----FDKQPWYIDSTGGTLHPYQLEGLN 709

  Fly   138 WMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPS 202
            |:...:..|.:.|||||||||||:|||..|..|....:..||::|..|.||:.||..||:.|.|.
Human   710 WLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPD 774

  Fly   203 LRAVCLIGDQDTRN-------TFIRDVLMPG------------EWDVCVTSYEMCIREKSVFKKF 248
            ...|...||:::|:       :|..:.:..|            ::.|.:||||:...::::....
Human   775 FYVVTYTGDKESRSVIRENEFSFEDNAIRSGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSI 839

  Fly   249 NWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDF 313
            .|..||:|||||:||.:||...:|..:|...:||:|||||||||.||:.|||||.|:.||:.|.|
Human   840 EWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGF 904

  Fly   314 DEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLK 378
            .|.|   ..:..:..|.:||.:|.|.:||||||:|.|.:..|.|:.:.|.||:||:.:|..:|.:
Human   905 LEEF---ADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTR 966

  Fly   379 DIDVVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTD-----THLVYNSGKMAILDK 438
            :.:.:|..|...::.|.||:|.|:||.||||||..|....|...:     :.||.:|||:.:|.|
Human   967 NFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLVKSSGKLMLLQK 1031

  Fly   439 LLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLF 503
            :|.||:::|.|||||||||:|||:|||:..:..|.|.|:||......|...|..||...:.:|.|
Human  1032 MLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCF 1096

  Fly   504 MLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVER 568
            :||||||||||||||||.||||||||||..|:||..|||||||.|:|.::|.:|.::|||:|.:.
Human  1097 LLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQV 1161

  Fly   569 AEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDVILERGE--- 630
            |:.|:.|..:|::.|  :.::|..:.|.|:.:|::||..::|.        :|::.::.:|:
Human  1162 AKRKMMLTHLVVRPG--LGSKSGSMTKQELDDILKFGTEELFK--------DDVEGMMSQGQRPV 1216

  Fly   631 --------------AKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFE----------GED 671
                          |.:|::|......|:          |.:...|||..::          .:|
Human  1217 TPIPDVQSSKGGNLAASAKKKHGSTPPGD----------NKDVEDSSVIHYDDAAISKLLDRNQD 1271

  Fly   672 WREKQKLNALGNWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLF 736
            ..:..:|..:..::...|   .|.|.|    ||...|.|         .::.|::..:...|..:
Human  1272 ATDDTELQNMNEYLSSFK---VAQYVV----REEDGVEE---------VEREIIKQEENVDPDYW 1320

  Fly   737 ELLDQEIY---------------YFRKTVGYKVPKNTE---------------LGSD-------- 763
            |.|.:..|               ..||.|.|......:               :||:
Human  1321 EKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQEWQDELSDNQSEYSIGSEDEDEDFEE 1385

  Fly   764 -----ATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDN- 822
                 :.:.|...|.|.|..:||.....:...|:...||.|   |....|:.|..::|....|.
Human  1386 RPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNA---RQRKAFLNAIMRWGMPPQDAF 1447

  Fly   823 ----IAKDVEGKTPEEVIEYNAVFWERCTE----------------------------------- 848
                :.:|:.||:.:|...|.::|.....|
Human  1448 NSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLVRK 1512

  Fly   849 -LQDIERIMGQI-------ERGEGKIQRRLSIKKALDQKMSRYRAPFHQLRLQYGNNKGKNYTEI 905
             :|:.|.:.|:.       |..|||....:.   :.|.......:|.|.|....|         :
Human  1513 KVQEFEHVNGKYSTPDLIPEGPEGKKSGEVI---SSDPNTPVPASPAHLLPAPLG---------L 1565

  Fly   906 EDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQRRCNTLITLIERENIEL 970
            .|:    |..:||:..|.           .|..:     |.|..||:|    .|...::|  :|.
Human  1566 PDK----MEAQLGYMDEK-----------DPGAQ-----KPRQPLEVQ----ALPAALDR--VES 1604

  Fly   971 EEK------------ERAEKKKKAPKG----------------------SVSAGSGSASSNTPAP 1001
            |:|            ||.|:.:|||..                      |:....|.:|...|
Human  1605 EDKHESPASKERAREERPEETEKAPPSPEQLPREEVLPEKEKILDKLELSLIHSRGDSSELRP-- 1667

  Fly  1002 APQPKASQKRKSEVVATSSNSKKKK 1026
             ...||.:|   |.:.|..|..|::
Human  1668 -DDTKAEEK---EPIETQQNGDKEE 1688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	PLN03142	46..967	CDD:215601	311/1035 (30%)
CHD5	NP_056372.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..134
		CHDNT	145..200	CDD:462357
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..338
		Histone-binding	343..653
		PHD1_CHD_II	345..387	CDD:277006
		PHD2_CHD_II	418..460	CDD:277007
		CD1_tandem_CHD3-4_like	465..544	CDD:349314
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..571
		CD2_tandem_CHD3-4_like	589..642	CDD:349309
		PLN03142	698..>1214	CDD:215601	220/528 (42%)
		DEAH box	847..850		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1209..1253		6/53 (11%)
		DUF1087	1298..1351	CDD:461922	10/61 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1351..1411		9/59 (15%)
		CHDII_SANT-like	1389..1529	CDD:461920	25/142 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1524..1564		8/42 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1597..1640		10/44 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1658..1696		10/37 (27%)
		CHDCT2	1733..1878	CDD:462358