DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and mit1

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_595385.1	Gene:	mit1 / 2541336	PomBaseID:	SPBP35G2.10	Length:	1418	Species:	Schizosaccharomyces pombe

Alignment Length:	1035	Identity:	309/1035 - (29%)
Similarity:	472/1035 - (45%)	Gaps:	218/1035 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 THFMTNSAKSPTKPKGRPKKIKDKDKEKDVADHRHR-----KTEQEEDEELLAEDSATKEI---- 113
            |::|:|....|              ||.|    |:|     |...:..|.|..|.:.|..|
pombe   491 TYYMSNWEPPP--------------KETD----RNRWKAWLKGYSDLLECLWIEKAPTASINIDL 537

  Fly   114 ----FRFDASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFK 174
                ..:.:.|::||.|.:..||::||||:...:......|||||||||||:|.||.:..| .::
pombe   538 PFTNLEWHSQPSFIKGGTLMPYQLKGLNWLYLRWYTHHPCILADEMGLGKTVQVISFISVL-FYR 601

  Fly   175 NQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWD-------VCV 232
            ::..|.:||||.:|:.||..|.|||.|.|:...|:|.:..| :.:||..:..:.|       |.|
pombe   602 HKCFPVLVIVPHATVANWERELKKWAPFLQINVLVGSEKNR-SLVRDYRLINQKDPKHVSTHVLV 665

  Fly   233 TSYEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWA 297
            .|.....||.|:.:||.|:.|::||..|:||::|.|...|...|:..:||:||||||||:.||:.
pombe   666 ISASNVEREISLLRKFQWKVLIVDEGQRLKNDQSSLFYYLSSVKSDFKLLLTGTPLQNNVRELFN 730

  Fly   298 LLNFLLPDVFNSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFV 362
            ||.||.|...|::|     ......:.|...:|.||.:||||.|||:|:||......|.|:.|.:
pombe   731 LLQFLNPMKINAAE-----LEKRYSIIDTEKVTELHQILKPFFLRRVKSEVLDNFPTKVEVIIPL 790

  Fly   363 GLSKMQRDWYTKVLLKDIDVV---------NGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGP 418
            .::.:|:..|..:|.|::.::         :.:|......|.||||||||...|||::.
pombe   791 SMTPVQKGLYKSILSKNLSLLRNITGYANTSSSGGQRTTSLNNILMQLRKTLAHPYIYS------ 849

  Fly   419 PYTTDTHLVYN---------SGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNY 474
            |...|.:|.|.         |.|..||..|:|||..:|.|:|:|||..:.||||||:..::|..|
pombe   850 PDIEDRNLPYELAMRSLEEASCKFLILRLLVPKLITRGHRILLFSQFIQQLDILEDWFEYKNIAY 914

  Fly   475 CRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMD 539
            .|.||.:...:|...|..||..||....|:|||||||:|||||:||.|||.|.|:||..|:||:.
pombe   915 ARFDGASSEMERQSAIDSFNAPNSELSCFLLSTRAGGVGINLASADTVIILDPDFNPHQDMQAIA 979

  Fly   540 RAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRF 604
            ||||.||||:|.||.|.|..:|||||::.|:.||.||.::::.   :|...|  ::.::.:|:|.
pombe   980 RAHRYGQKKKVLVFVLTTRDSVEEKIIQNAQKKLVLDHLIVES---LDQNHN--SEKDLESILRH 1039

  Fly   605 GANQVF--SSKETDITDEDIDVILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQF 667
            ||..:|  :..|..|...:..|.|...||:..|..:..:|..:|:...|....:.:..:|:.|:.
pombe  1040 GARALFEEAGDEPSIKYNEYSVELLISEAEKQEDTSTDESDIKSNKFGFFRVWDNKHISSNHYEV 1104

  Fly   668 -------EGEDW----REKQKLNALGNWIEPPKRER-KANYAVDAYFREALRVSEPKAPKAPRPP 720
                   |.:.|    ::::|...|....|.....| :|::.:  ::.|.|.:
pombe  1105 KENVLVDEEDVWSVILKQREKDAMLEKTDETTSNRRLRAHHKI--HYGEDLNI------------ 1155

  Fly   721 KQPIVQDFQFFPPRLFELLDQEIYYF--RKTVGYKVPKNTELGSDATKVQREEQR-KIDEA---E 779
                           ::..|...|..  |.:.|...|..||..|..|....::|: |.|.:   |
pombe  1156 ---------------YDNSDDTDYTVNDRSSPGSPFPIETETISSITDTLSDKQKLKYDSSVNIE 1205

  Fly   780 PLTEEEIQEK------ENLLSQGFTAWTKR--DFNQFIK------ANE----KYGRDDIDNIAKD 826
            .|.:|...:|      :::|::...|.|.:  :||:.:.      ||:    :|..|....:..|
pombe  1206 NLNDESDSQKSADVHFDSILAKSLLATTPKEDEFNKTLSTINLEVANKLTSSEYINDSEMQLIDD 1270

  Fly   827 VEGKTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFHQLR 891
            .....|.|:||.|             .:::|          |.|| |..||.        |..|.
pombe  1271 PVFYPPYEIIEKN-------------HQLVG----------RSLS-KAVLDN--------FFLLS 1303

  Fly   892 LQYGNNKGK-------------NYTEIEDRFLVCMLHKLGFD-------KENVYEELRAAIRASP 936
            ....|.:.:             :...:|..||....|..|.|       ||.:| .|:
pombe  1304 SLSDNVRCRCCGIKHLPAHCPLSIVPLEICFLCGTPHFSGRDTCPMLRNKEAIY-RLK------- 1360

  Fly   937 QFRFDWFIKSRTALELQRRCNTLITLIERENIELEEKERAEKKKKAPKGSVSAGSGSASS 996
                |...|||....::::.      :.|.|..|::||.       |..|.||.:...||
pombe  1361 ----DSLSKSREPFHIKKQA------MARLNSFLQKKEE-------PTVSSSAKTNELSS 1403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	3/8 (38%)
		SNF2_N	131..411	CDD:278600	113/295 (38%)
		DEXDc	148..287	CDD:238005	58/145 (40%)
		HELICc	422..553	CDD:238034	68/139 (49%)
		HAND	697..796	CDD:286232	19/110 (17%)
		SANT	797..838	CDD:197842	12/52 (23%)
		SANT	799..838	CDD:238096	12/50 (24%)
		SLIDE	853..965	CDD:286233	24/131 (18%)
mit1	NP_595385.1	PHD	214..268	CDD:214584
		SNF2_N	559..847	CDD:278600	112/294 (38%)
		DEXDc	577..720	CDD:238005	58/144 (40%)
		Helicase_C	870..985	CDD:278689	60/114 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870