back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and chd-3

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_510140.1	Gene:	chd-3 / 181421	WormBaseID:	WBGene00000482	Length:	1787	Species:	Caenorhabditis elegans

Alignment Length:	1097	Identity:	314/1097 - (28%)
Similarity:	484/1097 - (44%)	Gaps:	283/1097 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RPKKIKD---KDKEKDVADHRHRKTEQEEDEELLAEDSATKEI---FRFDASPAYIK--SGEMRD 130
            |.:.:.|   ::.:|.:|..|..|....:::|:.:.....::|   .:::..|.:|.  .|.:..
Worm   554 RERMLNDEVPRNVQKMIAKQREAKGLGPKEDEVTSRRKKREKIDILKKYEVQPDFISETGGNLHP 618

  Fly   131 YQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNE 195
            ||:.|:||:...:.||.:.|||||||||||:|:::.|..|....:..||.::..|.||:.||..|
Worm   619 YQLEGINWLRHCWSNGTDAILADEMGLGKTVQSLTFLYTLMKEGHTKGPFLIAAPLSTIINWERE 683

  Fly   196 FKKWCPSLRAVCLIGDQDTRN-------TFIRDVLMPG------------EWDVCVTSYEMCIRE 241
            .:.|||....|..:||:::|.       :|:...:..|            ::.|.:||||....:
Worm   684 AELWCPDFYVVTYVGDRESRMVIREHEFSFVDGAVRGGPKVSKIKTLENLKFHVLLTSYECINMD 748

  Fly   242 KSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDV 306
            |::....:|..||:|||||:||.:|...:.|||:....|:|:|||||||||.||:.|||||.||.
Worm   749 KAILSSIDWAALVVDEAHRLKNNQSTFFKNLREYNIQYRVLLTGTPLQNNLEELFHLLNFLAPDR 813

  Fly   307 FNSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDW 371
            ||..|.|...|:.   :..:..|.:||.:|.|.:||||||:|...:..|:|:.:.|.||.||:.:
Worm   814 FNQLESFTAEFSE---ISKEDQIEKLHNLLGPHMLRRLKADVLTGMPSKQELIVRVELSAMQKKY 875

  Fly   372 YTKVLLKDIDVVNGAGKVEKMRLQNILMQLRKCTNHPYLF-----------DGAEPGPPYTTDTH 425
            |..:|.::.|.:|......:|.|.||:|:|:||.||||||           :|...|      :.
Worm   876 YKNILTRNFDALNVKNGGTQMSLINIIMELKKCCNHPYLFMKACLEAPKLKNGMYEG------SA 934

  Fly   426 LVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQI 490
            |:.|:||..:|.|:|.||::.|.|||||||||.|||||||:|....|.|.|:||....:.|...|
Worm   935 LIKNAGKFVLLQKMLRKLKDGGHRVLIFSQMTMMLDILEDFCDVEGYKYERIDGSITGQQRQDAI 999

  Fly   491 QEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRL 555
            ..:|...:.:|:|:||||||||||||||||.||||||||||..|:||..||||:|||.:|.::|.
Worm  1000 DRYNAPGAKQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRLGQKHKVMIYRF 1064

  Fly   556 ITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDE 620
            :|:.:|||:|...|:.|:.|..:|::.| |.......::|.|:.:::|:|..::|..:|..:...
Worm  1065 VTKGSVEERITSVAKKKMLLTHLVVRAG-LGAKDGKSMSKTELDDVLRWGTEELFKEEEAPVEGA 1128

  Fly   621 D--------------------IDVILERG---EAKTAEQKAALDSLGESSLRTFTMDTNGEA--- 659
            |                    :|.:|:|.   |.:..|:|....:...||.:..|.:|. ||
Worm  1129 DGEGTSSKKPNEQEIVWDDAAVDFLLDRNKEEEGQDGEKKEHWTNEYLSSFKVATYNTK-EADDA 1192

  Fly   660 ------------GTSS----------VYQFEGEDWREKQKLNALGNWIEPPKRERKANYA----- 697
                        ||..          .:.:|.:...|.|||.      :..:..|:.|||
Worm  1193 DDDEDETEVIKEGTEEQDPNYWEKLLKHHYEQDQETELQKLG------KGKRVRRQVNYASENMG 1251

  Fly   698 ----------------------------VDAYFREALRVSEPKAPKAP----------------- 717
                                        .|..:.|..|..|.::.|.|
Worm  1252 QDWSAQNNQQQEEDDGSEYGSDNGELLQTDEDYEERRRRREERSEKLPPLLAKVNGQIEVLGFNP 1316

  Fly   718 --------------RPPK--------------------------------QPIVQDFQFF---PP 733
                          .||:                                :|:|.:...|   .|
Worm  1317 RQRKAFYNAVMRWGMPPQDLTQSSWQVRDLRNKSEKVFKAYSSLFMRHLCEPVVDNSDSFMDGVP 1381

  Fly   734 R-------------LFELLDQEIYYFRKTVG-YKVPKNTE--LGSDA----------TKVQRE-- 770
            |             |..:|.:::..|.|..| :.:|:..|  |.:.|          .|::.|
Worm  1382 REGLNRQAVLSRIGLMSILRKKVQEFEKFNGEWSMPETREKMLATAAQASVSNLPGMIKIKEEPI 1446

  Fly   771 ---------EQRKIDEAEPLTEEEIQEKE----------NLLSQGFTAWTKRDFNQFIKANEKYG 816
                     :|..|.:.|.|..|...|:|          |:...|:|.......|:     ||..
Worm  1447 DIDETPMDVDQSNITKTEELASEVKVEEEPKAPRLPYKFNICDGGYTELHSLWINE-----EKVA 1506

  Fly   817 RDDIDNIAKDVEGKTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKAL-DQKM 880
            |:          ||      ||.  .|.|   ..|...:......|.|:.|  ::.:..: |.|.
Worm  1507 RN----------GK------EYE--IWHR---RHDFWLLAAVAVYGYGRYQ--INFQDIMNDPKF 1548

  Fly   881 SRYRAPFHQLRLQYGNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQ 937
            |....||.|.    |.:...|:.:::::|| ....||......:.|:||.|...:.|
Worm  1549 SIVNEPFKQT----GADPATNFADVKNKFL-ARRFKLLEQSLVIEEQLRRAAHINKQ 1600

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.