Protein Alignment Iswi and let-418

DIOPT Version :10

• Sequence 1: NP_523719.1
• Gene: Iswi / 36390
• FlyBaseID: FBgn0011604
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_504523.1
• Gene: let-418 / 178970
• WormBaseID: WBGene00002637
• Length: 1829
• Species: Caenorhabditis elegans
• Alignment Length: 1012
• Identity: 322/1012 - (31%)
• Similarity: 491/1012 - (48%)
• Gaps: 173/1012 - (17%)

  Fly    74 RPKKIKD---KDKEKDVADHRHRK-TEQEEDEELLAEDSATKEIFRFDASPAYI--KSGEMRDYQ 132
            |..|:.:   |:.:|.:|.||..| ...:|||:...:........:::..|.|:  ..|::..||
 Worm   542 RESKLNEDIPKNVQKMIAKHREAKGLPPKEDEKKKKKREKIDIRKKYEVQPDYVTETGGKLHPYQ 606

  Fly   133 IRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFK 197
            :.||||:...:.||.:.|||||||||||:|:::.|..|....:..||.::..|.||:.||..|.:
 Worm   607 LEGLNWLRHCWSNGTDAILADEMGLGKTVQSLTFLYSLMKEGHCKGPFLIAAPLSTIINWEREAE 671

  Fly   198 KWCPSLRAVCLIGDQDTR-------NTFIRDVLMPG------------EWDVCVTSYEMCIREKS 243
            :|||....|..:|.:|.|       .:|:...:..|            ::.|.:||||....:|:
 Worm   672 QWCPDFYVVTYVGLRDARVVLREHEFSFVEGAVRSGPKASKMKTTENMKFHVLLTSYETINMDKT 736

  Fly   244 VFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFN 308
            :.....|..||:|||||:||.:|...:.|.|:....|:|:|||||||||.||:.|||||..:.||
 Worm   737 ILSSIEWGALVVDEAHRLKNNQSLFFKNLNEYTIHYRVLLTGTPLQNNLEELFHLLNFLSKERFN 801

  Fly   309 SSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYT 373
            ..|.|...||.   :..:..|.:||.:|.|.:||||||:|...:..|.|:.:.|.||.||:.||.
 Worm   802 QLEAFTAEFNE---ISKEDQIEKLHNLLGPHMLRRLKADVLTGMPSKSELIVRVELSAMQKKWYK 863

  Fly   374 KVLLKDIDVVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTD-----THLVYNSGKM 433
            .:|.::.|.:|......:|.|.|:||:|:||.||||||..||...|...:     |.|:.||||.
 Worm   864 NILTRNFDALNVKNGGTQMSLMNVLMELKKCCNHPYLFVKAELEAPKEKNGMYEGTALIKNSGKF 928

  Fly   434 AILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNS 498
            .:|.|:|.||::.|.||||||||||||||:||.|.:..|.|.|:||....:.|...|..:|...:
 Worm   929 VLLQKMLRKLKDGGHRVLIFSQMTRMLDIMEDLCEYEGYRYERIDGSIMGQMRQDAIDRYNAPGA 993

  Fly   499 AKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEE 563
            .:|:|:||||||||||||||||.||||||||||..|:||..||||:|||.:|.::|.:|:.:|||
 Worm   994 QQFIFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRLGQKHKVMIYRFVTKKSVEE 1058

  Fly   564 KIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDVILER 628
            ||...|:.|:.|:.:|::.| |.......::|.|:.:::|:|..::||        ||:|.....
 Worm  1059 KITSVAKKKMLLNHLVVRAG-LGGKEGKTMSKTELDDVLRWGTEELFS--------EDLDAAEGE 1114

  Fly   629 GEAK--TAEQK-----AALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIE 686
            |..|  .|.|:     ||:|:|         :|.:.:..|.:     |||..||      ..|
 Worm  1115 GSEKKGAAAQEIVWDDAAVDAL---------LDRSNKEETPA-----GEDGEEK------AEW-- 1157

  Fly   687 PPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFP-PRLFELLDQEIYYFRKTV 750
              :.|..:::.|.:|     :..|.:..:.....:..::::.:..| |..:|.|.:..|
 Worm  1158 --QNEYLSSFKVASY-----QTKETEGQEEEEEEETEVIKEDEKEPDPDYWEKLLKHHY------ 1209

  Fly   751 GYKVPKNTELGSDATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGF-TAWTKRDFNQ-FIKANE 813
                               |:.|:|:..:....:.::::.|..|:.. |.|:|::..| ....||
 Worm  1210 -------------------EQDREIELQKLGKGKRVRKQINYASENMGTDWSKQNQTQDDDDDNE 1255

  Fly   814 KY-GRDDIDNIAKDVEGKTPEEVIEYNAVFWERCTELQDIE-------RIMGQIE-RGEGKIQRR 869
            .| |.|:.|.:..|.:        :|:    |:....:|.|       ::.||:| .|....||
 Worm  1256 SYRGSDNGDGLNSDED--------DYD----EKKKRRRDEEKMPPLMAKVNGQVEILGFNPRQR- 1307

  Fly   870 LSIKKALDQKMSRYRAP---FHQ---LRLQYGNNKGKNYTEIEDRFL--VCMLHKLGFDKENVYE 926
                ||....:.|:..|   .||   |.....|...|.:......|:  :|   :.|.|..:.:.
 Worm  1308 ----KAFYGAVMRWGMPPQDSHQSQWLVRDLRNKSEKVFRAYASLFMRHLC---EPGADGHDTFN 1365

  Fly   927 ELRAAIRASPQFRFDWFIKSRTALELQRRCNT--LITLIERENIELEE--------KERAEKKKK 981
            :      ..|          |..|..|.....  |::|:.|:..|.|:        :.:.|...|
 Worm  1366 D------GVP----------REGLNRQHVLGRIGLLSLVRRKVQEFEQYNGQWSMPEIQDEVLAK 1414

  Fly   982 APKGSVSAGSGSASSNTPAPAPQPKASQKRKSEVVAT 1018
            |..||....|.|    ||.|..:||.....|.:...|
 Worm  1415 AANGSAQGSSRS----TPKPKEEPKEEPMEKEDATET 1447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	PLN03142	46..967	CDD:215601	306/951 (32%)
let-418	NP_504523.1	CHDNT	95..147	CDD:462357
		PHD1_CHD_II	258..300	CDD:277006
		RanBP2-type Zn finger	295..323	CDD:275375
		PHD_SF	320..362	CDD:473978
		CD1_tandem_CHD3-4_like	370..448	CDD:349314
		CD2_tandem_CHD3-4_like	486..539	CDD:349309
		PLN03142	590..>1114	CDD:215601	224/535 (42%)
		DUF1087	1188..1235	CDD:461922	9/71 (13%)
		CHDII_SANT-like	1276..1406	CDD:461920	30/153 (20%)
		CHDCT2	1525..1673	CDD:462358