DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and isw-1

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001379931.1	Gene:	isw-1 / 175944	WormBaseID:	WBGene00002169	Length:	1009	Species:	Caenorhabditis elegans

Alignment Length:	1028	Identity:	626/1028 - (60%)
Similarity:	788/1028 - (76%)	Gaps:	48/1028 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ATEENSNE-------TTSDAATSSSGEKEAEFDNKIE----ADRSRRFDFLLKQTEIFTHFMTN- 63
            :..|:|||       |.|:...||..:...|.|::.|    ||..:||:.||::||.|:|.:::
Worm     2 SVHESSNEINDEPMDTDSNIPESSGNDPSMEVDDEPESSDAADSFKRFERLLQKTENFSHCLSSG 66

  Fly    64 ------SAKSPTKPKGRPKKIKDKDKEKDVADHRHRKTEQEEDEELLAEDSATKEIFRFDASPAY 122
                  .|...||.:|||.|....|     .||||||||||||||::|:...:.::..||.||.|
Worm    67 DAKLATGAPVDTKKRGRPSKKNGID-----GDHRHRKTEQEEDEEMVADAIKSDDLVIFDKSPFY 126

  Fly   123 IKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKS 187
            |::|||||||:|||||:.||..|.|||||||||||||||||||::||:||:||:|.||:||||||
Worm   127 IENGEMRDYQVRGLNWLASLQHNKINGILADEMGLGKTLQTISMIGYMKHYKNKASPHLVIVPKS 191

  Fly   188 TLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRY 252
            |||||.|||||||||:.||.||||:..||..:|||::|.::|||.|:|||.::.|:..||.||||
Worm   192 TLQNWANEFKKWCPSINAVVLIGDEAARNQVLRDVILPQKFDVCCTTYEMMLKVKTQLKKLNWRY 256

  Fly   253 LVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWF 317
            ::||||||||||||||||.:||..:.|||||||||||||||||||||||||||:|.||:|||.||
Worm   257 IIIDEAHRIKNEKSKLSETVRELNSENRLLITGTPLQNNLHELWALLNFLLPDIFTSSDDFDSWF 321

  Fly   318 NTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDV 382
            :.:...|:..|:.|||.||:||||||:|::|||.|.||||:|::||||||||:||||||:||||:
Worm   322 SNDAMSGNTDLVQRLHKVLQPFLLRRIKSDVEKSLLPKKEVKVYVGLSKMQREWYTKVLMKDIDI 386

  Fly   383 VNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQG 447
            :||||||||.||.||||.||||.||||||||||||||:|||.|||.|||||.:|||||.|.:|||
Worm   387 INGAGKVEKARLMNILMHLRKCVNHPYLFDGAEPGPPFTTDQHLVDNSGKMVVLDKLLMKFKEQG 451

  Fly   448 SRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGL 512
            ||||||||.:||||:|||:|.||:|.||||||.||||||:..|:.:|..:|.||:|||:||||||
Worm   452 SRVLIFSQFSRMLDLLEDFCWWRHYEYCRLDGSTPHEDRSNAIEAYNAPDSKKFIFMLTTRAGGL 516

  Fly   513 GINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDK 577
            ||||||||||||||||||||.|||||||||||||||||||||||||:||:|:|:|:||.|||||.
Worm   517 GINLATADVVIIYDSDWNPQSDLQAMDRAHRIGQKKQVRVFRLITENTVDERIIEKAEAKLRLDN 581

  Fly   578 MVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDVILERGEAKTAEQKAALDS 642
            :|||.||:.:.:.. |.|.:|:::||.||.|||::|::.|:|:|||.|||:.|.||||....:..
Worm   582 IVIQQGRMSEAQKT-LGKGDMISMIRHGAEQVFAAKDSTISDDDIDTILEKAEVKTAELNEKMGK 645

  Fly   643 LGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGN-WIEPPKRERKANYAVDAYFREAL 706
            :.|::||..|.:.|.:   .:|||||||:::.|| .:.:|: |||||||||||||.||.|::||:
Worm   646 IDENNLRNMTFEDNAK---FTVYQFEGENYKAKQ-ADGMGHFWIEPPKRERKANYQVDLYYKEAM 706

  Fly   707 RVSEP--KAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGY--KVPKNTELGSDATKV 767
            |...|  |..|||| ||.|.|.||||:|.|||||||:|||::|||:||  :.||:.. ..:|.|.
Worm   707 RAGNPTEKQSKAPR-PKLPQVFDFQFYPRRLFELLDKEIYHYRKTIGYVAERPKDVP-PKEAEKR 769

  Fly   768 QREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNIAKDVEGKTP 832
            |.|||:.|:.|.|||::|.:||..||:|..|.||||:|.||::.||||||:|:::|||::| :..
Worm   770 QAEEQKLINNARPLTDKEQEEKAELLTQSVTDWTKREFQQFVRGNEKYGREDLESIAKEME-RPL 833

  Fly   833 EEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFHQLRLQYGNN 897
            ||:..|..|||||..||||.|:::.|||:||.:|||:.::|||||.|:::|:|||.|||:.||.|
Worm   834 EEIQSYAKVFWERIEELQDSEKVLSQIEKGEARIQRKYAVKKALDAKIAKYKAPFQQLRISYGTN 898

  Fly   898 KGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQRRCNTLITL 962
            |||.|||.|||||||..|:||.|||||:||||.::|.:||||||||:|||||:||||||||||||
Worm   899 KGKTYTEEEDRFLVCETHRLGHDKENVFEELRQSVRMAPQFRFDWFLKSRTAMELQRRCNTLITL 963

  Fly   963 IERENIELEEKE-----RAEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQK 1010
            ||||..|:.|.:     .|:|||...|..      |.||.||. |.:.||:.|
Worm   964 IEREMGEVVESKPVIVTAADKKKSVAKDL------SKSSGTPT-AKKVKATPK 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	14/47 (30%)
		SNF2_N	131..411	CDD:278600	200/279 (72%)
		DEXDc	148..287	CDD:238005	98/138 (71%)
		HELICc	422..553	CDD:238034	102/130 (78%)
		HAND	697..796	CDD:286232	54/102 (53%)
		SANT	797..838	CDD:197842	21/40 (53%)
		SANT	799..838	CDD:238096	20/38 (53%)
		SLIDE	853..965	CDD:286233	77/111 (69%)
isw-1	NP_001379931.1	PLN03142	48..1008	CDD:215601	612/979 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165763
Domainoid	1	1.000	422	1.000	Domainoid score	I317
eggNOG	1	0.900	-	-		E2759_KOG0385
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55711
Inparanoid	1	1.050	1237	1.000	Inparanoid score	I87
Isobase	1	0.950	-	0	Normalized mean entropy	S3
OMA	1	1.010	-	-		QHG54891
OrthoDB	1	1.010	-	-		D144251at33208
OrthoFinder	1	1.000	-	-		FOG0001113
OrthoInspector	1	1.000	-	-		oto18908
orthoMCL	1	0.900	-	-		OOG6_100877
Panther	1	1.100	-	-	LDO	PTHR10799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2588
SonicParanoid	1	1.000	-	-		X1240
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750