Protein Alignment Iswi and Smarca4

DIOPT Version :9

• Sequence 1: NP_523719.1
• Gene: Iswi / 36390
• FlyBaseID: FBgn0011604
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_006242658.1
• Gene: Smarca4 / 171379
• RGDID: 621728
• Length: 1650
• Species: Rattus norvegicus
• Alignment Length: 1107
• Identity: 352/1107 - (31%)
• Similarity: 516/1107 - (46%)
• Gaps: 265/1107 - (23%)

  Fly    21 SDAATSSSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHFMTNSAKSPTKPKGRPKKIKDKDKEK 85
            ||:..|.|.|:|.|.:.:                      ....|:.||.|....|||.|.|.:
  Rat   655 SDSEESGSEEEEEEEEEE----------------------QPQPAQPPTLPVEEKKKIPDPDSD- 696

  Fly    86 DVA--DHRH--RKTEQEEDEELLAEDSATKEI-----------FRFDASPAYIKSGEMRDYQIRG 135
            ||:  |.||  ...:|:.|:|.....:..:.:           .|.|...|.:.:|.::.|||:|
  Rat   697 DVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKG 761

  Fly   136 LNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKWC 200
            |.|::|||.|.:|||||||||||||:|||:|:.||...|...||.::|||.|||.||..||.||.
  Rat   762 LEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWA 826

  Fly   201 PSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRYLVIDEAHRIKNEK 265
            ||:..|...|....|..|:.. |..|:::|.:|:||..|::|.:..|..|:|:::||.||:||..
  Rat   827 PSVVKVSYKGSPAARRAFVPQ-LRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHH 890

  Fly   266 SKLSEILR-EFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFNTNTCLGDD--- 326
            .||:::|. .:....|||:|||||||.|.|||||||||||.:|.|...|::|||....:..:
  Rat   891 CKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVD 955

  Fly   327 -------ALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVVN 384
                   .:|.|||.||:||||||||.|||.:|..|.|..|...:|.:||..|..:..|.:.:.:
  Rat   956 LNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTD 1020

  Fly   385 GAGKVEKMR-----LQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYN------------SGK 432
            |:.|.:|.:     |.|.:|||||..||||:|...|.    :...||.:.            |||
  Rat  1021 GSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEE----SFSEHLGFTGGIVQGLDLYRASGK 1081

  Fly   433 MAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDN 497
            ..:||::||||:....:||:|.|||.::.|:|||..:|.:.|.||||.|..|||...::.||...
  Rat  1082 FELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPG 1146

  Fly   498 SAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVE 562
            |..|:|:|||||||||:||.:||.|||:||||||..||||.||||||||:.:|||.||.|.::||
  Rat  1147 SEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVE 1211

  Fly   563 EKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDVILE 627
            |||:..|:.||.:|:.|||.| :.|.:|:...:...|                       ..|||
  Rat  1212 EKILAAAKYKLNVDQKVIQAG-MFDQKSSSHERRAFL-----------------------QAILE 1252

  Fly   628 RGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPKRE- 691
            ..|    :.::...|.|..| .:|.......||.:...:                   |||.:|
  Rat  1253 HEE----QDESRHCSTGSGS-ASFAHTAPPPAGVNPDLE-------------------EPPLKEE 1293

  Fly   692 ------RKANYAVDAYFRE---ALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFR 747
                  ...|..:..:..|   .:|:...:..:..|.||:         .|||.|
  Rat  1294 DEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKR---------KPRLME---------- 1339

  Fly   748 KTVGYKVPKNTELGS----DATKVQR----EEQRK-----------IDEAEPLTE---------- 783
                     ..||.|    |..:|:|    ||:.|           :|.::.|||
  Rat  1340 ---------EDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKTLKAI 1395

  Fly   784 -----EEIQEK--------------ENLLSQGFTAWTKRDFNQFIKANEKYGRDDID-------N 822
                 |||:|:              |...|...|:...||.::..|..:|.||...:       |
  Rat  1396 EEGTLEEIEEEVRQKKSSRKRKRDSEAGSSTPTTSTRSRDKDEESKKQKKRGRPPAEKLSPNPPN 1460

  Fly   823 IAKDVEGKTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAP- 886
            :.|.:: |..:.||:|.             :...|: :..|..||  |..:|.|.:.....|.|
  Rat  1461 LTKKMK-KIVDAVIKYK-------------DSSSGR-QLSEVFIQ--LPSRKELPEYYELIRKPV 1508

  Fly   887 -FHQLRLQYGNNKGKNYTEIE-DRFLVCMLHKLGFDKEN--VYEELRAAIRASPQFRFDWFIKSR 947
             |.:::.:..|:|.::..::| |..|:|. :...|:.|.  :||:
  Rat  1509 DFKKIKERIRNHKYRSLNDLEKDVMLLCQ-NAQTFNLEGSLIYED-------------------- 1552

  Fly   948 TALELQRRCNTLITLIERENIELEEKERAEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQKRK 1012
             ::.||    ::.|.: |:.||.|:....|:.::..:|. ..||.|.|.:...   :.|..:|.|
  Rat  1553 -SIVLQ----SVFTSV-RQKIEKEDDSEGEESEEEEEGE-EEGSESESRSVKV---KIKLGRKEK 1607

  Fly  1013 SE 1014
            ::
  Rat  1608 AQ 1609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	4/36 (11%)
		SNF2_N	131..411	CDD:278600	138/295 (47%)
		DEXDc	148..287	CDD:238005	65/139 (47%)
		HELICc	422..553	CDD:238034	72/142 (51%)
		HAND	697..796	CDD:286232	28/149 (19%)
		SANT	797..838	CDD:197842	12/47 (26%)
		SANT	799..838	CDD:238096	11/45 (24%)
		SLIDE	853..965	CDD:286233	23/116 (20%)
Smarca4	XP_006242658.1	Med15	42..>217	CDD:312941
		QLQ	171..205	CDD:400990
		Smc	<370..>570	CDD:224117
		HSA	460..532	CDD:214727
		BRK	612..654	CDD:400080
		DEXHc_SMARCA4	731..981	CDD:350820	114/250 (46%)
		PLN03142	750..>1232	CDD:215601	229/486 (47%)
		SnAC	1323..1389	CDD:405324	20/93 (22%)
		Bromo_SNF2L2	1461..1567	CDD:99947	29/149 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910