DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and Hells

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_032260.2	Gene:	Hells / 15201	MGIID:	106209	Length:	821	Species:	Mus musculus

Alignment Length:	815	Identity:	283/815 - (34%)
Similarity:	415/815 - (50%)	Gaps:	174/815 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TAAVEATEENSNETTSDAATSSSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHFM--------- 61
            |.|:...||.......:.......|.:..:|.:....|.||...||:::.|::.|:
Mouse    11 TPAMLEEEEQLEAAGLEKERKMLEEAQKSWDRESTEIRYRRLQHLLEKSNIYSKFLLTKMEQQQL 75

  Fly    62 -TNSAKSPTKPKGRP------KKIKDKDKEKDV-------ADHRHRKTEQEEDEELLA------- 105
             ....|...:.|.|.      |.:.|.:.||.|       .|..:..:|....||:|:
Mouse    76 EEQKKKEKLEKKKRSLKLTEGKSLVDGNGEKPVMKKKRGREDESYNISEVMSKEEILSVAKKHKD 140

  Fly   106 ---EDSATKEI----------------------------FRFD------------ASPAYIKSGE 127
               |.|:|..:                            |.||            ..|.:...|.
Mouse   141 NEDESSSTTSLCVEDIQKNKDSNSMIKDRLSQTVRQNSKFFFDPVRKCNGQPVPFQQPKHFTGGV 205

  Fly   128 MRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNW 192
            ||.||:.|:.|:..|:|||||||||||||||||:|.|:.:..:.. :...||.:|..|.|||.||
Mouse   206 MRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQ-RGVPGPFLVCGPLSTLPNW 269

  Fly   193 VNEFKKWCPSLRAVCLIGDQDTRNTFIRDV--------LMPGEWDVCVTSYEMCIREKSVFKKFN 249
            :.|||::.|.:..:...|.::.|...::::        :.|    |.|||:|:.:|:::..:...
Mouse   270 MAEFKRFTPEIPTLLYHGTREDRRKLVKNIHKRQGTLQIHP----VVVTSFEIAMRDQNALQHCY 330

  Fly   250 WRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFD 314
            |:||::||.|||||.|.:|...|:.|...|:||:|||||||||.|||:||||||||||:..:.|:
Mouse   331 WKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFE 395

  Fly   315 EWFNTNTCLGDDA-----------LITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQ 368
            .||:. |.|.:.|           ::..||.:|.||||||||::|...:.||:|:.::..|...|
Mouse   396 SWFDI-TSLSETAEDIIAKEREQNVLHMLHQILTPFLLRRLKSDVALEVPPKREVVVYAPLCNKQ 459

  Fly   369 RDWYTKVLLKDI----------------------------------------------------- 380
            ..:||.::.:.|
Mouse   460 EIFYTAIVNRTIANMFGSCEKETVELSPTGRPKRRSRKSINYSELDQFPSELEKLISQIQPEVNR 524

  Fly   381 --DVVNGAGKVE---KMRLQNILMQLRKCTNHPYLFDGAEPGPPYT----TDTHLVYNSGKMAIL 436
              .||.|...:|   .::|:||:|.||||.||||:.:  .|..|.|    .|..||.||||..||
Mouse   525 ERTVVEGNIPIESEVNLKLRNIMMLLRKCCNHPYMIE--YPIDPVTQEFKIDEELVTNSGKFLIL 587

  Fly   437 DKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKF 501
            |::||:|:::|.:||:|||||.|||||.||||.||:.:.||||...:.:|.:.|..||.|... |
Mouse   588 DRMLPELKKRGHKVLVFSQMTSMLDILMDYCHLRNFIFSRLDGSMSYSEREKNIYSFNTDPDV-F 651

  Fly   502 LFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIV 566
            ||::|||||||||||..||.|||||||||||.||||.||.|||||.|.|.|:||:|.:|:::|||
Mouse   652 LFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIV 716

  Fly   567 ERAEVKLRLDKMVI-----QGGRL-VDNRSNQLNKDEMLNII--RFGANQVFSSKETDITDEDID 623
            |||..|.:|:|::|     :||:. :....|.|:..|::.::  |....:|..|:|..|:|||::
Mouse   717 ERAAAKRKLEKLIIHKNHFKGGQSGLSQSKNFLDAKELMELLKSRDYEREVKGSREKVISDEDLE 781

  Fly   624 VILERGEAKTAEQKAALDSLGESSLRTFTMDTNGE 658
            ::|:|.:. ..:.||:....|::.:  |.:..|.|
Mouse   782 LLLDRSDL-IDQMKASRPIKGKTGI--FKILENSE 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	9/46 (20%)
		SNF2_N	131..411	CDD:278600	127/356 (36%)
		DEXDc	148..287	CDD:238005	56/146 (38%)
		HELICc	422..553	CDD:238034	81/130 (62%)
		HAND	697..796	CDD:286232
		SANT	797..838	CDD:197842
		SANT	799..838	CDD:238096
		SLIDE	853..965	CDD:286233
Hells	NP_032260.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..120		9/41 (22%)
		DEXHc_HELLS_SMARCA6	203..436	CDD:350767	103/238 (43%)
		PLN03142	204..>781	CDD:215601	242/585 (41%)
		helicase domain I	226..238		11/11 (100%)
		helicase domain Ia	258..266		3/7 (43%)
		helicase domain II	334..341		3/6 (50%)
		helicase domain III	363..370		5/6 (83%)
		helicase domain IV	429..439		8/9 (89%)
		helicase domain IVa	547..559		8/11 (73%)
		'helicase domain IVb	602..609		5/6 (83%)
		helicase domain V	655..668		11/12 (92%)
		helicase domain VI	686..693		4/6 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0385
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	1	1.000	-	-		FOG0001113
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820