DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and hells

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001135693.1	Gene:	hells / 100216265	XenbaseID:	XB-GENE-5883772	Length:	840	Species:	Xenopus tropicalis

Alignment Length:	812	Identity:	281/812 - (34%)
Similarity:	422/812 - (51%)	Gaps:	190/812 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EKEAEFDNKIEADRSR-------------RFDFLLKQTEIFTHF-MTNSAKSPTKPKGRPKKIKD 80
            ||.||.:.:...:::|             |...||:::.|::.| :|...:...:...|.:|::.
Frog    40 EKAAEVEERKMIEKARMSWERDSNEMRYKRLQHLLEKSNIYSKFLLTKMEQQQLEEMRRKEKLEK 104

  Fly    81 KDKEKDVADHRH-----------RKTEQEED----------EELLA---------EDS------A 109
            |.|..:....::           ||..|.|:          ||:|:         ||:      .
Frog   105 KQKRTESLKTQNQSSANEDNTGGRKKRQREENYHISDVMSKEEILSVSKKSKLEHEDTNYSSKLT 169

  Fly   110 TKEIFRFDAS-----------------------------------PAYIKSGEMRDYQIRGLNWM 139
            ::||.:...|                                   |.|...|.||.|||.|:.|:
Frog   170 SEEIEKNGDSNSTIKDRLSQTVRNNTKQLLDPERKVNGQPVPFQQPKYFTGGVMRWYQIEGMEWL 234

  Fly   140 ISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLR 204
            ..|:|||||||||||||||||:|.|:.:..:.. :...||..|..|.|||.|||:|||::.|.:.
Frog   235 RMLWENGINGILADEMGLGKTVQCIATISMMVE-RGVPGPFFVCGPLSTLPNWVSEFKRFSPEVP 298

  Fly   205 AVCLIGDQDTRNTFIRDV--------LMPGEWDVCVTSYEMCIREKSVFKKFNWRYLVIDEAHRI 261
            .:...|:...|....|.:        :.|    |.:||:|:.:|::.:.:...|:|:::||.|||
Frog   299 VLLYHGNAQERRRLARKINKREGSLQIYP----VVITSFEIAMRDRQILQHSPWKYMILDEGHRI 359

  Fly   262 KNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFNTNTCLGDD 326
            ||...:|.:.|::|::.|:||:|||||||||.|||:||||||||||:....|:.||:. |.:..:
Frog   360 KNMNCRLIQELKQFRSDNKLLLTGTPLQNNLAELWSLLNFLLPDVFDDLRSFESWFDI-TGISQN 423

  Fly   327 A-----------LITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDI 380
            |           ::..||.:|.||||||||.:|...:.||:|:.::..|:|.|..:||.::.|.|
Frog   424 AEDIVANEREQNILHMLHQILTPFLLRRLKCDVTLEVPPKREVVVYAPLTKKQETFYTAIVNKTI 488

  Fly   381 DVVNGAGK-----------------------------------------------VEK------- 391
            :.:.|..|                                               |||
Frog   489 EKMLGQEKEHVKIISSPAVGRAKRRSRKAVNYSELDKDTPNDLEKLINQLLKQQEVEKERPSAKA 553

  Fly   392 ---------MRLQNILMQLRKCTNHPYLFDGAEPGPPYT----TDTHLVYNSGKMAILDKLLPKL 443
                     ::::||:|.||||.|||||.:  .|..|.|    .|..||.:|||..:||:|||::
Frog   554 DLPLDSEVNLKMRNIMMLLRKCCNHPYLIE--YPLDPLTQDFKIDEELVNSSGKFLLLDRLLPEM 616

  Fly   444 QEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTR 508
            :::|.:||||||||.|||||.|||:::.:|:|||||...:.||...:::||.:... |:|::|||
Frog   617 KKRGHKVLIFSQMTMMLDILMDYCYYKKFNFCRLDGSMSYSDREENMRKFNTEPDV-FIFLVSTR 680

  Fly   509 AGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKL 573
            ||||||||..||.|||||||||||.||||.||.|||||.:.|.|:||:|.:|:::||||||..|.
Frog   681 AGGLGINLTAADTVIIYDSDWNPQADLQAQDRCHRIGQTRPVVVYRLVTANTIDQKIVERAAAKR 745

  Fly   574 RLDKMVI-----QGGRLVDNRSNQ-LNKDEMLNII--RFGANQVFSSKETDITDEDIDVILERGE 630
            :|:|:||     :||:...|:|.. |:..|:|.::  |....:|..|.|..|:|:|::::|:|.:
Frog   746 KLEKLVIHKNKFKGGQTGINQSKSCLDPKELLELLQSRDYEREVKGSSEKVISDKDLELLLDRSD 810

  Fly   631 AKTAEQKAALDSLGESSLRTFTMDTNGEAGTS 662
            . .|:.|..: ||.:|....|.:..|.|...|
Frog   811 L-VAQMKNNV-SLQKSKQGVFKVVDNTEVTES 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	11/50 (22%)
		SNF2_N	131..411	CDD:278600	128/361 (35%)
		DEXDc	148..287	CDD:238005	55/146 (38%)
		HELICc	422..553	CDD:238034	76/130 (58%)
		HAND	697..796	CDD:286232
		SANT	797..838	CDD:197842
		SANT	799..838	CDD:238096
		SLIDE	853..965	CDD:286233
hells	NP_001135693.1	PLN03142	81..>816	CDD:215601	264/744 (35%)
hells	NP_001135693.1	DEXHc_HELLS_SMARCA6	220..453	CDD:350767	102/238 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	1	1.000	-	-		FOG0001113
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920