Protein Alignment Iswi and ercc6l2

DIOPT Version :10

• Sequence 1: NP_523719.1
• Gene: Iswi / 36390
• FlyBaseID: FBgn0011604
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_001362231.1
• Gene: ercc6l2 / 100127871
• XenbaseID: XB-GENE-952480
• Length: 1397
• Species: Xenopus tropicalis
• Alignment Length: 1158
• Identity: 281/1158 - (24%)
• Similarity: 469/1158 - (40%)
• Gaps: 304/1158 - (26%)

  Fly    76 KKIKDKDKEKDVADHRHRKTEQEEDEELLAEDSATKEIFRFDASP----------------AYIK 124
            ||:...:.:|..:.:....|...:||:|       ::.|..|..|                .|..
 Frog    55 KKVPLSEIQKPPSYNSSWNTSMFDDEDL-------EKPFFPDRRPHGPLENFPLSNTAVSVPYTI 112

  Fly   125 SGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTIS----------------------LL 167
            :..:||||..|:.::...:...:..||.|:||||||:|.|:                      ||
 Frog   113 NRYLRDYQRDGITFLYKHFSRSVGCILGDDMGLGKTIQVIAFLAAILGKKGTREDIENNMPEFLL 177

  Fly   168 GYLKHFKNQAGP---HIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGD-QDTRNTFIRDVLMPGEW 228
            ..:|...:.:.|   .:::.|.|.|.||.:|.:.| ...|...:.|: :|:..:.::.    |::
 Frog   178 RTVKKVCSSSSPKKVFLIVSPLSVLYNWKDELETW-GYFRLTLIHGNKKDSEISRLKQ----GKF 237

  Fly   229 DVCVTSYE---MCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQN 290
            ::.:|:||   :|:.|   ....:|..:|:||.|||||.|::::::::|.:...|:.:|||.|||
 Frog   238 EIALTTYETLRLCLDE---INSIDWSAVVVDEVHRIKNPKARVTQVMKEIRCKVRIGLTGTILQN 299

  Fly   291 NLHELWALLNFLLPDVFNSSEDFDEWFNT-------------NTCLGDDALITRLHAVLKPFLLR 342
            |:.|||.::::.:|....||..|.|.|:.             ....|..|:.| |...|.||.||
 Frog   300 NMEELWCVMDWAVPGYLGSSSQFKEKFSNPVEYGQRHNATKRELATGRKAIQT-LANKLSPFFLR 363

  Fly   343 RLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVL-LKDIDVVNGAGK---------------VEK 391
            |.||.:.::|..|::..||..||:.|:..|..|| .:|:::|...|:               .|.
 Frog   364 RTKALISQQLPKKEDRIIFCSLSEFQKAVYQTVLETQDVNLVLQGGEPCSCKSGRKRRKCCYKEN 428

  Fly   392 MRLQNI-------LMQLRKCTNHPYLFDGAEPGPPYTTDT--------HL------VYN------ 429
            |..:::       |..|||..||..|..         |||        |:      |::
 Frog   429 MFGESVRTLYFSYLAILRKVANHAALLQ---------TDTSTSKKQEAHIKRVCNEVFSKFPEFV 484

  Fly   430 ----------------SGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLD 478
                            ||||.:|.:||...::...:||:||..|::||:||.|......:|.|||
 Frog   485 RQSKDAAFETLSNPRYSGKMKVLQQLLNHCRKNKDKVLLFSFSTKLLDVLERYSMASGLDYRRLD 549

  Fly   479 GQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHR 543
            |.|..|:|.:.::|||...... :.::||.|||||:|...|:||:::|..|||..||||:|||:|
 Frog   550 GNTKAEERMKIVKEFNTMQDVN-ICLVSTMAGGLGLNFIGANVVVVFDPTWNPANDLQAIDRAYR 613

  Fly   544 IGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVIQGGRLVDN--------RSNQLNKDEMLN 600
            |||.:.|:|||.::..||||.|..|...|.:|...|:..    :|        :.::.:|.|:
 Frog   614 IGQCRDVKVFRFVSLGTVEEMIYLRQVYKQQLQCAVVGS----ENAKRYFEAVQGSKEHKGEL-- 672

  Fly   601 IIRFGANQVFSSK-ETDITDEDIDVILERGEAKTAEQKAALDSLGESSL----RTFTMDTNGEAG 660
               ||.|.:|..: :......|   ||||       :|...|.:..:|:    ...|:||...|.
 Frog   673 ---FGVNNLFKLRPQGSCLTRD---ILER-------EKQVEDGVTSASMYVSQTPVTVDTEMGAD 724

  Fly   661 TSSVYQFEGEDWREKQKLNALGNWIEPPKRERKANYAVDAYFREAL------RVSEPKAPKAPRP 719
            ..|                      :.||...|   ....:|:|:.      ...|.......:|
 Frog   725 IDS----------------------DDPKVGAK---HCQRFFKESTFDFSSDSDEETNGTSVMKP 764

  Fly   720 PKQPIVQD-------FQFFPPRLFELLDQEIYYFRKTVGYKVPKNTEL-------GSDATKVQRE 770
            .|.|...|       .|:   ...::|::||....|........||.:       |..:::...|
 Frog   765 SKMPSNSDNRRQLTLHQY---GFSKMLEREITTDNKKTSLPGESNTSILNVNMSSGKKSSRTVLE 826

  Fly   771 EQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNIAKDVEGKTPEEV 835
            .:..:.|.|..::|  ..::.:||   |...|:|..:.|...:.....|..:|..|....|..:.
 Frog   827 NENVVSETEYSSDE--SGEDIVLS---TQVCKQDKGKKISIIKCIAESDSSDIDLDTSDNTNRQP 886

  Fly   836 IEYNAVFWERCTELQDIERIMGQIERGE-GKIQ------------------------RRLSIKKA 875
            :  |:...:...|..||| |..:...|. ||::                        ..|.|||:
 Frog   887 V--NSSCDDISDESDDIE-IPNKYRSGNTGKLKDSFNNKYDAAKDSQTIEVFTSSDDDNLQIKKS 948

  Fly   876 ------LDQKMSRYR------------------APFHQLRLQY-GNNKGKNYTEIED-RFLVCML 914
                  ..||.|..|                  |..||..::| |::..|....:|. .::....
 Frog   949 SPSYEDTPQKSSNLRMHMESRKRKNKSVFQIKKAITHQEGVKYNGSSLDKVLDGVEGVAYIHSNQ 1013

  Fly   915 HKLGFDK-ENVYEELRAAIRASPQFR-FDWFIKSRTALELQRR--CNTLITLIERENIELEEKER 975
            |.:|..| ||  :..|.|:|...:.: |.....:.|.|::.:.  .:..:|.:.:...:||.|..
 Frog  1014 HVVGSSKAEN--QLSRWAVRDVFELKQFSQLPANITPLKITKSEYVSDKMTPLRKTEKDLETKSY 1076

  Fly   976 -------AEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQKRKSEVVATSSN 1021
                   ..::||..:         ....|......|||.|:::.:.:|...|
 Frog  1077 PMLQYPVTHQQKKVHR---------VGKTTFLVGETPKALQRKQFQEMAAHFN 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	PLN03142	46..967	CDD:215601	269/1095 (25%)
ercc6l2	NP_001362231.1	Tudor_ERCC6L2	11..66	CDD:410471	3/10 (30%)
		HepA	<78..651	CDD:440319	177/598 (30%)
		DEXHc_ERCC6L2	116..364	CDD:350763	72/256 (28%)
		VIGSSK	<1005..1030	CDD:464308	6/26 (23%)