DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iswi and smarca1

DIOPT Version :9

Sequence 1:	NP_523719.1	Gene:	Iswi / 36390	FlyBaseID:	FBgn0011604	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	XP_002931866.2	Gene:	smarca1 / 100101797	XenbaseID:	XB-GENE-492011	Length:	1034	Species:	Xenopus tropicalis

Alignment Length:	1042	Identity:	753/1042 - (72%)
Similarity:	873/1042 - (83%)	Gaps:	45/1042 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKTDTAAVEATEENSNETTSD------AATSSSGEKE--AEFDNKIEADRSRRFDFLLKQTEIFT 58
            |:...||.||.||...|....      ...:|..|||  .|::.|::.|||:||:|||||||:|.
Frog    19 SQEHLAATEAPEEEEEEKNDPPFLLKLPPKASRPEKEIDPEYEEKMKTDRSKRFEFLLKQTELFA 83

  Fly    59 HFMTNSA-KSPTKP----KGRPKKIKDKDKEK--DVADHRHRKTEQEEDEELLAEDSATKEI-FR 115
            ||:..:| ||||.|    .||| |||..:|:.  ...|:|||:||||||||||:|...|..: .|
Frog    84 HFIQPAAQKSPTSPLKVKLGRP-KIKKDEKQNLLSAGDYRHRRTEQEEDEELLSESRKTSNVCVR 147

  Fly   116 FDASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPH 180
            |:.||:|||.|.:||||:|||||||||||||||||||||||||||||||:|||||||::|..|||
Frog   148 FEESPSYIKGGTLRDYQVRGLNWMISLYENGINGILADEMGLGKTLQTIALLGYLKHYRNIPGPH 212

  Fly   181 IVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVF 245
            :|:||||||.||:||||:|.|||.|||||||::.|..|||||:||||||||||||||.|:|||||
Frog   213 MVLVPKSTLHNWMNEFKRWIPSLCAVCLIGDKNARAAFIRDVMMPGEWDVCVTSYEMVIKEKSVF 277

  Fly   246 KKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSS 310
            ||||||||||||||||||||||||||:|||||.||||:||||||||||||||||||||||||||:
Frog   278 KKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSA 342

  Fly   311 EDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKV 375
            ||||.||:||.||||..|:.|||||||||||||:||||||.|.||||:||::||.||||:||||:
Frog   343 EDFDSWFDTNNCLGDQKLVERLHAVLKPFLLRRIKAEVEKSLPPKKEVKIYLGLGKMQREWYTKI 407

  Fly   376 LLKDIDVVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLL 440
            |:||||::|.|||::||||.|||||||||.||||||||||||||||||||||||||||.:|||||
Frog   408 LMKDIDILNSAGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDTHLVYNSGKMVVLDKLL 472

  Fly   441 PKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFML 505
            ||.:||||||||||||||:||||||||.||.|.|||||||||||.|...|:.||..||:||:|||
Frog   473 PKFKEQGSRVLIFSQMTRVLDILEDYCMWRGYEYCRLDGQTPHEQREAAIETFNSPNSSKFIFML 537

  Fly   506 STRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAE 570
            ||||||||||||||||||:||||||||:|||||||||||||||.||||||||::||||:||||||
Frog   538 STRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQKKTVRVFRLITDNTVEERIVERAE 602

  Fly   571 VKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDVILERGEAKTAE 635
            :|||||.:|||.|||:|.:||:|.|||||.:||.||..||:||::::|||||..||||||.||||
Frog   603 IKLRLDSIVIQQGRLIDQQSNKLAKDEMLQMIRHGATHVFASKDSELTDEDITTILERGERKTAE 667

  Fly   636 QKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPKRERKANYAVDA 700
            ....|..:||||||.|::||.     :|:|.|||||:||||||:.: .|||||||||||||||||
Frog   668 MAERLQKMGESSLRNFSVDTE-----TSLYNFEGEDYREKQKLSMM-EWIEPPKRERKANYAVDA 726

  Fly   701 YFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKVPKNTELGSDAT 765
            |||:|||||||:.||||||||||.:||||||||||||||::||.|:|||:|||||::::| .:|:
Frog   727 YFRDALRVSEPRVPKAPRPPKQPNIQDFQFFPPRLFELLEKEILYYRKTIGYKVPRSSDL-PNAS 790

  Fly   766 KVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNIAKDVEGK 830
            ::|:||||||||||||..||.:|||.||:||||.|.|||||||||||||||||||||||::||||
Frog   791 QIQKEEQRKIDEAEPLCSEESEEKEKLLTQGFTNWNKRDFNQFIKANEKYGRDDIDNIAREVEGK 855

  Fly   831 TPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFHQLRLQYG 895
            |||||::|:.||||||.||||||:||.||||||.:||||:|||||||.|::||:|||||||:|||
Frog   856 TPEEVMDYSGVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAPFHQLRIQYG 920

  Fly   896 NNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQRRCNTLI 960
            .||||||||.|||||:|||||:||||||||||||..:|.:||||||||||||||:||||||||||
Frog   921 TNKGKNYTEEEDRFLICMLHKMGFDKENVYEELRQCVRNAPQFRFDWFIKSRTAMELQRRCNTLI 985

  Fly   961 TLIERENIELEEKERAEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQKRKSEVVATSSNSKKK 1025
            :|||:||:|:||||||||||:.||                  |||   .|||::||..||..|..
Frog   986 SLIEKENLEIEEKERAEKKKRQPK------------------PQP---SKRKADVVPDSSGKKDA 1029

  Fly  1026 KK 1027
            ||
Frog  1030 KK 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iswi	NP_523719.1	DBINO	<30..67	CDD:290603	21/39 (54%)
		SNF2_N	131..411	CDD:278600	230/279 (82%)
		DEXDc	148..287	CDD:238005	115/138 (83%)
		HELICc	422..553	CDD:238034	109/130 (84%)
		HAND	697..796	CDD:286232	71/98 (72%)
		SANT	797..838	CDD:197842	35/40 (88%)
		SANT	799..838	CDD:238096	33/38 (87%)
		SLIDE	853..965	CDD:286233	90/111 (81%)
smarca1	XP_002931866.2	PLN03142	64..1027	CDD:215601	736/991 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	477	1.000	Domainoid score	I429
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55711
Inparanoid	1	1.050	1517	1.000	Inparanoid score	I99
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144251at33208
OrthoFinder	1	1.000	-	-		FOG0001113
OrthoInspector	1	1.000	-	-		otm48320
Panther	1	1.100	-	-	LDO	PTHR10799
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1240
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.160