DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment muskelin and Mkln1

DIOPT Version :9

Sequence 1:	NP_610801.1	Gene:	muskelin / 36386	FlyBaseID:	FBgn0033757	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_112649.1	Gene:	Mkln1 / 83536	RGDID:	620076	Length:	735	Species:	Rattus norvegicus

Alignment Length:	813	Identity:	350/813 - (43%)
Similarity:	495/813 - (60%)	Gaps:	100/813 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LNFEIYRYSSYSPNYLPENVLVDCPNDQTSRWSAYTNSPPQFLTLKLRRPAIVKKIKFGKFEKSH 112
            |.:.::::||:|..|||||:|||.||||:||||:.:|.|||:|.|||.|||||:.|.|||:||:|
  Rat    16 LPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTH 80

  Fly   113 VCNIKKFRVYGGLDDEHMVLLLEGGLKNDNVPEVFNLRCLTEDGSENLPILYLKIVPLLSWGPSF 177
            |||:|||:|:||:::|:|..||..|||||...|.|.|:...::  :..|..::||||||||||||
  Rat    81 VCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDE--QMFPCRFIKIVPLLSWGPSF 143

  Fly   178 NFSIWYVELHGQDDPMYTSARMKNYNSLREVEIIKLCLKHFRQQGYLSAFGALQEQTNVQLEHPL 242
            |||||||||.|.|||......:..|:..||.|.|:||||||||..|..||.:||::|.:.||||:
  Rat   144 NFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPM 208

  Fly   243 ISELHKCLVLQGDFEKAERFIVECIDEGLMDEYLHKQDYKHSWHM---KHTE---SDIKPGNRGG 301
            ::::|..|||:|||:..|..|.:.:::||.::|:.:|:||..|..   |.|:   .|.:||.|||
  Rat   209 LTDMHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGG 273

  Fly   302 HQLVVDAKRRLIYLYGGWDGYQDLSDLWVFNIEDDQWTLLCERSELSNGPTPRSCHKMVFDPISE 366
            ||:|:|.:...:||:|||||.|||:|.|.::::::|||.:...:|..|||:.||||||..|....
  Rat   274 HQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRR 338

  Fly   367 NVFMLGRYLDNSIRTSDYIKSDFYLYDTRAGNWMQICDDTSQVGGPQLVYDHQMCMDTDKRTIYV 431
            .::.||||||:|:|.|..:|||||.||.....||.:.:||:..|||:||:|||||||::|..||.
  Rat   339 QIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYT 403

  Fly   432 FGGKILTPR-SVNATGAIEPEYSGLFSYHIATNTWAQILVDCHHASASLADVMSIKSRITHCMVF 495
            |||:|||.. ||:.:.|.||::||||:::....||..:..|..:|...     .|:|||.|||:|
  Rat   404 FGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPE-----DIQSRIGHCMLF 463

  Fly   496 HNKHRKLYIYGGQRGKEDLDEFLSYDVDTQAISVLNKEHPHHGTIAGNEAKFEPSSGYTLRATID 560
            |:|:|.||::||||.|..|::|.|||||:..:.:::     .||  ..::...|.:|:|.|||||
  Rat   464 HSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIIS-----DGT--KKDSGMVPMTGFTQRATID 521

  Fly   561 CERDEIYIFSSLSKVKDRRDIQHIDASNSFWVYSLRNHKWSRIYYCRHSGQDANSINNMNILGAS 625
            .|.:||::.|.|||.|::|:   .:..||||:|.:..:.||.:|     ..|..:..|:     |
  Rat   522 PELNEIHVLSGLSKDKEKRE---ENVRNSFWIYDIVRNSWSCVY-----KNDQAAKENL-----S 573

  Fly   626 KGDGTLEPCPRYAHQLVYDDVTNTHYLFGGNPGICQQQQLRLDDFWLLCLEKPKREEILKHCRFL 690
            |.....|||||:|||||||::...|||||||||.....::||||||.|.|.:|.::.:|:||::|
  Rat   574 KSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYL 638

  Fly   691 VRKLRYEEMTRQDPLKAMQYLRHHIADVIDHSDAEQLNNFHKLASLLFKNHDGNLDRECNTPALC 755
            :||.|:||..:.|||.|::||::.:...:||||.|:...|..|||.|||
  Rat   639 IRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFK---------------- 687

  Fly   756 ADADDLETDSDVSAKIKEELADGPATENLSLESNESMISSGISETASSPSSSSCTKRARTDCTPE 820
                                                   ||...||...|....|...||.
  Rat   688 ---------------------------------------SGSDFTALGFSDVDHTYAQRTQ---- 709

  Fly   821 LKNKRAFLFNKLVQLMPPSMVQPERNLSDFVVM 853
                   ||:.||...|.||..|:.||.|.:.:
  Rat   710 -------LFDTLVNFFPDSMTPPKGNLVDLITL 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
muskelin	NP_610801.1	Muskelin_N	44..241	CDD:284099	108/192 (56%)
		CTLH	240..292	CDD:128914	20/57 (35%)
		KELCH repeat	299..350	CDD:276965	23/50 (46%)
		Kelch_3	313..362	CDD:290151	25/48 (52%)
		KELCH repeat	354..412	CDD:276965	28/57 (49%)
Mkln1	NP_112649.1	Muskelin_N	12..207	CDD:284099	108/192 (56%)
		CTLH	206..258	CDD:128914	18/51 (35%)
		KELCH repeat	271..323	CDD:276965	24/51 (47%)
		Kelch_3	282..334	CDD:404319	25/51 (49%)
		Kelch 1	284..330		22/45 (49%)
		PLN02153	307..>475	CDD:177814	81/172 (47%)
		KELCH repeat	326..376	CDD:276965	25/49 (51%)
		Kelch 2	339..391		26/51 (51%)
		Kelch 3	400..458		24/62 (39%)
		KELCH repeat	456..512	CDD:276965	26/62 (42%)
		Kelch 4	469..515		18/52 (35%)
		Kelch 5	526..578		20/64 (31%)
		Kelch 6	597..651		27/53 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352065
Domainoid	1	1.000	233	1.000	Domainoid score	I2317
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8305
Inparanoid	1	1.050	678	1.000	Inparanoid score	I689
OMA	1	1.010	-	-		QHG51938
OrthoDB	1	1.010	-	-		D113887at33208
OrthoFinder	1	1.000	-	-		FOG0007364
OrthoInspector	1	1.000	-	-		oto97842
orthoMCL	1	0.900	-	-		OOG6_104896
Panther	1	1.100	-	-	LDO	PTHR15526
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5484
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910