DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment muskelin and MKLN1

DIOPT Version :9

Sequence 1:	NP_610801.1	Gene:	muskelin / 36386	FlyBaseID:	FBgn0033757	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_037387.2	Gene:	MKLN1 / 4289	HGNCID:	7109	Length:	735	Species:	Homo sapiens

Alignment Length:	813	Identity:	348/813 - (42%)
Similarity:	494/813 - (60%)	Gaps:	100/813 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LNFEIYRYSSYSPNYLPENVLVDCPNDQTSRWSAYTNSPPQFLTLKLRRPAIVKKIKFGKFEKSH 112
            |.:.::::||:|..|||||:|||.||||:||||:.:|.|||:|.|||.|||||:.|.|||:||:|
Human    16 LPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTH 80

  Fly   113 VCNIKKFRVYGGLDDEHMVLLLEGGLKNDNVPEVFNLRCLTEDGSENLPILYLKIVPLLSWGPSF 177
            |||:|||:|:||:::|:|..||..|||||...|.|.|:...::  :..|..::||||||||||||
Human    81 VCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDE--QMFPCRFIKIVPLLSWGPSF 143

  Fly   178 NFSIWYVELHGQDDPMYTSARMKNYNSLREVEIIKLCLKHFRQQGYLSAFGALQEQTNVQLEHPL 242
            |||||||||.|.|||......:..|:..||.|.|:||||||||..|..||.:||::|.:.||||:
Human   144 NFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPM 208

  Fly   243 ISELHKCLVLQGDFEKAERFIVECIDEGLMDEYLHKQDYKHSWHM---KHTE---SDIKPGNRGG 301
            ::::|..|||:|||:..|..|.:.:::||.::|:.:|:||..|..   |.|:   .|.:||.|||
Human   209 LTDIHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGG 273

  Fly   302 HQLVVDAKRRLIYLYGGWDGYQDLSDLWVFNIEDDQWTLLCERSELSNGPTPRSCHKMVFDPISE 366
            ||:|:|.:...:||:|||||.|||:|.|.::::::|||.:...:|..|||:.||||||..|....
Human   274 HQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRR 338

  Fly   367 NVFMLGRYLDNSIRTSDYIKSDFYLYDTRAGNWMQICDDTSQVGGPQLVYDHQMCMDTDKRTIYV 431
            .::.||||||:|:|.|..:|||||.||.....||.:.:||:..|||:||:|||||||::|..||.
Human   339 QIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYT 403

  Fly   432 FGGKILTPR-SVNATGAIEPEYSGLFSYHIATNTWAQILVDCHHASASLADVMSIKSRITHCMVF 495
            |||:|||.. ||:.:.|.||::||||:::....||..:..|..:|...     .|:|||.|||:|
Human   404 FGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPE-----DIQSRIGHCMLF 463

  Fly   496 HNKHRKLYIYGGQRGKEDLDEFLSYDVDTQAISVLNKEHPHHGTIAGNEAKFEPSSGYTLRATID 560
            |:|:|.||::||||.|..|::|.|||||:..:.:::     .||  ..::...|.:|:|.|||||
Human   464 HSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIIS-----DGT--KKDSGMVPMTGFTQRATID 521

  Fly   561 CERDEIYIFSSLSKVKDRRDIQHIDASNSFWVYSLRNHKWSRIYYCRHSGQDANSINNMNILGAS 625
            .|.:||::.|.|||.|::|:   .:..||||:|.:..:.||.:|....:.:|          ..:
Human   522 PELNEIHVLSGLSKDKEKRE---ENVRNSFWIYDIVRNSWSCVYKNDQAAKD----------NPT 573

  Fly   626 KGDGTLEPCPRYAHQLVYDDVTNTHYLFGGNPGICQQQQLRLDDFWLLCLEKPKREEILKHCRFL 690
            |.....|||||:|||||||::...|||||||||.....::||||||.|.|.:|.::.:|:||::|
Human   574 KSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYL 638

  Fly   691 VRKLRYEEMTRQDPLKAMQYLRHHIADVIDHSDAEQLNNFHKLASLLFKNHDGNLDRECNTPALC 755
            :||.|:||..:.|||.|::||::.:...:||||.|:...|..|||.|||
Human   639 IRKHRFEEKAQVDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFK---------------- 687

  Fly   756 ADADDLETDSDVSAKIKEELADGPATENLSLESNESMISSGISETASSPSSSSCTKRARTDCTPE 820
                                                   ||...||...|....|...||.
Human   688 ---------------------------------------SGSDFTALGFSDVDHTYAQRTQ---- 709

  Fly   821 LKNKRAFLFNKLVQLMPPSMVQPERNLSDFVVM 853
                   ||:.||...|.||..|:.||.|.:.:
Human   710 -------LFDTLVNFFPDSMTPPKGNLVDLITL 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
muskelin	NP_610801.1	Muskelin_N	44..241	CDD:284099	108/192 (56%)
		CTLH	240..292	CDD:128914	20/57 (35%)
		KELCH repeat	299..350	CDD:276965	23/50 (46%)
		Kelch_3	313..362	CDD:290151	25/48 (52%)
		KELCH repeat	354..412	CDD:276965	28/57 (49%)
MKLN1	NP_037387.2	Muskelin_N	12..207	CDD:284099	108/192 (56%)
		KELCH repeat	271..323	CDD:276965	24/51 (47%)
		Kelch_3	282..334	CDD:315978	25/51 (49%)
		Kelch 1	284..330		22/45 (49%)
		PLN02193	307..>475	CDD:330882	81/172 (47%)
		KELCH repeat	326..376	CDD:276965	25/49 (51%)
		Kelch 2	339..391		26/51 (51%)
		Kelch 3	408..458		19/54 (35%)
		KELCH repeat	456..512	CDD:276965	26/62 (42%)
		Kelch 4	469..515		18/52 (35%)
		Kelch 5	526..578		18/64 (28%)
		Kelch 6	597..651		27/53 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158084
Domainoid	1	1.000	233	1.000	Domainoid score	I2410
eggNOG	1	0.900	-	-		E1_KOG2437
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8305
Inparanoid	1	1.050	679	1.000	Inparanoid score	I718
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51938
OrthoDB	1	1.010	-	-		D113887at33208
OrthoFinder	1	1.000	-	-		FOG0007364
OrthoInspector	1	1.000	-	-		oto90739
orthoMCL	1	0.900	-	-		OOG6_104896
Panther	1	1.100	-	-	LDO	PTHR15526
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770