DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment muskelin and mkln1

DIOPT Version :9

Sequence 1:	NP_610801.1	Gene:	muskelin / 36386	FlyBaseID:	FBgn0033757	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_997859.1	Gene:	mkln1 / 325217	ZFINID:	ZDB-GENE-030131-3942	Length:	729	Species:	Danio rerio

Alignment Length:	816	Identity:	340/816 - (41%)
Similarity:	488/816 - (59%)	Gaps:	100/816 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SERLNFEIYRYSSYSPNYLPENVLVDCPNDQTSRWSAYTNSPPQFLTLKLRRPAIVKKIKFGKFE 109
            |..|::.:|::||||..|||||:|||.||||:||||:.:|.|||:|.|||.|||||..|.:||:|
Zfish     7 SRVLSYSVYKWSSYSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVLSITYGKYE 71

  Fly   110 KSHVCNIKKFRVYGGLDDEHMVLLLEGGLKNDNVPEVFNLRCLTEDGSENLPILYLKIVPLLSWG 174
            |:||||:|||:|:||:.:|:|..||..|||||...|.|.|:...::  :..|..::|||||:|||
Zfish    72 KTHVCNLKKFKVFGGMSEENMTELLSSGLKNDFNKETFTLKHKIDE--QMFPCRFIKIVPLMSWG 134

  Fly   175 PSFNFSIWYVELHGQDDPMYTSARMKNYNSLREVEIIKLCLKHFRQQGYLSAFGALQEQTNVQLE 239
            ||||||||::||||.:||......:..|:..||.|.|:||||||||..|..||.:||::|.:.||
Zfish   135 PSFNFSIWFIELHGIEDPEVVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTRIALE 199

  Fly   240 HPLISELHKCLVLQGDFEKAERFIVECIDEGLMDEYLHKQDYKHSWHM------KHTESDIKPGN 298
            ||:::.||:.|||:|||:..|..|.:.:.:||.::|:.:||||..|..      |....|.:||.
Zfish   200 HPMLTHLHERLVLRGDFDACEELIDKAVRDGLFNQYISQQDYKPRWSQIIPKCNKGDGDDNRPGM 264

  Fly   299 RGGHQLVVDAKRRLIYLYGGWDGYQDLSDLWVFNIEDDQWTLLCERSELSNGPTPRSCHKMVFDP 363
            |||||:|:|.:...:||:|||||.|||:|.|.::::::||..:...:|..:||:.||||||..|.
Zfish   265 RGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWACISRDTEKESGPSARSCHKMCIDS 329

  Fly   364 ISENVFMLGRYLDNSIRTSDYIKSDFYLYDTRAGNWMQICDDTSQVGGPQLVYDHQMCMDTDKRT 428
            ....::.||||||:|:|.|..:|||||.||..|..|..:.:|||..|||:||:|||||||::|..
Zfish   330 QRRQIYTLGRYLDSSVRNSKSLKSDFYCYDIDANTWTLLSEDTSADGGPKLVFDHQMCMDSEKHM 394

  Fly   429 IYVFGGKILTPR-SVNATGAIEPEYSGLFSYHIATNTWAQILVDCHHASASLADVMSIKSRITHC 492
            ||.|||:|||.. ||:.....||::|||::||....:|:.:..|..:|...     .|:|||.||
Zfish   395 IYTFGGRILTCNGSVDDGRTSEPQFSGLYAYHCQAGSWSLLREDSCNAGPE-----DIQSRIGHC 454

  Fly   493 MVFHNKHRKLYIYGGQRGKEDLDEFLSYDVDTQAISVLNKEHPHHGTIAGNEAKFEPSSGYTLRA 557
            |:||.::|.||::||||.|..|::|.|||||...:.:::     .||  ..::...|.:|:|.||
Zfish   455 MLFHTRNRCLYVFGGQRSKTYLNDFFSYDVDGDHVEIIS-----DGT--KKDSGMVPMTGFTQRA 512

  Fly   558 TIDCERDEIYIFSSLSKVKDRRDIQHIDASNSFWVYSLRNHKWSRIYYCRHSGQDANSINNMNIL 622
            |||.|.:||::.|.|||.||:|:   .:..||||:|.:..:.||    |.:....|...|....|
Zfish   513 TIDPELNEIHVLSGLSKDKDKRE---ENVRNSFWIYDIARNNWS----CVYKNDQAVKENPTKAL 570

  Fly   623 GASKGDGTLEPCPRYAHQLVYDDVTNTHYLFGGNPGICQQQQLRLDDFWLLCLEKPKREEILKHC 687
            ...      |||||:|||||||::...|||||||||.....::||||||.|.|.:|.:|.:|:||
Zfish   571 QEE------EPCPRFAHQLVYDELHKVHYLFGGNPGKSSSPKMRLDDFWSLKLCRPSKEYLLRHC 629

  Fly   688 RFLVRKLRYEEMTRQDPLKAMQYLRHHIADVIDHSDAEQLNNFHKLASLLFKNHDGNLDRECNTP 752
            ::|:||.|:||..:.:||.|::||::.::..:||:|.::...|..|.|.|||
Zfish   630 KYLIRKYRFEEKAQTEPLNALKYLQNDLSLTVDHTDPDETKEFQLLPSALFK------------- 681

  Fly   753 ALCADADDLETDSDVSAKIKEELADGPATENLSLESNESMISSGISETASSPSSSSCTKRARTDC 817
                                               |:...|..|.|:...:.:
Zfish   682 -----------------------------------SSSDFIPLGFSDVDQTYA------------ 699

  Fly   818 TPELKNKRAFLFNKLVQLMPPSMVQPERNLSDFVVM 853
                  :|..||:.||...|.:|..|:.||.|.:.:
Zfish   700 ------QRTQLFDTLVNFFPDNMTPPKGNLVDLITL 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
muskelin	NP_610801.1	Muskelin_N	44..241	CDD:284099	107/195 (55%)
		CTLH	240..292	CDD:128914	21/57 (37%)
		KELCH repeat	299..350	CDD:276965	22/50 (44%)
		Kelch_3	313..362	CDD:290151	23/48 (48%)
		KELCH repeat	354..412	CDD:276965	29/57 (51%)
mkln1	NP_997859.1	Muskelin_N	6..201	CDD:284099	107/195 (55%)
		KELCH repeat	265..316	CDD:276965	22/50 (44%)
		Kelch_3	276..328	CDD:290151	23/51 (45%)
		PLN02153	301..>495	CDD:177814	90/203 (44%)
		KELCH repeat	320..378	CDD:276965	29/57 (51%)
		KELCH repeat	381..435	CDD:276965	27/53 (51%)
		KELCH repeat	450..506	CDD:276965	25/62 (40%)
		Kelch_1	450..494	CDD:279660	22/48 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593955
Domainoid	1	1.000	236	1.000	Domainoid score	I2285
eggNOG	1	0.900	-	-		E1_KOG2437
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8305
Inparanoid	1	1.050	675	1.000	Inparanoid score	I701
OMA	1	1.010	-	-		QHG51938
OrthoDB	1	1.010	-	-		D113887at33208
OrthoFinder	1	1.000	-	-		FOG0007364
OrthoInspector	1	1.000	-	-		oto41100
orthoMCL	1	0.900	-	-		OOG6_104896
Panther	1	1.100	-	-	LDO	PTHR15526
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R699
SonicParanoid	1	1.000	-	-		X5484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840