Protein Alignment muskelin and Mkln1

DIOPT Version :10

• Sequence 1: NP_610801.1
• Gene: muskelin / 36386
• FlyBaseID: FBgn0033757
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_001416251.1
• Gene: Mkln1 / 27418
• MGIID: 1351638
• Length: 748
• Species: Mus musculus
• Alignment Length: 803
• Identity: 345/803 - (42%)
• Similarity: 486/803 - (60%)
• Gaps: 100/803 - (12%)

  Fly    58 YSPNYLPENVLVDCPNDQTSRWSAYTNSPPQFLTLKLRRPAIVKKIKFGKFEKSHVCNIKKFRVY 122
            |..|..|:|:|||.||||:||||:.:|.|||:|.|||.|||||:.|.|||:||:||||:|||:|:
Mouse    39 YLNNQKPKNILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVF 103

  Fly   123 GGLDDEHMVLLLEGGLKNDNVPEVFNLRCLTEDGSENLPILYLKIVPLLSWGPSFNFSIWYVELH 187
            ||:::|:|..||..|||||...|.|.|:...::  :..|..::|||||||||||||||||||||.
Mouse   104 GGMNEENMTELLSSGLKNDYNKETFTLKHKIDE--QMFPCRFIKIVPLLSWGPSFNFSIWYVELS 166

  Fly   188 GQDDPMYTSARMKNYNSLREVEIIKLCLKHFRQQGYLSAFGALQEQTNVQLEHPLISELHKCLVL 252
            |.|||......:..|:..||.|.|:||||||||..|..||.:||::|.:.||||:::::|..|||
Mouse   167 GIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDMHDKLVL 231

  Fly   253 QGDFEKAERFIVECIDEGLMDEYLHKQDYKHSWHM---KHTE---SDIKPGNRGGHQLVVDAKRR 311
            :|||:..|..|.:.:::||.::|:.:|:||..|..   |.|:   .|.:||.|||||:|:|.:..
Mouse   232 KGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTE 296

  Fly   312 LIYLYGGWDGYQDLSDLWVFNIEDDQWTLLCERSELSNGPTPRSCHKMVFDPISENVFMLGRYLD 376
            .:||:|||||.|||:|.|.::::::|||.:...:|..|||:.||||||..|.....::.||||||
Mouse   297 TVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLD 361

  Fly   377 NSIRTSDYIKSDFYLYDTRAGNWMQICDDTSQVGGPQLVYDHQMCMDTDKRTIYVFGGKILTPR- 440
            :|:|.|..:|||||.||.....||.:.:||:..|||:||:|||||||::|..||.|||:|||..
Mouse   362 SSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNG 426

  Fly   441 SVNATGAIEPEYSGLFSYHIATNTWAQILVDCHHASASLADVMSIKSRITHCMVFHNKHRKLYIY 505
            ||:.:.|.||::||||:::....||..:..|..:|...     .|:|||.|||:||:|:|.||::
Mouse   427 SVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPE-----DIQSRIGHCMLFHSKNRCLYVF 486

  Fly   506 GGQRGKEDLDEFLSYDVDTQAISVLNKEHPHHGTIAGNEAKFEPSSGYTLRATIDCERDEIYIFS 570
            ||||.|..|::|.|||||:..:.:::     .||  ..::...|.:|:|.|||||.|.:||::.|
Mouse   487 GGQRSKTYLNDFFSYDVDSDHVDIIS-----DGT--KKDSGMVPMTGFTQRATIDPELNEIHVLS 544

  Fly   571 SLSKVKDRRDIQHIDASNSFWVYSLRNHKWSRIYYCRHSGQDANSINNMNILGASKGDGTLEPCP 635
            .|||.|::|:   .:..||||:|.:..:.||.:|     ..|..:.:|:     ||.....||||
Mouse   545 GLSKDKEKRE---ENVRNSFWIYDIVRNSWSCVY-----KNDQATKDNL-----SKSLQEEEPCP 596

  Fly   636 RYAHQLVYDDVTNTHYLFGGNPGICQQQQLRLDDFWLLCLEKPKREEILKHCRFLVRKLRYEEMT 700
            |:|||||||::...|||||||||.....::||||||.|.|.:|.::.:|:||::|:||.|:||..
Mouse   597 RFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKA 661

  Fly   701 RQDPLKAMQYLRHHIADVIDHSDAEQLNNFHKLASLLFKNHDGNLDRECNTPALCADADDLETDS 765
            :.|||.|::||::.:...:||||.|:...|..|||.|||
Mouse   662 QMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFK-------------------------- 700

  Fly   766 DVSAKIKEELADGPATENLSLESNESMISSGISETASSPSSSSCTKRARTDCTPELKNKRAFLFN 830
                                         ||...||...|....|...||.           ||:
Mouse   701 -----------------------------SGSDFTALGFSDVDHTYAQRTQ-----------LFD 725

  Fly   831 KLVQLMPPSMVQPERNLSDFVVM 853
            .||...|.||..|:.||.|.:.:
Mouse   726 TLVNFFPDSMTPPKGNLVDLITL 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
muskelin	NP_610801.1	Muskelin_N	44..241	CDD:284099	103/182 (57%)
		CTLH	240..292	CDD:128914	20/57 (35%)
		KELCH repeat	299..350	CDD:276965	23/50 (46%)
		Kelch_3	310..362	CDD:433188	25/51 (49%)
		NanM	313..>517	CDD:442289	99/204 (49%)
		KELCH repeat	354..412	CDD:276965	28/57 (49%)
Mkln1	NP_001416251.1	None