DRSC/TRiP Functional Genomics Resources

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Protein Alignment muskelin and Mkln1

DIOPT Version :9

Sequence 1:NP_610801.1 Gene:muskelin / 36386 FlyBaseID:FBgn0033757 Length:853 Species:Drosophila melanogaster
Sequence 2:NP_038819.1 Gene:Mkln1 / 27418 MGIID:1351638 Length:735 Species:Mus musculus


Alignment Length:813 Identity:350/813 - (43%)
Similarity:496/813 - (61%) Gaps:100/813 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 LNFEIYRYSSYSPNYLPENVLVDCPNDQTSRWSAYTNSPPQFLTLKLRRPAIVKKIKFGKFEKSH 112
            |.:.::::||:|..|||||:|||.||||:||||:.:|.|||:|.|||.|||||:.|.|||:||:|
Mouse    16 LPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTH 80

  Fly   113 VCNIKKFRVYGGLDDEHMVLLLEGGLKNDNVPEVFNLRCLTEDGSENLPILYLKIVPLLSWGPSF 177
            |||:|||:|:||:::|:|..||..|||||...|.|.|:...::  :..|..::||||||||||||
Mouse    81 VCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDE--QMFPCRFIKIVPLLSWGPSF 143

  Fly   178 NFSIWYVELHGQDDPMYTSARMKNYNSLREVEIIKLCLKHFRQQGYLSAFGALQEQTNVQLEHPL 242
            |||||||||.|.|||......:..|:..||.|.|:||||||||..|..||.:||::|.:.||||:
Mouse   144 NFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPM 208

  Fly   243 ISELHKCLVLQGDFEKAERFIVECIDEGLMDEYLHKQDYKHSWHM---KHTE---SDIKPGNRGG 301
            ::::|..|||:|||:..|..|.:.:::||.::|:.:|:||..|..   |.|:   .|.:||.|||
Mouse   209 LTDMHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKS
TKGDGEDNRPGMRGG 273

  Fly   302 HQLVVDAKRRLIYLYGGWDGYQDLSDLWVFNIEDDQWTLLCERSELSNGPTPRSCHKMVFDPISE 366
            ||:|:|.:...:||:|||||.|||:|.|.::::::|||.:...:|..|||:.||||||..|....
Mouse   274 HQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRR 338

  Fly   367 NVFMLGRYLDNSIRTSDYIKSDFYLYDTRAGNWMQICDDTSQVGGPQLVYDHQMCMDTDKRTIYV 431
            .::.||||||:|:|.|..:|||||.||.....||.:.:||:..|||:||:|||||||::|..||.
Mouse   339 QIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYT 403

  Fly   432 FGGKILTPR-SVNATGAIEPEYSGLFSYHIATNTWAQILVDCHHASASLADVMSIKSRITHCMVF 495
            |||:|||.. ||:.:.|.||::||||:::....||..:..|..:|...     .|:|||.|||:|
Mouse   404 FGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPE-----DIQSRIGHCMLF 463

  Fly   496 HNKHRKLYIYGGQRGKEDLDEFLSYDVDTQAISVLNKEHPHHGTIAGNEAKFEPSSGYTLRATID 560
            |:|:|.||::||||.|..|::|.|||||:..:.:::     .||  ..::...|.:|:|.|||||
Mouse   464 HSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIIS-----DGT--KKDSGMVPMTGFTQRATID 521

  Fly   561 CERDEIYIFSSLSKVKDRRDIQHIDASNSFWVYSLRNHKWSRIYYCRHSGQDANSINNMNILGAS 625
            .|.:||::.|.|||.|::|:   .:..||||:|.:..:.||.:|     ..|..:.:|:     |
Mouse   522 PELNEIHVLSGLSKDKEKRE---ENVRNSFWIYDIVRNSWSCVY-----KNDQATKDNL-----S 573

  Fly   626 KGDGTLEPCPRYAHQLVYDDVTNTHYLFGGNPGICQQQQLRLDDFWLLCLEKPKREEILKHCRFL 690
            |.....|||||:|||||||::...|||||||||.....::||||||.|.|.:|.::.:|:||::|
Mouse   574 KSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYL 638

  Fly   691 VRKLRYEEMTRQDPLKAMQYLRHHIADVIDHSDAEQLNNFHKLASLLFKNHDGNLDRECNTPALC 755
            :||.|:||..:.|||.|::||::.:...:||||.|:...|..|||.|||                
Mouse   639 IRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFK---------------- 687

  Fly   756 ADADDLETDSDVSAKIKEELADGPATENLSLESNESMISSGISETASSPSSSSCTKRARTDCTPE 820
                                                   ||...||...|....|...||.    
Mouse   688 ---------------------------------------SGSDFTALGFSDVDHTYAQRTQ---- 709

  Fly   821 LKNKRAFLFNKLVQLMPPSMVQPERNLSDFVVM 853
                   ||:.||...|.||..|:.||.|.:.:
Mouse   710 -------LFDTLVNFFPDSMTPPKGNLVDLITL 735

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
muskelinNP_610801.1 Muskelin_N 44..241 CDD:284099 108/192 (56%)
CTLH 240..292 CDD:128914 20/57 (35%)
KELCH repeat 299..350 CDD:276965 23/50 (46%)
Kelch_3 313..362 CDD:290151 25/48 (52%)
KELCH repeat 354..412 CDD:276965 28/57 (49%)
Mkln1NP_038819.1 Muskelin_N 12..207 CDD:284099 108/192 (56%)
CTLH 206..258 CDD:128914 18/51 (35%)
KELCH repeat 271..323 CDD:276965 24/51 (47%)
Kelch_3 282..334 CDD:379174 25/51 (49%)
Kelch 1 284..330 22/45 (49%)
PLN02153 307..>475 CDD:177814 81/172 (47%)
KELCH repeat 326..376 CDD:276965 25/49 (51%)
Kelch 2 339..391 26/51 (51%)
Kelch 3 400..458 24/62 (39%)
KELCH repeat 456..512 CDD:276965 26/62 (42%)
Kelch 4 469..515 18/52 (35%)
Kelch 5 526..578 20/64 (31%)
Kelch 6 597..651 27/53 (51%)
Important for location in the cytosol. /evidence=ECO:0000269|PubMed:18710924 701..735 14/44 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848467
Domainoid 1 1.000 233 1.000 Domainoid score I2396
eggNOG 1 0.900 - - E1_KOG2437
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H8305
Inparanoid 1 1.050 679 1.000 Inparanoid score I716
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51938
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007364
OrthoInspector 1 1.000 - - oto94323
orthoMCL 1 0.900 - - OOG6_104896
Panther 1 1.100 - - LDO PTHR15526
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R699
SonicParanoid 1 1.000 - - X5484
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.790

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