DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment muskelin and mde6

DIOPT Version :9

Sequence 1:	NP_610801.1	Gene:	muskelin / 36386	FlyBaseID:	FBgn0033757	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_594297.2	Gene:	mde6 / 2542769	PomBaseID:	SPAC15A10.10	Length:	700	Species:	Schizosaccharomyces pombe

Alignment Length:	793	Identity:	226/793 - (28%)
Similarity:	343/793 - (43%)	Gaps:	146/793 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ERLNFEIYRYSSYSPNYLPENVLVDCPNDQTSRWSAYT------NSPPQFLTLKLRRPAIVKKIK 104
            :.|::.|..:||||..:.|.|:|:|.|:...||||..|      ||..|::.|||.:.|:|..|.
pombe     4 KELSYTIQSWSSYSGAFHPINILIDNPHQANSRWSCNTSICKPNNSEEQYVILKLDKLALVTDIT 68

  Fly   105 FGKFEKSHVCNIKKFRVYGGLDDEHMVLLLEGGLKNDNVPEVFNLRCLTEDGSEN-LPILYLKIV 168
            ||||...|:||:|.|.||||.:...|..||..||.||:..|.|.|.....:..|| :...|:|||
pombe    69 FGKFHTPHLCNLKDFIVYGGREQHLMFPLLRAGLTNDSNRETFPLCIKKYNKIENSIACKYIKIV 133

  Fly   169 PLLSWGPSFNFSIWYVELHGQDDPMYTSARMKNYNSLREVEIIKLCLKHFRQQGYLSAFGALQEQ 233
            ||.:....||.|||||.|||.|.....|...||.....|.:.:...|.:|..:|.|.....:.:.
pombe   134 PLQAHAHEFNMSIWYVALHGIDSASALSCTEKNRALHLEKKALNCLLSYFAFKGKLDICSVILQS 198

  Fly   234 TNVQLEHPLISELHKCLVLQGDFEKAERFIVECIDEGLMDEYLHKQDYKHSWHMKHTESDIKP-- 296
            ..:.:.|..:..::......||.:|.    :....:.|..|.:.|      | .||..:.::.
pombe   199 YQLSIPHSPLMRMYDAFCRLGDTQKT----ILLFQQELQAEIIEK------W-PKHKLTKLRSHR 252

  Fly   297 --------GNRGGHQLVVDAKRRLIYLYGGWDGYQDLSDLWVFNIEDDQWTLLCERSELSNG-PT 352
                    ..|.|||:|.:.|...|||||||||.:..||.|::|::.|.|.:     |...| |.
pombe   253 IATFLKGISRRSGHQMVYNPKDNCIYLYGGWDGVKTFSDFWIYNVDKDLWIM-----ENEYGIPG 312

  Fly   353 PRSCHKMVFDPISENVFMLGRYLDNSIRTS--DYIKSDFYLYDTRAGNWMQICDDTSQVGGPQLV 415
            .|.||:||.|...:.:::||.|..:|..|.  ...::||:.:|.....|..:..|||:.|||..:
pombe   313 ERVCHRMVIDTSQQKLYLLGNYFGSSRETEVPPDARTDFWEFDISKKVWTCLSYDTSKDGGPAAI 377

  Fly   416 YDHQMCMDTDKRTIYVFGGKILTPRSVNATGAIEPEYSGLFSYHIATNTWAQILVDCH----HAS 476
            :||.|.:|..:..:||.||....|.        |..:.||::|......|.|:.|...    |..
pombe   378 FDHGMSVDEKRGIVYVSGGCKWDPD--------ELVFEGLYAYDTKNRIWEQLAVRYEDRQKHCE 434

  Fly   477 ASLADVMSIKSRITHCMVFHNKHRKLYIYGGQRGKEDLDEFLSYD----VDTQAISVLNKEHPHH 537
            ..:       .|:.|||.:.....||||:|||          |||    :|...|.:..:|...|
pombe   435 FKI-------ERMGHCMEYFPDENKLYIFGGQ----------SYDQEFILDMCYIKLETREAVQH 482

  Fly   538 GTIAGNEAKFEPSSGYTLRATIDCERDEIYIFSSLSKVKDRRDIQHIDASNSFWVYSLRNHKWSR 602
              :..|:....||..:..|:.:|.:...|:.....    ::|:| |.....|.|::.:...:|.:
pombe   483 --VRKNDTSQSPSPSFCQRSIMDSKNHRIFTMFGF----EQRNI-HKVLRPSLWIFYITTEEWVK 540

  Fly   603 IYYCRHSGQDANSINNMNILGASKGDGTLEPCPRYAHQLVYDDVTNTHYLFGGNPGICQQQQLRL 667
            |          :.||        :.:|...||.|:.|.:..|...|..||.|||......:.::|
pombe   541 I----------SDIN--------EEEGNEHPCSRFGHAVAADLNRNIIYLMGGNASTHPLRPMKL 587

  Fly   668 DDFWLLCLEKPKREEIL-----KHC----RFLVRKLRYEEMTRQDPLKAMQYLRHHIADVIDHSD 723
            .|||.|        :||     |||    ...:...|:.|:..::..||::||:..:....|.|.
pombe   588 SDFWKL--------DILDRWGIKHCLSNVSLQLHLHRFHELVSENLAKAVEYLQKSMQPQFDKSP 644

  Fly   724 AEQLNNFHKLASLLFKNHDGNLDRECNTPALCADA-DDLETDSDVSAKIKE------ELADGPAT 781
                         ||.|            ||..|| .....:.|::.:..|      :|.  |..
pombe   645 -------------LFWN------------ALILDAFSGTHKNKDIAQRRFETFQTIYDLL--PVD 682

  Fly   782 ENLSLESNESMIS 794
            || ::..|||:::
pombe   683 EN-TVAPNESLLN 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
muskelin	NP_610801.1	Muskelin_N	44..241	CDD:284099	75/201 (37%)
		CTLH	240..292	CDD:128914	10/51 (20%)
		KELCH repeat	299..350	CDD:276965	22/50 (44%)
		Kelch_3	313..362	CDD:290151	23/49 (47%)
		KELCH repeat	354..412	CDD:276965	19/59 (32%)
mde6	NP_594297.2	Muskelin_N	2..206	CDD:284099	75/201 (37%)
		Kelch_1	262..302	CDD:279660	20/39 (51%)
		KELCH repeat	263..308	CDD:276965	22/49 (45%)
		KELCH repeat	314..374	CDD:276965	19/59 (32%)
		Kelch_2	314..367	CDD:284956	15/52 (29%)
		KELCH repeat	377..423	CDD:276965	15/53 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	126	1.000	Domainoid score	I1382
eggNOG	1	0.900	-	-		E1_KOG2437
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8305
Inparanoid	1	1.050	289	1.000	Inparanoid score	I639
OMA	1	1.010	-	-		QHG51938
OrthoFinder	1	1.000	-	-		FOG0007364
OrthoInspector	1	1.000	-	-		oto101652
orthoMCL	1	0.900	-	-		OOG6_104896
Panther	1	1.100	-	-	LDO	PTHR15526
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R699
SonicParanoid	1	1.000	-	-		X5484
TreeFam	1	0.960	-	-
	14	13.860