DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17760 and GNA14

DIOPT Version :9

Sequence 1:	NP_001036539.1	Gene:	CG17760 / 36385	FlyBaseID:	FBgn0033756	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_004288.1	Gene:	GNA14 / 9630	HGNCID:	4382	Length:	355	Species:	Homo sapiens

Alignment Length:	351	Identity:	211/351 - (60%)
Similarity:	276/351 - (78%)	Gaps:	0/351 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CCLSDQACEERRISREIDKFLKAEKKKARRELKLLVLGTGESGKTTFIKQMRIIHGKGFLDKERK 67
            ||||.:..|.:|||.||::.|:.:||.||||||||:||||||||:|||||||||||.|:.|::||
Human     5 CCLSAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDRK 69

  Fly    68 QFTKNVFQNIFMAIQSMISAMDTLRIPYGQQEHSKLADLVKSIDYKTVTRLEAPYLNAIKTLWKD 132
            .|||.|:||||.|:|:||.|||||||.|..:::.:.|.:::.::...|:.|....:.|||.||:|
Human    70 GFTKLVYQNIFTAMQAMIRAMDTLRIQYVCEQNKENAQIIREVEVDKVSMLSREQVEAIKQLWQD 134

  Fly   133 AGIKECYNRRREYQLTDSTEYFLNDIARIERSDYQATDQDILHVRAPTTNIVEYPFNLDGFLIRL 197
            .||:|||:|||||||:||.:|:|.||.||....:..|.||:|.||.|||.|:||||:|:..:.|:
Human   135 PGIQECYDRRREYQLSDSAKYYLTDIDRIATPSFVPTQQDVLRVRVPTTGIIEYPFDLENIIFRM 199

  Fly   198 VDVAGQRTERRKWIHCFSNVTSIMFLVAMSEFDLSLAESENDNRMKESKALFHNIISFSWFQHSS 262
            |||.|||:|||||||||.:||||:||||:||:|..|||.:|:|||:||||||..||::.||.:||
Human   200 VDVGGQRSERRKWIHCFESVTSIIFLVALSEYDQVLAECDNENRMEESKALFKTIITYPWFLNSS 264

  Fly   263 VILFLNKEDLFKKKILSTHLADYFPEYNGPKKDAKAAREFILYMFTSVNPDPYKCIYPHFTVATN 327
            |||||||:||.::||:.:||..|||||.|||:|.:|||:|||.::...|||..|.||.|||.||:
Human   265 VILFLNKKDLLEEKIMYSHLISYFPEYTGPKQDVRAARDFILKLYQDQNPDKEKVIYSHFTCATD 329

  Fly   328 TENIKFVFTAVKDTILELHLSETNLL 353
            |:||:|||.|||||||:|:|.|.||:
Human   330 TDNIRFVFAAVKDTILQLNLREFNLV 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17760	NP_001036539.1	G_alpha	13..351	CDD:214595	204/337 (61%)
CG17760	NP_001036539.1	G-alpha	34..347	CDD:206639	190/312 (61%)
GNA14	NP_004288.1	G_alpha	16..353	CDD:214595	204/336 (61%)
		G-alpha	36..349	CDD:206639	190/312 (61%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	37..50		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		5/8 (63%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	325..330		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151724
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D373878at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760